CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1582
Family Name Alpha-1A adrenergic receptor Ligand Naftopidil Family
No. of Seeds 15 No. of Other Members 119
Family Centroid CFAMM00244023 Functional Category Investigative Drug with Natural Product
Superfamily Alpha-1A adrenergic receptor Ligand Naftopidil Superfamily
Class Class 1071

Cousin Family NamesSeedsMembers
D(1B) dopamine receptor Ligand Apomorphine Family 30 271
Squalene monooxygenase Inhibitor Tolnaftate Family 1 4
Cholesteryl ester transfer protein Inhibitor CP-800569 Family 5 81
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 3 27
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 3 67
Substance-P receptor Ligand Ezlopitant Family 10 207
D(2) dopamine receptor Ligand Pardoprunox Family 4 81
D(4) dopamine receptor Ligand PD-165167 Family 2 96
Tumor necrosis factor Inhibitor Tgaac-94 Family 6 107
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
Muscarinic acetylcholine receptor M1 Ligand AC-260584 Family 4 36
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
C-C chemokine receptor type 1 Ligand BX-471 Family 10 67
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
Alpha-1 adrenergic receptor Ligand DC-015 Family 8 25
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
5-hydroxytryptamine receptor 6 Ligand Sb 258585 Family 11 121
Multidrug resistance protein Inhibitor MM36 Family 1 1
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
Leukotriene A-4 hydrolase Inhibitor N-benzyl-4-[(2r)-pyrrolidi... 6 40
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 18 12
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor Liga... 40 90
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 6 23
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 131
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand RWJ-68141 Family 5 4
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Peroxisome proliferator-activated receptor gamma and Peroxisom... 1 31
Amyloid beta A4 protein Inhibitor 6-iodo-4'-methylaminoflavone... 3 33
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 41
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
Macrophage migration inhibitory factor Inhibitor 3-benzyl-5-me... 10 42
Amine oxidase [flavin-containing] B Inhibitor N-methyl-n-pheny... 6 25
Sodium-dependent serotonin transporter Inhibitor 4-(2-((dimeth... 3 1
Sodium-dependent noradrenaline transporter Inhibitor WAY-25680... 4 6
5-hydroxytryptamine receptor 2A and D(1A) dopamine receptor Li... 8 33
Cholesteryl ester transfer protein Inhibitor Tetrahydroquinoli... 3 8
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-(3-morpholinop... 24 102
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 8 41
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-237... 21 56
Leukotriene A-4 hydrolase Inhibitor 1-[4-(4-iodophenoxy)phenyl... 5 18
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 28
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
Acetylcholinesterase Inhibitor 6-methyl-4-(4-phenylpiperazin-1... 6 622
Estrogen receptor and Estrogen receptor beta ligand AGN-PC-00G... 16 4
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 6
D(4) dopamine receptor ligand AGN-PC-004XJQ family 2 1
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 1
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
D(2) dopamine receptor ligand 7-[4-[4-(2-ethoxyphenyl)piperazi... 12 14
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 14 12
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 5 13
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(4-... 3 5
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 6 2
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 3 6
Alpha-2A adrenergic receptor and 5-hydroxytryptamine receptor ... 7 10
D(4) dopamine receptor and D(2) dopamine receptor ligand 7-[[4... 1 23
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 3 2
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 2 0
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 8 0
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-N... 2 2
Estrogen receptor and Estrogen receptor beta ligand SureCN5681... 7 3
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 4 8
Neuropeptide S receptor and Prelamin-A/C ligand CHEMBL1352632 ... 1 25
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 1 0
Multidrug resistance protein 1 inhibitor 1-[2-[(2R)-3-[4-(2,3-... 2 41
Nischarin inhibitor SureCN7818902 family 2 12
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 3
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 7 4
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 5 0
5-hydroxytryptamine receptor 6 ligand AGN-PC-0BRZ7B family 9 2
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 2 9
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 4 2
C5a anaphylatoxin chemotactic receptor 1 ligand N-[(4-dimethyl... 1 4
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 11 4
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 2
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 3 0
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 4 1
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 6 1
Androgen receptor ligand (2R)-2-ethyl-1-(2,2,2-trifluoroethyl)... 32 6
Histamine H3 receptor and Sodium-dependent serotonin transport... 15 1
Neuropeptide Y receptor type 5 ligand N-[[4-[2-[7-(trifluorome... 1 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 28
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 5
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 2 0
Androgen receptor ligand AGN-PC-00BRQF family 2 2
Sodium-dependent serotonin transporter inhibitor 2-[2-[(dimeth... 3 3
Translocator protein inhibitor AGN-PC-00CH84 family 3 0
Translocator protein inhibitor [11C]DAA1106 family 15 2
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 1 3
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 1 0
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 6 11
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
C-C chemokine receptor type 1 ligand N-[2-[(2S)-3-(5-chlorospi... 4 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 1
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
5-hydroxytryptamine receptor 7 ligand 1-(2-methoxyphenyl)-4-[2... 6 2
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 1
D(3) dopamine receptor and D(2) dopamine receptor ligand (5R)-... 2 0
Glutamate receptor ionotropic, NMDA 2B and Potassium voltage-g... 2 1
Somatostatin receptor type 1 and D(4) dopamine receptor ligand... 9 10
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 7 1
Kinesin-like protein KIF11 and Potassium voltage-gated channel... 10 2
Progesterone receptor ligand CHEMBL252850 family 2 0
D(2) dopamine receptor and Alpha-1B adrenergic receptor ligand... 2 2
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 11
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 1A ligand AGN-PC-0034EG family 5 2
5-hydroxytryptamine receptor 1A ligand (1R,2R)-2-[4-(2,3-dihyd... 2 3
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 7 10
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Substance-P receptor ligand CP 141938 family 1 0
Estrogen receptor and Estrogen receptor beta ligand SureCN6716... 2 0
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 5 5
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 12
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 1 0
Histamine H3 receptor ligand SureCN3057839 family 1 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 0
D(4) dopamine receptor and 5-hydroxytryptamine receptor 2C lig... 1 7
Estrogen receptor beta and Estrogen receptor ligand (E)-3-[4-(... 1 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 2 9
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 2 8
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 2 6
Sterol O-acyltransferase 1 inhibitor SureCN5812305 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00244051 CHEMBL242817 Bioactive SureCN1035562
CFAMM00244135 CHEMBL1593765 Bioactive NAFTOPIDIL DIHYDROCHLORIDE
CFAMM00244113 CHEMBL239231 Bioactive 1-(2-methoxyphenyl)-4-[2-[3-[2-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]phenoxy]ethoxy]phenyl]ethyl]piperazine
CFAMM00244049 CHEMBL135135 Bioactive SureCN8639256
CFAMM00244021 CHEMBL395444 Bioactive 1-(2-methoxyphenyl)-4-[2-[3-[2-[2-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]phenoxy]ethoxy]ethoxy]phenyl]ethyl]piperazine
CFAMM00244023 DNC004943 Investigative Drug NAFTOPIDIL

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

48712 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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