CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1571
Family Name Alpha-1A adrenergic receptor Ligand RWJ-68141 Family
No. of Seeds 5 No. of Other Members 4
Family Centroid CFAMM00243410 Functional Category Investigative Drug with Natural Product
Superfamily Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor Binder Superfamily 2
Class Class 2070

Cousin Family NamesSeedsMembers
D(2) dopamine receptor Ligand Pardoprunox Family 4 81
Tumor necrosis factor Inhibitor Tgaac-94 Family 6 107
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Muscarinic acetylcholine receptor M1 Ligand AC-260584 Family 4 36
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
C-C chemokine receptor type 1 Ligand BX-471 Family 10 67
Glucose-6-phosphate 1-dehydrogenase Inhibitor Metazamide Family 9 69
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 18 12
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 6 23
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Alpha-1A adrenergic receptor Ligand Naftopidil Family 15 119
Alpha-1A adrenergic receptor Ligand Ro-11-04253 Family 1 1
Macrophage migration inhibitory factor Inhibitor 3-benzyl-5-me... 10 42
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-(3-morpholinop... 24 102
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 8 41
Leukotriene A-4 hydrolase Inhibitor 1-[4-(4-iodophenoxy)phenyl... 5 18
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 9
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 28 24
Liver carboxylesterase 1 Inhibitor SCH-48375 Family 2 28
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 2 17
D(2) dopamine receptor ligand 7-[4-[4-(2-ethoxyphenyl)piperazi... 12 14
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 14 12
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 9 22
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 15 14
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 6 2
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 2 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 12 10
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-N... 2 2
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 4 8
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 1
Survival motor neuron protein and DNA-(apurinic or apyrimidini... 1 5
Capsid scaffolding protein inhibitor AC1LAC6N family 2 1
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 3
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 5 0
Survival motor neuron protein and ATP-dependent DNA helicase Q... 1 4
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 4 1
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 1 0
Dipeptidyl peptidase 4 inhibitor (2S)-1-[(2S,4S)-4-(4-methoxya... 1 26
Renin inhibitor 5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4... 5 9
D(2) dopamine receptor and Muscarinic acetylcholine receptor M... 1 0
Translocator protein inhibitor N-methyl-2-[2-oxo-5-[4-(trifluo... 9 3
Translocator protein inhibitor 2-(5-bromo-2-oxo-1,3-benzoxazol... 1 0
Translocator protein inhibitor 2-(5-chloro-2-oxo-1,3-benzoxazo... 1 2
Translocator protein inhibitor N-methyl-2-[5-(N-methylanilino)... 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 2 0
Glutamate receptor ionotropic, NMDA 2B and Potassium voltage-g... 2 1
Kinesin-like protein KIF11 and Potassium voltage-gated channel... 10 2
5-hydroxytryptamine receptor 1A ligand SureCN10513645 family 9 1
Mu-type opioid receptor ligand AGN-PC-00NCMO family 3 1
5-hydroxytryptamine receptor 1A ligand AGN-PC-00FVK4 family 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 9
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 12
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 1 0
Peptide deformylase inhibitor (2S)-N-(cyclopropylmethyl)-N-[2-... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00243410 DNC004925 Investigative Drug RWJ-68141

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

22854 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543