CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1574
Family Name Alpha-1A adrenergic receptor Ligand SNAP-6201 Family
No. of Seeds 41 No. of Other Members 94
Family Centroid CFAMM00243507 Functional Category Investigative Drug with Natural Product
Superfamily Integrin alpha-4 Inhibitor R1295 Superfamily
Class Class 820

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Anileridine Family 3 18
Integrin alpha-4 Inhibitor R1295 Family 18 59
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 19 32
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Phospholipase D1 Inhibitor Halopemide Family 17 111
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 11 20
C-C chemokine receptor type 5 ligand 1-[1-[[(3S,4R)-1-(cyclope... 7 13
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 5 7
Sodium-dependent serotonin transporter and Sodium-dependent do... 2 1
Neutrophil elastase inhibitor SureCN7423499 family 5 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 13 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 2
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 4 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 4 0
Cellular tumor antigen p53 and Retinal dehydrogenase 1 inhibit... 1 4
Dipeptidyl peptidase 4 inhibitor SureCN389715 family 2 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 10 0
Gonadotropin-releasing hormone receptor ligand 3-[(2R)-2-amino... 9 21
Gonadotropin-releasing hormone receptor ligand 3-[(2R)-2-amino... 3 1
Gonadotropin-releasing hormone receptor and Cytochrome P450 3A... 7 8
Dipeptidyl peptidase 4 inhibitor 2-[[4-[(3R)-3-aminopiperidin-... 1 3
Glucocorticoid receptor ligand 5-[(3-methylphenyl)methyl]-6-(4... 4 5
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 5 7
Alpha-1A adrenergic receptor and Histamine H1 receptor ligand ... 13 1
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 20 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
Microtubule-associated protein tau and Cytochrome P450 3A4 inh... 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00243547 CHEMBL143066 Bioactive methyl 4-(3-chlorophenyl)-3-[3-(4-methoxycarbonyl-4-phenylpiperidin-1-yl)propylcarbamoyl]-6-methyl-2-oxo-1,4-dihydropyrimidine-5-carboxylate
CFAMM00243525 CHEMBL358590 Bioactive AGN-PC-075PQ7
CFAMM00243554 CHEMBL341838 Bioactive methyl 4-(3,4-difluorophenyl)-3-[4-(4-methoxycarbonyl-4-phenylpiperidin-1-yl)piperidine-1-carbonyl]-6-(methoxymethyl)-2-oxo-1,4-dihydropyrimidine-5-carboxylate
CFAMM00243504 CHEMBL90453 Bioactive (4R)-3-acetyl-4-(3,4-difluorophenyl)-N-[3-[4-(4-fluorophenyl)piperidin-1-yl]propyl]-1,6-dimethyl-2-oxo-4H-pyrimidine-5-carboxamide
CFAMM00243510 CHEMBL145894 Bioactive methyl 4-(3,4-difluorophenyl)-6-methyl-3-[3-[4-(2-methylphenyl)-4-(4-methylphenyl)piperidin-1-yl]propylcarbamoyl]-2-oxo-1,4-dihydropyrimidine-5-carboxylate
CFAMM00243474 CHEMBL359173 Bioactive methyl 3-[3-(4-methoxycarbonyl-4-phenylpiperidin-1-yl)propylcarbamoyl]-6-methyl-4-(4-methylphenyl)-2-oxo-1,4-dihydropyrimidine-5-carboxylate
CFAMM00243553 CHEMBL93623 Bioactive methyl (4R)-4-(3,4-difluorophenyl)-5-[3-[4-(4-fluorophenyl)piperidin-1-yl]propylcarbamoyl]-1,6-dimethyl-2-oxo-4H-pyrimidine-3-carboxylate
CFAMM00243562 CHEMBL144925 Bioactive methyl 1-[3-[[5-carbamoyl-4-(2,4-difluorophenyl)-6-ethyl-2-oxo-1,4-dihydropyrimidine-3-carbonyl]amino]propyl]-4-phenylpiperidine-4-carboxylate
CFAMM00243473 CHEMBL358489 Bioactive methyl 3-[3-(4-methoxycarbonyl-4-phenylpiperidin-1-yl)propylcarbamoyl]-6-methyl-4-(3-methylphenyl)-2-oxo-1,4-dihydropyrimidine-5-carboxylate
CFAMM00243543 CHEMBL142981 Bioactive methyl 4-(3,4-difluorophenyl)-3-[5-(4-methoxycarbonyl-4-phenylpiperidin-1-yl)pentyl]-6-methyl-2-oxo-1,4-dihydropyrimidine-5-carboxylate
CFAMM00243493 CHEMBL35520 Bioactive AGN-PC-073RDO
CFAMM00243508 CHEMBL146163 Bioactive methyl 4-(4-chlorophenyl)-3-[3-(4-methoxycarbonyl-4-phenylpiperidin-1-yl)propylcarbamoyl]-6-methyl-2-oxo-1,4-dihydropyrimidine-5-carboxylate
CFAMM00243549 CHEMBL144938 Bioactive methyl 4-(3,4-difluorophenyl)-3-[2-[2-(4-methoxycarbonyl-4-phenylpiperidin-1-yl)ethylamino]-2-oxoethyl]-6-methyl-2-oxo-1,4-dihydropyrimidine-5-carboxylate
CFAMM00243450 CHEMBL145553 Bioactive methyl 3-[4-(4-methoxycarbonyl-4-phenylpiperidin-1-yl)piperidine-1-carbonyl]-6-(methoxymethyl)-2-oxo-4-(3,4,5-trifluorophenyl)-1,4-dihydropyrimidine-5-carboxylate
CFAMM00243520 CHEMBL145353 Bioactive methyl 1-[5-[5-carbamoyl-4-(2,4-difluorophenyl)-2,6-dimethyl-4H-pyrimidin-3-yl]pentyl]-4-phenylpiperidine-4-carboxylate
CFAMM00243548 CHEMBL357628 Bioactive 3-N-[3-(4-cyano-4-phenylpiperidin-1-yl)propyl]-4-(2,4-difluorophenyl)-6-ethyl-2-oxo-1,4-dihydropyrimidine-3,5-dicarboxamide
CFAMM00243507 DNC004930 Investigative Drug SNAP-6201

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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