CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1581
Family Name Alpha-1A adrenergic receptor Ligand A-131701 Family
No. of Seeds 16 No. of Other Members 17
Family Centroid CFAMM00243992 Functional Category Investigative Drug with Natural Product
Superfamily Alpha-1A adrenergic receptor Ligand A-131701 Superfamily
Class Class 985

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Disintegrin and metalloproteinase domain-containing protein 17... 14 9
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 14
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Disintegrin and metalloproteinase domain-containing protein 17... 2 8
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 3 5
Receptor-type tyrosine-protein kinase FLT3 and Vascular endoth... 4 4
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
Disintegrin and metalloproteinase domain-containing protein 17... 4 1
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 2 15
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 11
Renin inhibitor [2-(3-fluoro-2,6-dimethylphenoxy)-1-phenylpyrr... 5 12
D(2) dopamine receptor and Alpha-1B adrenergic receptor ligand... 3 4
MAP kinase-activated protein kinase 2 inhibitor N-[4-(4-oxospi... 3 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 8 4
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 23 10
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... 1 3
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
Disintegrin and metalloproteinase domain-containing protein 17... 5 4
Bifunctional epoxide hydrolase 2 inhibitor 8-(quinoline-5-carb... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 8-[(6,7... 6 8
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 1 1
Platelet-activating factor receptor ligand N,N-dimethyl-6-phen... 12 18
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 1
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 2 1
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
C-C chemokine receptor type 8 and Potassium voltage-gated chan... 5 1
Mitogen-activated protein kinase 14 inhibitor SureCN4508019 fa... 1 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 1 0
Signal transducer and activator of transcription 1-alpha/beta ... 1 36
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00243967 CHEMBL40754 Bioactive 3-[2-[(3aR,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl]ethyl]-1H-pyrido[2,3]thieno[2,4-b]pyrimidine-2,4-dione
CFAMM00243981 CHEMBL289437 Bioactive 3-[2-[(3aR,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl]ethyl]-6-chloro-1H-pyrido[1,2]thieno[3,4-b]pyrimidine-2,4-dione
CFAMM00243994 CHEMBL287928 Bioactive 3-[2-[(3aR,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl]ethyl]-6-methoxy-1H-pyrido[1,2]thieno[3,4-b]pyrimidine-2,4-dione
CFAMM00243979 CHEMBL290387 Bioactive 3-[2-[(3aR,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl]ethyl]-8-chloro-1H-pyrazino[1,2]thieno[3,4-b]pyrimidine-2,4-dione
CFAMM00243986 CHEMBL43909 Bioactive 3-[2-[(3aR,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl]ethyl]-8-phenyl-1H-pyrazino[1,2]thieno[3,4-b]pyrimidine-2,4-dione
CFAMM00243965 CHEMBL41234 Bioactive 3-[2-[(3aR,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl]ethyl]-8-methoxy-1H-pyrido[3,4]thieno[1,3-b]pyrimidine-2,4-dione
CFAMM00243991 CHEMBL287965 Bioactive 3-[2-[(3aR,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl]ethyl]-1H-pyrido[2,3]thieno[2,4-b]pyrimidine-2,4-dione
CFAMM00243984 CHEMBL297218 Bioactive 3-[2-[(3aR,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl]ethyl]-7-methyl-1H-pyrazino[1,2]thieno[3,4-b]pyrimidine-2,4-dione
CFAMM00243990 CHEMBL291262 Bioactive 3-[2-[(3aR,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl]ethyl]-1H-pyrido[2,3]thieno[2,4-b]pyrimidine-2,4-dione
CFAMM00243975 CHEMBL441032 Bioactive 3-[2-[(3aR,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl]ethyl]-8-methoxy-1H-pyrazino[1,2]thieno[3,4-b]pyrimidine-2,4-dione
CFAMM00243968 CHEMBL40896 Bioactive CHEMBL40896
CFAMM00243982 CHEMBL299907 Bioactive 3-[2-[(3aR,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl]ethyl]-1H-pyrido[3,2-d]pyrimidine-2,4-dione
CFAMM00243996 CHEMBL295741 Bioactive 3-[2-[(3aR,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl]ethyl]-8-chloro-1H-pyrido[3,4]thieno[1,3-b]pyrimidine-2,4-dione
CFAMM00243974 CHEMBL290243 Bioactive 3-[2-[(3aR,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl]ethyl]-7,8-dimethyl-1H-pyrazino[3,4]thieno[1,3-b]pyrimidine-2,4-dione
CFAMM00243988 CHEMBL288530 Bioactive 3-[2-[(3aR,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl]ethyl]-1H-pyrazino[1,2]thieno[3,4-b]pyrimidine-2,4-dione
CFAMM00243992 DNC004941 Investigative Drug A-131701

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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