CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1604
Family Name Metabotropic glutamate receptor 5 Ligand 3-(3-pyridin-2-yl-pyrazol-1-yl)-benzonitrile Family
No. of Seeds 4 No. of Other Members 24
Family Centroid CFAMM00244703 Functional Category Investigative Drug
Superfamily D(2) dopamine receptor and D(3) dopamine receptor Binder Superfamily 6
Class Class 1034

Cousin Family NamesSeedsMembers
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
Acetylcholinesterase Inhibitor Tacrine Family 12 515
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
D(1B) dopamine receptor Ligand LE-300 Family 65 452
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
PF-4217903 family 14 65
D(4) dopamine receptor Ligand Fauc 113 Family 14 96
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 6 17
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
TGF-beta receptor type-1 Ligand 4-(3-pyridin-2-yl-1h-pyrazol-4... 3 63
TGF-beta receptor type-1 Ligand Naphthyridine Inhibitor Family 3 6
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 19
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Metabotropic glutamate receptor 5 Ligand 3-(1-pyridin-2-yl-1h-... 3 6
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
D(2) dopamine receptor and D(3) dopamine receptor Ligand 1-(4-... 10 48
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 6
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Hepatocyte growth factor receptor Ligand 1-benzyl-1h-pyrrolo[3... 2 16
Kappa-type opioid receptor and Potassium voltage-gated channel... 10 10
Indoleamine 2,3-dioxygenase 1 Inhibitor 4-(1h-1,2,3-triazol-5-... 3 12
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Type-2 angiotensin II receptor Ligand L-158809 Family 22 136
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Metabotropic glutamate receptor 5 Ligand 7-m-tolyl-1,6-naphthy... 4 2
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Xanthine dehydrogenase/oxidase Inhibitor 3,5-di(pyridin-4-yl)-... 6 3
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Protein kinase C alpha type Inhibitor Dequalinium Analogue Family 1 10
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... 3 13
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 14 4
Histamine H3 receptor and Potassium voltage-gated channel subf... 4 33
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Corticotropin-releasing factor receptor 1 ligand 3,7-dimethyl-... 3 4
Smoothened homolog inhibitor AC1P6IWE family 1 0
Survival motor neuron protein and 15-hydroxyprostaglandin dehy... 1 35
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 7 9
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 7
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-00AP1L ... 14 7
Metabotropic glutamate receptor 5 ligand AGN-PC-075GBZ family 2 5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 6
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 10 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 1
Mast/stem cell growth factor receptor Kit and Receptor-type ty... 8 3
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 11 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 1
D(4) dopamine receptor and Alpha-1D adrenergic receptor ligand... 3 3
D(4) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 1
Alpha-1A adrenergic receptor and D(2) dopamine receptor ligand... 1 0
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 3 0
Casein kinase I isoform delta and Casein kinase I isoform epsi... 1 0
Glucocorticoid receptor ligand 1-[(4aS)-6-(4-tert-butylphenyl)... 27 3
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 1-met... 2 0
Glucocorticoid receptor ligand 6-benzyl-1-(4-fluorophenyl)-4a-... 2 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 4-[6-... 3 3
Sigma non-opioid intracellular receptor 1 ligand 1-phenyl-4-(2... 1 0
Progesterone receptor ligand AGN-PC-074LWG family 1 1
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 3 3
Metabotropic glutamate receptor 5 ligand AGN-PC-075GDI family 1 0
Serine/threonine-protein kinase B-raf and Mitogen-activated pr... 16 5
Nociceptin receptor ligand SureCN3543370 family 1 0
Transient receptor potential cation channel subfamily V member... 1 0
TGF-beta receptor type-1 ligand N-(3-cyanophenyl)-2-[3-(6-meth... 4 5
Farnesyl pyrophosphate synthase inhibitor AGN-PC-080IBX family 2 0
Alpha-2A adrenergic receptor and Alpha-2C adrenergic receptor ... 1 4
1,5-dioxidopyrrolo[3,2-c]pyridin-5-ium NP Agn-pc-0639xa Family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00244718 CHEMBL194636 Bioactive AGN-PC-075XU4
CFAMM00244703 DNC004990 Investigative Drug 3-(3-Pyridin-2-yl-pyrazol-1-yl)-benzonitrile
CFAMM00244696 DNC005202 Investigative Drug 3-(5-Pyridin-2-yl-tetrazol-2-yl)-benzonitrile
CFAMM00244699 DNC005199 Investigative Drug 3-(4-Pyridin-2-yl-pyrazol-1-yl)-benzonitrile

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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