CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1577
Family Name Alpha-1A adrenergic receptor Ligand Upidosin Family
No. of Seeds 8 No. of Other Members 46
Family Centroid CFAMM00243661 Functional Category Investigative Drug with Natural Product
Superfamily Alpha-1A adrenergic receptor Ligand Upidosin Superfamily
Class Class 1677

Cousin Family NamesSeedsMembers
Beta-1 adrenergic receptor Ligand Acebutolol Family 2 27
Sodium channel protein type 5 subunit alpha Ligand Proparacain... 2 26
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 3 27
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 3 67
D(2) dopamine receptor Ligand Pardoprunox Family 4 81
D(4) dopamine receptor Ligand PD-165167 Family 2 96
Tumor necrosis factor Inhibitor Tgaac-94 Family 6 107
Cinitapride family 4 22
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Muscarinic acetylcholine receptor M1 Ligand AC-260584 Family 4 36
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
Neuropeptide Y receptor type 1 Ligand BMS-193885 Family 3 11
C-C chemokine receptor type 1 Ligand BX-471 Family 10 67
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Alpha-1 adrenergic receptor Ligand DC-015 Family 8 25
5-hydroxytryptamine receptor 1A Ligand Du 125530 Family 2 0
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
Amine oxidase [flavin-containing] A Inhibitor Ethyl 4-(2-oxo-2... 4 117
Tubulin Inhibitor WR85915 Family 3 15
Sodium channel protein type 10 subunit alpha Ligand A-803467 F... 2 81
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 7 5
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 18 12
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Cruzipain Inhibitor 1-(3-methoxy-benzyl)-5-methyl-1h-indole-2,... 2 11
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 4-(2... 4 31
Oxytocin receptor and Vasopressin V1a receptor Ligand L-371257... 8 92
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 6 23
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand RWJ-68141 Family 5 4
Alpha-1A adrenergic receptor Ligand Naftopidil Family 15 119
Alpha-1A adrenergic receptor Ligand Ro-11-04253 Family 1 1
Peroxisome proliferator-activated receptor gamma and Peroxisom... 1 31
Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family 4 23
Oxysterols receptor LXR-alpha Ligand N-{4-[2-(4-methoxyphenyl)... 3 16
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Liver carboxylesterase 1 Inhibitor 5-(trifluoromethoxy)-1h-ind... 3 12
Amyloid beta A4 protein Inhibitor 6-iodo-4'-methylaminoflavone... 3 33
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Alpha-1A adrenergic receptor and D(2) dopamine receptor Ligand... 5 49
Histone deacetylase 2 Inhibitor N-(4-amino-3'-methoxybiphenyl-... 3 49
Leukotriene A-4 hydrolase Inhibitor N5-[4-(2-oxo-3-phenylpropo... 1 61
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Macrophage migration inhibitory factor Inhibitor 3-benzyl-5-me... 10 42
Macrophage migration inhibitory factor Inhibitor Benzofuran-2-... 5 67
Sodium channel protein type 10 subunit alpha and Sodium channe... 2 13
Amine oxidase [flavin-containing] B Inhibitor N-methyl-n-pheny... 6 25
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-(3-morpholinop... 24 102
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 8 41
Leukotriene A-4 hydrolase Inhibitor 1-[4-(4-iodophenoxy)phenyl... 5 18
Urotensin-2 receptor Ligand JNJ-28318706 Family 4 227
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 28
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 28 24
D(2) dopamine receptor Ligand Epidepride Family 31 66
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 8 39
Metabotropic glutamate receptor 5 Ligand N-(3-(3-cyanobenzamid... 2 13
Liver carboxylesterase 1 Inhibitor SCH-48375 Family 2 28
Tubulin beta chain Inhibitor Gnf-pf-117 Family 2 16
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 1 7
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 2 17
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
3-oxo-5-alpha-steroid 4-dehydrogenase 2 and 3-oxo-5-alpha-ster... 3 5
Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]... 11 10
D(2) dopamine receptor ligand 7-[4-[4-(2-ethoxyphenyl)piperazi... 12 14
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEH3 family 3 16
Stromelysin-1 and 72 kDa type IV collagenase inhibitor [(2S)-2... 2 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 14 12
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 5 13
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[(3... 2 11
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 9 22
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide, 8... 4 15
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 15 14
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 3 6
Cannabinoid receptor 2 ligand AGN-PC-080VZH family 3 33
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 3 2
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 2 0
C-C chemokine receptor type 3 ligand SureCN6705515 family 2 16
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 11 4
Alpha-1A adrenergic receptor and 5-hydroxytryptamine receptor ... 3 0
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-3... 2 3
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 49 8
Kappa-type opioid receptor ligand AGN-PC-09M90I family 2 3
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 4
D(3) dopamine receptor and D(1A) dopamine receptor ligand N-[(... 6 14
Microsomal triglyceride transfer protein large subunit inhibit... 4 5
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-N... 2 2
Coagulation factor X and Trypsin-1 inhibitor AGN-PC-01ZLS4 family 2 8
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 1
Multidrug resistance protein 1 inhibitor 1-[2-[(2R)-3-[4-(2,3-... 2 41
Nuclear receptor ROR-gamma and Menin ligand CHEMBL1432265 family 1 18
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 2
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 4 4
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 3 8
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 3
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 7 4
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 5 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 1
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 7 9
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 11 9
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 6 16
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 7
Prelamin-A/C and Cruzipain inhibitor CHEMBL1598118 family 1 3
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 4 2
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
C5a anaphylatoxin chemotactic receptor 1 ligand N-[(4-dimethyl... 1 4
Potassium voltage-gated channel subfamily H member 2 and Melan... 9 4
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 3 2
Prostaglandin E2 receptor EP4 subtype ligand AGN-PC-09QMLE family 5 0
DNA-dependent protein kinase catalytic subunit and Phosphatidy... 1 6
3-oxo-5-alpha-steroid 4-dehydrogenase 1 inhibitor N-[(1S,5aR,9... 2 2
Vasopressin V1b receptor ligand AGN-PC-09QGT9 family 4 123
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 2
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 4 1
Androgen receptor ligand (2R)-2-ethyl-1-(2,2,2-trifluoroethyl)... 32 6
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand CHEMB... 13 20
Prostaglandin D2 receptor and Prostacyclin receptor ligand 2-[... 15 5
Neuropeptide Y receptor type 5 ligand 2-(7-chloro-3-oxo-1,4-be... 3 3
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 1 0
Transient receptor potential cation channel subfamily V member... 1 0
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 3
MAP kinase-activated protein kinase 2 inhibitor 5-(4-cyanophen... 3 8
Glycogen synthase kinase-3 beta inhibitor CHEMBL1940979 family 1 0
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 2 0
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Cathepsin L1 and Cathepsin S inhibitor arylaminoethyl amide, 5... 4 5
Cathepsin S and Cathepsin K inhibitor arylaminoethyl amide, 7 ... 2 0
Growth hormone secretagogue receptor type 1 ligand (2R)-N-(1-b... 11 4
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 1
Microsomal triglyceride transfer protein large subunit inhibit... 3 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
Motilin receptor ligand SureCN14564469 family 1 6
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 3
Potassium voltage-gated channel subfamily H member 2 and Melan... 5 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand CHEMB... 6 3
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand CHEMB... 2 2
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 2 1
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 2
Receptor-type tyrosine-protein kinase FLT3 ligand (3Z)-5-chlor... 1 4
Bifunctional epoxide hydrolase 2 inhibitor 3-[4-[[4-(trifluoro... 5 22
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 6 11
C-X-C chemokine receptor type 3 ligand N-(2-ethoxyethyl)-N-[(1... 1 1
Sodium-dependent serotonin transporter and D(2) dopamine recep... 8 6
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 1
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 5 8
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 10
Bifunctional epoxide hydrolase 2 and RAF proto-oncogene serine... 4 10
Poly [ADP-ribose] polymerase 1 inhibitor 3-chloro-N-cyclopropy... 1 2
Poly [ADP-ribose] polymerase 1 inhibitor N-ethyl-4-[4-[(8-meth... 1 0
Serine/threonine-protein kinase Chk1 inhibitor 2-[9-(4-amino-3... 5 2
E3 ubiquitin-protein ligase XIAP and Cytochrome P450 3A4 inhib... 1 2
Bifunctional epoxide hydrolase 2 inhibitor 8-(2,6-difluorobenz... 4 1
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 1 2
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 1 5
Glutamate receptor ionotropic, NMDA 2B and Potassium voltage-g... 2 1
Kinesin-like protein KIF11 and Potassium voltage-gated channel... 10 2
Progesterone receptor ligand CHEMBL252850 family 2 0
Alpha-1D adrenergic receptor and D(2) dopamine receptor ligand... 3 0
5-hydroxytryptamine receptor 1A ligand SureCN10513645 family 9 1
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 11
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
Delta-type opioid receptor and Kappa-type opioid receptor liga... 5 0
D(3) dopamine receptor and D(4) dopamine receptor ligand SureC... 3 19
5-hydroxytryptamine receptor 1A ligand 3-hydroxy-6-iodo-2-[2-[... 2 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 2
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 7 10
Neprilysin and Angiotensin-converting enzyme inhibitor 2-[(3S)... 5 6
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 4 4
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
Mu-type opioid receptor ligand AGN-PC-00NCMO family 3 1
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 1 0
Urotensin-2 receptor ligand SureCN4431593 family 1 7
Glucagon receptor and Adenylate cyclase type 1 ligand AGN-PC-0... 3 1
Pol polyprotein inhibitor AC1LA3B0 family 1 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 16 2
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-00RZQT family 3 4
Histamine H3 receptor ligand AGN-PC-00AE5Q family 13 13
Acyl-CoA desaturase 1 inhibitor AGN-PC-077KJY family 5 4
Acyl-CoA desaturase 1 inhibitor AGN-PC-077KFD family 1 1
Histamine H3 receptor and Potassium voltage-gated channel subf... 28 30
Mitogen-activated protein kinase 14 inhibitor SureCN4822166 fa... 1 4
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 5 5
Leukotriene A-4 hydrolase inhibitor SureCN5313952 family 4 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 12
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 1 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 1 0
Cathepsin E and Cathepsin D inhibitor SureCN2529506 family 2 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 1
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 1 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 2 9
Mitogen-activated protein kinase 14 inhibitor AGN-PC-00A4QT fa... 2 0
Mitogen-activated protein kinase 14 inhibitor ITX 5061 free ba... 2 3
Beta-1 adrenergic receptor and Beta-3 adrenergic receptor liga... 2 0
Mineralocorticoid receptor and Glucocorticoid receptor ligand ... 2 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 2 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 1 0
Cyclin-dependent kinase 4 inhibitor SureCN3563106 family 1 1
Sterol O-acyltransferase 1 inhibitor SureCN5812305 family 1 0
Thioredoxin glutathione reductase and Microtubule-associated p... 1 2
Huntingtin and Retinal dehydrogenase 1 inhibitor CHEMBL1467512... 1 0
Hypoxia-inducible factor 1-alpha inhibitor 2-morpholin-4-yleth... 2 0
Sodium channel protein type 1 subunit alpha and Sodium channel... 3 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 1
4-(4-methoxyphenyl)-2,4,5,10-tetrahydro-1H-pyrrolo[3,4-c][1,5]... 4 0
Putative NP ZINC17112928 Family 5 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00243638 CHEMBL61440 Bioactive 2,3-dihydroindol-1-yl-[3-[[4-(2-propan-2-yloxyphenyl)piperazin-1-yl]methyl]phenyl]methanone
CFAMM00243614 CHEMBL292107 Bioactive SureCN13533238
CFAMM00243634 DNC012338 Investigative Drug MAZAPERTINE
CFAMM00243661 DNC004934 Investigative Drug UPIDOSIN
CFAMM00243669 DNC005570 Investigative Drug BP-897

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

22854 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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