CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
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CFam Family Information

CFAM Family ID CFFID1587
Family Name 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine receptor 2B Ligand ATC-0175 Family
No. of Seeds 19 No. of Other Members 103
Family Centroid CFAMM00244234 Functional Category Investigative Drug with Natural Product
Superfamily Adenosine receptor A3 and 5-hydroxytryptamine receptor 1A Binder Superfamily
Class Class 824

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand be... 4 301
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
HIV protease Inhibitor Saquinavir Family 64 428
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Reverse transcriptase Inhibitor Nevirapine Family 23 640
5-hydroxytryptamine receptor Ligand Ramosetron Family 10 219
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Peptide deformylase, mitochondrial inhibitor folic acid analog... 59 98
Histamine H1 receptor Ligand Mizolastine Family 14 603
Prothrombin Inhibitor Dabigatran Family 7 182
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 5 129
Transient receptor potential cation channel subfamily V member... 15 457
Neuromedin-K receptor Ligand SB222200 Family 17 235
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Mitogen-activated protein kinase 12 Inhibitor VX-702 Family 3 49
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Cannabinoid receptor 1 Ligand AZD2207 Family 18 48
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Dipeptidyl peptidase 4 Inhibitor Linagliptin Family 10 81
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
Translocator protein Inhibitor Emapunil Family 7 89
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Substance-P receptor Ligand TAK-637 Family 18 63
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
RAC-gamma serine/threonine-protein kinase Inhibitor GDC-0068 F... 20 29
BIBT986 family 7 96
Serine/threonine-protein kinase mTOR Inhibitor AZD2014 Family 2 41
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
IPI-145 family 2 4
Histone deacetylase Inhibitor JNJ-26481585 Family 2 5
Casein kinase II subunit alpha Inhibitor CX-4945 Family 1 7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 37 10
Vascular endothelial growth factor receptor 1 and Angiopoietin... 29 127
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
PHA848125 family 13 138
CP-18770 family 6 27
Smoothened homolog Inhibitor LY2940680 Family 3 18
Tyrosine-protein kinase BTK Inhibitor CC-292 Family 6 10
CC-486 family 7 103
JAK Inhibitor Momelotinib Family 33 83
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
XL-888 family 16 85
PF-4136309 family 16 27
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
Platelet activating factor, putative Inhibitor ABT-491 Family 22 62
Bacterial outer membrane Inhibitor HKI-9924129 Family 19 85
Class II cytokine receptor Ligand IL-10 Family 7 45
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
5-hydroxytryptamine receptor 2B Ligand MT-500 Family 8 39
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Olprin... 2 7
Cyclin-dependent kinase 4 and Cyclin-dependent kinase 6 Inhibi... 2 3
Epidermal growth factor receptor and Receptor tyrosine-protein... 11 138
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 32
Peptide deformylase, mitochondrial Inhibitor 5-phenethyl-quina... 5 14
Tubulin beta chain Inhibitor 7-methyl-2-m-tolyl-1h-[1,8]naphth... 7 15
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Integrin alpha-V and Integrin beta-3 Inhibitor SB-223245 Family 27 36
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Epidermal growth factor receptor Ligand N*4*-(3-bromo-phenyl)-... 7 11
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Cyclin-dependent kinase 4 Inhibitor 1-(9-oxo-9h-fluoren-4-yl)-... 3 5
Epidermal growth factor receptor Ligand Benzo[g]quinazolin-4-y... 5 3
Epidermal growth factor receptor Ligand (3-bromo-phenyl)-quina... 7 5
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 93
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
Epidermal growth factor receptor Ligand N4-(3-chlorophenyl)qui... 7 39
D(2) dopamine receptor and D(3) dopamine receptor Ligand A-706... 4 20
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Poly [ADP-ribose] polymerase 1 Inhibitor 2-ethylquinoline-8-ca... 3 4
Cyclin-dependent kinase 2 and Mitogen-activated protein kinase... 7 30
Metabotropic glutamate receptor 5 Ligand 3-chloro-n-(6-chlorop... 2 5
Metabotropic glutamate receptor 5 Ligand 3-cyano-n-(6-methylpy... 4 3
Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... 2 9
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
Transient receptor potential cation channel subfamily V member... 6 23
Adenosine receptor A1 Ligand N-(4,6-diphenylpyrimidin-2-yl)ben... 4 8
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2,6... 22 18
Mitogen-activated protein kinase 8 Inhibitor 2-(2-phenoxypyrim... 12 30
Microsomal triglyceride transfer protein large subunit Inhibit... 5 9
Adenosine receptor A3 Ligand 2-aminoquinazoline-4-carboxyanili... 4 3
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 2 3
Histamine H4 receptor Ligand A-943931 Family 14 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Arachidonate 5-lipoxygenase Inhibitor Methyl 2-(benzylamino)-1... 3 10
Adenosine receptor A1 and Adenosine receptor A2a Ligand OSIP-3... 4 31
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Calcitonin gene-related peptide type 1 receptor Ligand Isomer ... 30 31
Hydroxycarboxylic acid receptor 2 Ligand 2-(6-phenylhexyl)pyri... 4 11
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Urotensin-2 receptor Ligand Palosuran Family 4 4
Type-2 angiotensin II receptor Ligand L-158282 Family 24 58
Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... 5 35
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... 6 16
Metabotropic glutamate receptor 5 Ligand 3-cyano-5-fluoro-n-(p... 2 9
Tubulin beta chain Inhibitor 2-m-tolyl-1h-[1,8]naphthyridin-4-... 5 2
RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90
Protein kinase C alpha type Inhibitor Dequalinium Analogue Family 1 10
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 6-(4-... 3 6
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 11
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 2
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 8
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 3
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 1 8
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 1 4
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07ZYJE fa... 15 5
Rho-associated protein kinase 2 and cAMP-dependent protein kin... 2 7
Sphingosine 1-phosphate receptor 1 ligand SureCN3029336 family 4 8
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
Orexin receptor type 2 and Orexin receptor type 1 ligand [(7R)... 10 10
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 4 14
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 3
Sphingosine 1-phosphate receptor 5 and Sphingosine 1-phosphate... 2 0
Adenosine receptor A2a and Adenosine receptor A1 ligand 2-amin... 10 48
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 13 1
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Glycogen synthase kinase-3 beta inhibitor AGN-PC-07ZA4D family 1 0
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 6 0
Mitogen-activated protein kinase 14 inhibitor SureCN3632376 fa... 10 5
Mitogen-activated protein kinase 13 inhibitor N-cyclopropyl-3-... 16 40
Epidermal growth factor receptor ligand AGN-PC-07Q1HU family 4 17
Adenosine receptor A3 and Adenosine receptor A2a ligand AGN-PC... 3 18
Adenosine receptor A3 ligand AGN-PC-07N4XX family 6 10
Adenosine receptor A3 and Adenosine receptor A1 ligand AGN-PC-... 5 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 12
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 2 4
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-07ZE3... 6 1
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 7 0
C-C chemokine receptor type 5 ligand [3-[2-[(3aS,6aR)-5-(4,6-d... 3 40
Integrin beta-3 and Integrin alpha-V inhibitor SureCN547914 fa... 8 32
Thymidylate synthase inhibitor (2R)-2-[[(4S)-4-carboxy-4-[[4-[... 55 43
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 7 58
Integrin beta-3 and Integrin alpha-V inhibitor SureCN3888804 f... 11 13
ALK tyrosine kinase receptor ligand SureCN1600195 family 1 1
Platelet-activating factor receptor ligand SureCN9384429 family 11 3
RAC-alpha serine/threonine-protein kinase inhibitor SureCN4728... 11 6
Platelet-activating factor receptor ligand 8-bromo-2-[4-(2-met... 2 2
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 13
Smoothened homolog inhibitor SureCN1091571 family 2 2
Substance-P receptor ligand (3R,4S)-N-[[3,5-bis(trifluoromethy... 3 7
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Tyrosine-protein kinase ABL1 and Mitogen-activated protein kin... 1 3
Transient receptor potential cation channel subfamily V member... 1 4
Serine/threonine-protein kinase D1 inhibitor SureCN1424142 family 13 8
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 1 0
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
Caspase-1 inhibitor (3S)-3-[[(2S)-4-[2-(1,2-dimethylindol-3-yl... 3 4
Histamine H3 receptor ligand 1-[1-[1-[(2-aminopyridin-4-yl)met... 16 9
Disintegrin and metalloproteinase domain-containing protein 17... 2 11
Melanin-concentrating hormone receptor 1 and Potassium voltage... 8 27
Melanin-concentrating hormone receptor 1 ligand AGN-PC-088XRP ... 2 10
Mitogen-activated protein kinase 14 inhibitor 3mvm family 6 1
Cathepsin K and Potassium voltage-gated channel subfamily H me... 4 7
Thymidylate synthase inhibitor AC1LAB82 family 17 0
Tyrosine-protein kinase ABL1 inhibitor 5-[(5-{[4-{[4-(2-Hydrox... 4 1
TGF-beta receptor type-1 ligand 6-[4-ethyl-2-(6-methylpyridin-... 9 11
Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-4-... 4 10
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 2 4
Serine/threonine-protein kinase mTOR and RAC-alpha serine/thre... 3 3
Mitogen-activated protein kinase kinase kinase kinase 5 and Du... 1 18
Cathepsin K and Potassium voltage-gated channel subfamily H me... 3 1
Adenosine receptor A2a ligand SureCN14156209 family 3 2
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-09M45... 8 1
Cathepsin K and Potassium voltage-gated channel subfamily H me... 5 1
Coagulation factor X inhibitor AGN-PC-075AY8 family 28 21
Cell division cycle 7-related protein kinase inhibitor pyrrolo... 4 10
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
5-hydroxytryptamine receptor 1A ligand AGN-PC-03ZB72 family 10 8
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 19
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M6OU fa... 8 7
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 13 1
Tyrosine-protein kinase JAK2 and Potassium voltage-gated chann... 2 7
Mitogen-activated protein kinase 14 inhibitor AGN-PC-069K8I fa... 12 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 3 6
Mitogen-activated protein kinase 1 and Cytochrome P450 3A4 inh... 1 0
Adenosine receptor A2a ligand AGN-PC-077RWY family 4 5
Dihydrofolate reductase and Thymidylate synthase inhibitor 2-[... 10 5
C-C chemokine receptor type 5 ligand SureCN1573831 family 4 3
Peroxisome proliferator-activated receptor gamma ligand 1-[(4-... 7 29
Translocator protein inhibitor (2E)-N-(4-chlorophenyl)-N-methy... 2 13
Glucosylceramidase and Alpha-galactosidase A inhibitor AC1NNEG... 4 5
G1/S-specific cyclin-D1 and G1/S-specific cyclin-D3 inhibitor ... 6 3
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 1
Dihydrofolate reductase inhibitor 2-[[4-carboxy-4-[[4-[(2,4-di... 3 1
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 1
Survival motor neuron protein and Muscleblind-like protein 1 i... 1 3
Cellular tumor antigen p53 inhibitor CHEMBL1551403 family 1 0
Survival motor neuron protein inhibitor CHEMBL1583999 family 1 3
Prelamin-A/C and Cellular tumor antigen p53 inhibitor CHEMBL16... 1 7
Metabotropic glutamate receptor 2 ligand AGN-PC-09QJ9P family 2 7
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 5 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 1
RAC-alpha serine/threonine-protein kinase inhibitor 2-[(4-chlo... 11 2
RAC-alpha serine/threonine-protein kinase inhibitor 2-[(3,4-di... 3 1
Hepatocyte growth factor receptor and Insulin receptor ligand ... 4 15
Aurora kinase A inhibitor AGN-PC-00EHLC family 1 0
Dipeptidyl peptidase 4 inhibitor 3-[6-[(3R,4S)-3-amino-4-(2,4,... 3 7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
Insulin-like growth factor 1 receptor ligand AGN-PC-09QGLU family 3 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 34 4
Dipeptidyl peptidase 4 inhibitor AGN-PC-09QKOM family 5 8
C-X-C chemokine receptor type 3 ligand SureCN13205646 family 4 0
Microsomal triglyceride transfer protein large subunit inhibit... 7 4
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family 8 15
C-C chemokine receptor type 5 ligand SureCN3684128 family 2 2
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 3 3
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 2 2
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
Signal transducer and activator of transcription 6 inhibitor A... 3 0
Substance-P receptor and Neuromedin-K receptor ligand SureCN88... 4 14
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 0
Tyrosine-protein kinase ITK/TSK and Receptor-type tyrosine-pro... 1 0
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor dihydro-benz... 1 4
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 15 7
Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 3 5
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801305 ... 2 0
Mitogen-activated protein kinase 9 and MAP kinase-activated pr... 1 0
Mitogen-activated protein kinase 14 inhibitor N-ethyl-5-methyl... 17 3
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 13 3
Dihydrofolate reductase inhibitor 1-[3-(2,4-diaminoquinazolin-... 2 4
B1 bradykinin receptor ligand AGN-PC-005XAO family 3 17
Beta-secretase 1 inhibitor 3-[2-amino-6-(2-methylphenyl)quinol... 5 2
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 3 0
Coagulation factor X inhibitor AGN-PC-0749BY family 5 9
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 7 1
B1 bradykinin receptor ligand 6-(8-fluoro-4-methyl-1-oxophthal... 3 0
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 1
TGF-beta receptor type-1 ligand 3-[[3-(6-methylpyridin-2-yl)-4... 1 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 0
Histamine H3 receptor ligand SureCN2878688 family 8 1
Protein-tyrosine kinase 6 and KH domain-containing, RNA-bindin... 21 6
Coagulation factor X and Coagulation factor IX inhibitor pyraz... 11 0
Coagulation factor X and Coagulation factor IX inhibitor pyraz... 6 1
Corticotropin-releasing factor receptor 1 ligand 3-chloro-4-[8... 7 1
Mitogen-activated protein kinase 14 inhibitor SureCN3305171 fa... 1 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 3 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 7 12
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 18 5
Histamine H1 receptor and Histamine H4 receptor ligand [4-[2-[... 1 1
Translocator protein inhibitor N-(4-chlorophenyl)-N-methyl-2-(... 2 0
Transient receptor potential cation channel subfamily V member... 2 1
Heat shock protein HSP 90-beta inhibitor N-[(9R)-4-(3H-imidazo... 1 0
Hepatocyte growth factor receptor ligand 5-[[6-(1-methylpyrazo... 4 0
Hepatocyte growth factor receptor ligand 5-[(6-phenyl-[1,2,4]t... 6 2
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 9 6
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
Coagulation factor X inhibitor SureCN8289965 family 4 5
Ribosomal protein S6 kinase alpha-3 inhibitor N-(3-ethylimidaz... 2 2
3-phosphoinositide-dependent protein kinase 1 and RAC-alpha se... 10 4
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 3 2
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 7 1
Dipeptidyl peptidase 4 and Potassium voltage-gated channel sub... 9 0
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 10 0
Mitogen-activated protein kinase 14 inhibitor ethyl N-[4-[5-(m... 5 2
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 3
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Vascular endothelial growth factor receptor 1 and Vascular end... 4 0
Casein kinase II subunit alpha and Serine/threonine-protein ki... 1 5
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 3 4
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 1 1
Aurora kinase B and Aurora kinase A inhibitor 4-amino-N-[3-[[(... 5 3
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 3 0
Protein kinase C theta type and Leucine-rich repeat serine/thr... 1 1
5-hydroxytryptamine receptor 3A ligand 3-methyl-N-[7-[[3-methy... 2 0
Heat shock protein HSP 90-beta inhibitor 1-(2-amino-4-methylqu... 1 2
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Vascular endothelial growth factor receptor 2 ligand (3Z)-6-fl... 4 3
Transient receptor potential cation channel subfamily V member... 4 0
C-C chemokine receptor type 4 ligand [4-[4-[(2,4-dichloropheny... 4 4
Epidermal growth factor receptor ligand (2R,3R)-3-[[4-(3-bromo... 3 0
Dipeptidyl peptidase 4 inhibitor 2-[[2-[(3R)-3-aminopiperidin-... 1 0
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 8 5
Epidermal growth factor receptor ligand N-[3-[3-methyl-7-[4-(4... 2 1
Aurora kinase A and Aurora kinase B inhibitor [4-[[7-cyclopent... 6 0
Hematopoietic prostaglandin D synthase inhibitor 4-(3-methylis... 1 7
Substance-P receptor ligand 2-[3,5-bis(trifluoromethyl)phenyl]... 3 1
Oxytocin receptor ligand (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)... 20 2
Egl nine homolog 2 and Egl nine homolog 1 inhibitor 8-[(3-meth... 3 1
Protein kinase C theta type inhibitor (2-aminopyridin-3-yl)-[6... 4 1
Glycogen synthase kinase-3 beta inhibitor N-[2-[4-(ethylsulfon... 3 1
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Growth hormone secretagogue receptor type 1 ligand SureCN62436... 8 6
Translocator protein inhibitor N-butan-2-yl-4-(2-chlorophenyl)... 14 12
Poly [ADP-ribose] polymerase 1 inhibitor 8-[[4-fluoro-3-(4-pyr... 5 2
DNA gyrase subunit B inhibitor 5-[2-(ethylcarbamoyl)-4-[3-(tri... 2 4
Substance-P receptor ligand Netupitant family 5 2
Lysine--tRNA ligase inhibitor N-[2-(2-piperazin-1-ylpyridin-4-... 5 0
Lysine--tRNA ligase inhibitor 4-[[2-(2-piperazin-1-ylpyridin-4... 2 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor (2... 16 5
Aurora kinase A and Aurora kinase B inhibitor 4-fluoro-N-[4-[(... 6 1
B1 bradykinin receptor ligand methyl 2-[4-[(1R)-1-[[3-[(2-cyan... 8 7
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 2 0
Melanin-concentrating hormone receptor 1 ligand 6-(4-chlorophe... 8 1
Mitogen-activated protein kinase 14 inhibitor pyrimido-pyrimid... 15 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-0762YG family 2 2
Renin inhibitor AGN-PC-073MLF family 7 6
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 3 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 0
Microsomal triglyceride transfer protein large subunit inhibit... 13 0
Melanin-concentrating hormone receptor 1 ligand SureCN4261878 ... 4 7
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 2
Beta-secretase 1 and Beta-secretase 2 inhibitor 5-[(1R)-3-amin... 8 1
Succinate receptor 1 ligand N-[[4-(3-methylphenyl)phenyl]methy... 2 14
Melanin-concentrating hormone receptor 1 ligand SureCN6198980 ... 13 0
Smoothened homolog inhibitor N-[4-methyl-3-(5-phenyl-1H-imidaz... 1 0
Smoothened homolog inhibitor 3-pyridin-3-yl-N-[1-[[6-[4-[(3-py... 1 0
Eukaryotic translation initiation factor 2-alpha kinase 3 inhi... 11 2
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 2 0
Transient receptor potential cation channel subfamily V member... 57 4
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 2 0
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 12 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 17 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase ITK/TS... 4 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547496 f... 2 1
Neuromedin-K receptor and Potassium voltage-gated channel subf... 13 2
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17d ... 5 9
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 2 0
Serine/threonine-protein kinase TBK1 and 3-phosphoinositide-de... 3 3
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
P2X purinoceptor 7 inhibitor SureCN109432 family 10 28
P2X purinoceptor 7 inhibitor SureCN109149 family 8 1
B1 bradykinin receptor ligand N-[4-chloro-2-[[(1R)-1-[4-[3-flu... 5 5
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-(3-methy... 2 5
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-(6-pyrrolid... 3 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (4-am... 2 1
Adenosine kinase inhibitor 4-[2-[5-(4-chlorophenyl)-6-piperazi... 3 1
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor 6-... 1 0
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 2
Melanocortin receptor 4 ligand AGN-PC-076AMO family 17 8
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 6 0
G-protein coupled bile acid receptor 1 ligand 2-(ethylamino)-6... 5 4
Serine/threonine-protein kinase mTOR inhibitor 2-[4-[4-[(3S)-3... 3 0
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Epithelial discoidin domain-containing receptor 1 and Mast/ste... 1 0
Disintegrin and metalloproteinase domain-containing protein 17... 7 9
Disintegrin and metalloproteinase domain-containing protein 17... 2 1
Metabotropic glutamate receptor 5 ligand 5-(4-fluorophenyl)-1,... 7 1
Dipeptidyl peptidase 4 inhibitor 2-[(3R)-3-aminopiperidin-1-yl... 3 4
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-(6-fluoro... 5 1
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Motilin receptor ligand SureCN2768052 family 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Non-receptor tyrosine-protein kinase TYK2 ligand AGN-PC-0D0YSZ... 10 0
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C9 inhib... 3 0
Acetylcholinesterase inhibitor N-[6-[4-[(6-chloro-1,2,3,4-tetr... 9 0
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 7 7
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 0
C-C chemokine receptor type 5 ligand N-[3-[4-[3-cyclohexyl-5-(... 5 4
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 2 0
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 4 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 4-[4... 1 1
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 3 0
Disintegrin and metalloproteinase domain-containing protein 17... 3 0
Disintegrin and metalloproteinase domain-containing protein 17... 10 4
C-X-C chemokine receptor type 3 ligand AGN-PC-07CQOB family 17 10
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 3 0
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 4 3
Disintegrin and metalloproteinase domain-containing protein 17... 4 0
Tyrosine-protein kinase Lck and Mitogen-activated protein kina... 2 7
Macrophage colony-stimulating factor 1 receptor and Mast/stem ... 27 4
Metabotropic glutamate receptor 2 ligand 8-(2,5-difluorophenyl... 6 2
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 1
Casein kinase II subunit alpha inhibitor CHEMBL401945 family 12 1
C-X-C chemokine receptor type 3 ligand 1-[3-[[(1R,5S)-3-[[7-(t... 3 1
Coagulation factor X inhibitor AGN-PC-078Y0S family 7 1
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 7 2
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 0
Substance-P receptor ligand AGN-PC-004REJ family 3 0
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-(3-fluor... 10 0
Folylpolyglutamate synthase, mitochondrial and Dihydrofolate r... 3 0
Epidermal growth factor receptor ligand AGN-PC-078X7L family 4 0
Dihydrofolate reductase inhibitor 2-[[4-[2-(2-amino-4-oxo-1,5,... 2 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 2
Epidermal growth factor receptor ligand (E)-N-[4-(3-bromoanili... 2 1
Epidermal growth factor receptor ligand N-[4-(3-bromoanilino)-... 2 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Alpha-1B adrenergic receptor and Alpha-1A adrenergic receptor ... 2 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 2 0
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 4 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 3
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 1 0
Cathepsin S and Cathepsin K inhibitor AGN-PC-00CD7W family 5 5
Nitric oxide synthase, inducible inhibitor N-[(4-chlorophenyl)... 2 1
Serine/threonine-protein kinase Chk1 inhibitor CHIR-124 family 1 0
Epidermal growth factor receptor ligand AGN-PC-073LJS family 4 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 13
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 5 1
Gonadotropin-releasing hormone receptor ligand SureCN3275214 f... 5 0
Epidermal growth factor receptor ligand (E)-5-[4-(3-bromoanili... 11 0
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Epidermal growth factor receptor ligand (E)-1-[4-(3-bromoanili... 9 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 2 4
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-077RDJ family 15 1
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 7 2
Macrophage colony-stimulating factor 1 receptor ligand N-[3-[(... 5 0
Tyrosine-protein kinase ITK/TSK and Insulin receptor ligand AG... 5 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 2 0
Epidermal growth factor receptor ligand AGN-PC-078X9P family 4 0
P2X purinoceptor 7 inhibitor N-[1-[(Z)-[(cyanoamino)-(quinolin... 3 3
Transient receptor potential cation channel subfamily V member... 3 2
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
Poly [ADP-ribose] polymerase 1 inhibitor Piperazine analogue, ... 4 0
Platelet-derived growth factor receptor beta and Fibroblast gr... 10 0
Melanin-concentrating hormone receptor 1 ligand SureCN3834858 ... 2 1
Collagenase 3 inhibitor MMP-13 Inhibitor family 1 1
Egl nine homolog 1 inhibitor 2-[(1,6-diphenylimidazo[4,5-c]pyr... 1 5
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 1 0
Platelet-derived growth factor receptor beta and Fibroblast gr... 2 1
P2X purinoceptor 7 inhibitor 2-(1-adamantyl)-N-[2-(3-hydroxypr... 2 2
P2Y purinoceptor 12 inhibitor (4S)-4-[(4,6-diphenylpyridine-2-... 1 0
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
Mitogen-activated protein kinase 1 and Aurora kinase A inhibit... 16 3
Melanin-concentrating hormone receptor 1 and Alpha-2A adrenerg... 1 1
Melanin-concentrating hormone receptor 1 and Alpha-2A adrenerg... 1 0
LIM domain kinase 2 inhibitor 3-[[(cyanoamino)-[(2S)-2-methyl-... 6 0
Poly [ADP-ribose] polymerase 1 and Poly [ADP-ribose] polymeras... 4 0
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 1 11
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-07R96X family 7 1
Integrin beta-1 and Integrin alpha-5 inhibitor 2-[(2,6-dimethy... 9 1
Histamine H4 receptor ligand 2-[[6-chloro-2-(4-methylpiperazin... 7 2
Neuropeptide Y receptor type 5 ligand SureCN8149543 family 1 0
Dihydrofolate reductase inhibitor N-(2,4-diamino-5-methylquina... 2 0
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 2
Type-1 angiotensin II receptor ligand 2-[[(5-ethylpyrazolo[1,5... 1 0
Histone deacetylase 1 inhibitor AGN-PC-07ZGOS family 1 0
Tyrosine-protein kinase Lck and Tyrosine-protein kinase Lyn in... 1 0
Ribosomal protein S6 kinase alpha-3 inhibitor AGN-PC-088WRP fa... 1 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 1
Transcription factor AP-1 and Nuclear factor NF-kappa-B p105 s... 2 4
Acetyl-CoA carboxylase 2 and Acetyl-Coenzyme A carboxylase 2 i... 1 0
Melanin-concentrating hormone receptor 1 ligand (E)-3-(4-chlor... 3 7
Melanin-concentrating hormone receptor 1 ligand (E)-3-(4-chlor... 6 0
Corticotropin-releasing factor receptor 2 and Corticotropin-re... 2 1
Cannabinoid receptor 2 ligand AGN-PC-00SRU5 family 2 0
Mitogen-activated protein kinase kinase kinase 5 inhibitor 4-(... 2 0
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 1 0
Histone deacetylase 1 inhibitor N-(2-aminophenyl)-4-[[[4-(cycl... 5 3
Histone deacetylase 1 inhibitor N-(2-aminophenyl)-4-[[(4,6-dim... 1 0
Glycogen synthase kinase-3 beta inhibitor SureCN13987027 family 1 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 2
Vascular endothelial growth factor receptor 2 and Insulin rece... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00244288 CHEMBL362400 Bioactive SureCN13797477
CFAMM00244218 CHEMBL179878 Bioactive SureCN13793330
CFAMM00244194 CHEMBL568162 Bioactive AGN-PC-07CPPW
CFAMM00244279 CHEMBL515093 Bioactive N-(1-methyl-3,4-dihydro-2H-quinolin-7-yl)-4-[(4-phenylquinazolin-2-yl)amino]benzamide
CFAMM00244287 CHEMBL202854 Bioactive AGN-PC-075ZT5
CFAMM00244255 CHEMBL359510 Bioactive SureCN13793501
CFAMM00244286 CHEMBL578166 Bioactive AGN-PC-03Y6VF
CFAMM00244308 CHEMBL181099 Bioactive SureCN13797516
CFAMM00244239 CHEMBL583014 Bioactive AGN-PC-07CPPJ
CFAMM00244269 CHEMBL215981 Bioactive N-[1-[6-[3-[4-(trifluoromethyl)phenyl]propanoylamino]quinolin-2-yl]pyrrolidin-3-yl]benzamide
CFAMM00244198 CHEMBL568208 Bioactive AGN-PC-03Y6XF
CFAMM00244234 DNC004953 Investigative Drug ATC-0175

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26197 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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