CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1575
Family Name Alpha-1A adrenergic receptor Ligand L-771688 Family
No. of Seeds 8 No. of Other Members 14
Family Centroid CFAMM00243582 Functional Category Investigative Drug with Natural Product
Superfamily Alpha-1A adrenergic receptor Ligand L-771688 Superfamily
Class Class 240

Cousin Family NamesSeedsMembers
Reverse transcriptase Inhibitor Nevirapine Family 23 640
D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... 22 170
Muscarinic acetylcholine receptor M4 Ligand Tropicamide Family 3 73
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapone Family 9 243
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Histamine H1 receptor Ligand Triprolidine Family 19 316
SUR2-type K(ATP) channel Ligand Nicorandil Family 5 85
Prothrombin Inhibitor Ximelegatran Family 8 157
Neuromedin-K receptor Ligand SB222200 Family 17 235
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Glutamate receptor AMPA subtype Ligand CX-516 Family 9 24
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Substance-P receptor Ligand TAK-637 Family 18 63
Amg 423 family 7 47
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 93
Transient receptor potential cation channel subfamily V member... 6 23
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... 5 12
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
C-C chemokine receptor type 5 Ligand GT-1282 Family 21 14
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
Poly [ADP-ribose] polymerase 1 Inhibitor 3-ethenylquinoline-8-... 8 4
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Hydroxycarboxylic acid receptor 2 Ligand 2-(6-phenylhexyl)pyri... 4 11
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 4 12
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 1 13
Neutrophil elastase inhibitor 2-[2-oxo-6-phenyl-3-(2-pyridin-2... 1 2
Neutrophil elastase inhibitor SureCN7284457 family 4 6
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 7 58
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 17 28
Muscarinic acetylcholine receptor M2 ligand AGN-PC-0745NK family 2 6
Voltage-dependent T-type calcium channel subunit alpha-1H liga... 1 8
Survival motor neuron protein and Beta-lactamase inhibitor CHE... 1 0
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1233942 ... 6 0
Neuronal acetylcholine receptor subunit alpha-7 and Acetylchol... 2 3
Platelet-activating factor receptor ligand YM-461 family 1 11
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04SK7R family 3 3
Substance-K receptor ligand N-[1-[[(2R)-5-[4-(oxan-4-ylmethyl)... 2 0
Substance-P receptor and Neuromedin-K receptor ligand SureCN88... 4 14
Histamine H3 receptor ligand SureCN1857507 family 1 4
Renin inhibitor (3R,4S)-N-cyclopropyl-N-[[2-(3-methoxypropyl)q... 2 0
Renin and Potassium voltage-gated channel subfamily H member 2... 9 2
Renin inhibitor [2-[(3-fluoro-2-methylphenyl)methyl]-6-methyl-... 2 1
Neuronal acetylcholine receptor subunit alpha-7 and Neuronal a... 8 5
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 4
Cell division cycle 7-related protein kinase and Protein DBF4 ... 1 5
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 1 1
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
Oxytocin receptor ligand (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)... 20 2
Melanin-concentrating hormone receptor 1 ligand N-[(3S)-1-[[(3... 2 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Di... 2 3
Probable G-protein coupled receptor 142 ligand (2S)-N-(2-oxo-5... 2 1
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 6 8
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
Neutrophil elastase inhibitor N-[(2S)-3-methyl-1-oxo-1-[(2S)-2... 4 4
Gonadotropin-releasing hormone receptor ligand 1-[(2,6-difluor... 2 17
Gonadotropin-releasing hormone receptor ligand 6-[(4-chloro-2-... 3 3
Motilin receptor ligand SureCN2768052 family 3 0
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 1
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 7 7
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Histone deacetylase 1 inhibitor (2S)-N'-hydroxy-2-(pyridine-2-... 3 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 2 2
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 1 2
Renin inhibitor tert-butyl N-[1-[[1-[[1-cyclohexyl-4,4-difluor... 5 0
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 4 1
Prothrombin inhibitor AGN-PC-073GVF family 12 1
Platelet-activating factor receptor ligand (4R)-N-(3-benzoylph... 2 1
Platelet-activating factor receptor ligand SureCN9853140 family 3 3
Gonadotropin-releasing hormone receptor ligand 1-[2-(3,5-dimet... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 5 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 7 2
Transient receptor potential cation channel subfamily V member... 1 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 4
Melanin-concentrating hormone receptor 1 ligand SureCN4917950 ... 3 5
Glucocorticoid receptor ligand 5-[(6-methylpyridin-2-yl)methyl... 3 0
Acetylcholinesterase inhibitor CHEMBL267591 family 5 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00243588 CHEMBL327327 Bioactive (4R)-4-(3,4-difluorophenyl)-6-methyl-2-oxo-N-[3-(4-pyridin-2-ylpiperidin-1-yl)propyl]-3,4-dihydro-1H-pyrimidine-5-carboxamide
CFAMM00243587 CHEMBL429697 Bioactive methyl (4S)-4-(3,4-difluorophenyl)-6-(methoxymethyl)-2-oxo-3-[[(1R,3R)-3-(4-pyridin-2-ylpiperidin-1-yl)cyclopentyl]carbamoyl]-1,4-dihydropyrimidine-5-carboxylate
CFAMM00243576 CHEMBL57691 Bioactive methyl (4S)-4-(3,4-difluorophenyl)-6-(methoxymethyl)-2-oxo-3-[[(1S,3R)-3-(4-pyridin-2-ylpiperidin-1-yl)cyclopentyl]carbamoyl]-1,4-dihydropyrimidine-5-carboxylate
CFAMM00243592 CHEMBL56248 Bioactive methyl (4S)-4-(3,4-difluorophenyl)-6-(methoxymethyl)-2-oxo-3-[[(1S,3S)-3-(4-pyridin-2-ylpiperidin-1-yl)cyclopentyl]carbamoyl]-1,4-dihydropyrimidine-5-carboxylate
CFAMM00243591 CHEMBL265001 Bioactive SureCN14511564
CFAMM00243574 CHEMBL293515 Bioactive methyl (4S)-4-(3,4-difluorophenyl)-6-(methoxymethyl)-2-oxo-3-[[(1R,3S)-3-(4-pyridin-2-ylpiperidin-1-yl)cyclopentyl]carbamoyl]-1,4-dihydropyrimidine-5-carboxylate
CFAMM00243590 CHEMBL91125 Bioactive (4R)-4-(3,4-difluorophenyl)-6-(methoxymethyl)-2-oxo-N-[3-(4-pyridin-2-ylpiperidin-1-yl)propyl]-3,4-dihydro-1H-pyrimidine-5-carboxamide
CFAMM00243582 DNC004931 Investigative Drug L-771688

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

48709 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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