CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1613
Family Name TGF-beta receptor type-1 Ligand 4-pyridin-2-yl-5-quinolin-4-yl-thiazol-2-ylamine Family
No. of Seeds 4 No. of Other Members 23
Family Centroid CFAMM00244847 Functional Category Investigative Drug
Superfamily TGF-beta receptor type-1 and C-C chemokine receptor type 4 Binder Superfamily
Class Class 2183

Cousin Family NamesSeedsMembers
Aurora kinase B and Aurora kinase A Inhibitor CYC116 Family 16 135
mRNA of Glucagon receptor Ligand Isis 325568 Family 1 3
5-hydroxytryptamine receptor Ligand Sl65.0472 Family 2 16
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 1 9
Mitogen-activated protein kinase 14 Inhibitor 4-(2-ethyl-4-m-t... 14 41
Metabotropic glutamate receptor 5 Ligand N-[4-(3-pyridylethyny... 2 10
Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibi... 6 64
C-C chemokine receptor type 4 Ligand N-(4-tert-butylthiazol-2-... 3 9
Cyclin-dependent kinase 5 Inhibitor 1-phenyl-3-(2-(pyridin-4-y... 3 53
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 4 23
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
Histamine H3 receptor Ligand 2-(1,4'-bipiperidin-1'-yl)thiazol... 2 23
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-264... 6 32
Amine oxidase [flavin-containing] B Inhibitor 2-(2-cyclohexyli... 6 44
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
RAC-alpha serine/threonine-protein kinase and Cyclin-dependent... 2 7
Histamine H3 receptor and Potassium voltage-gated channel subf... 6 20
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(4-acet... 4 12
Tyrosine-protein kinase JAK2 and Potassium voltage-gated chann... 1 0
Mitogen-activated protein kinase 14 inhibitor 4-[4-(4-fluoroph... 2 0
Neuropeptide Y receptor type 5 ligand N-[[(1S,5R)-3-(1-phenyle... 5 1
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07ZXHN fa... 2 4
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 1 inhibi... 2 0
Mitogen-activated protein kinase 14 and LIM domain kinase 1 in... 4 19
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 8
DNA-(apurinic or apyrimidinic site) lyase and Neuropeptide S r... 1 4
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 10
Adenosine kinase inhibitor SureCN8183719 family 2 3
Amine oxidase [flavin-containing] B inhibitor 4-(4-fluoropheny... 3 4
Cell division cycle 7-related protein kinase inhibitor AGN-PC-... 6 6
Platelet-activating factor receptor ligand Foropafant family 2 0
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 5 27
Metabotropic glutamate receptor 4 and Potassium voltage-gated ... 2 15
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 7 21
Mitogen-activated protein kinase 14 inhibitor N-[4-[2-ETHYL-4-... 4 5
5-hydroxytryptamine receptor 6 ligand 5-[3-(1-benzylpyrrolidin... 1 0
Adenosine receptor A2b and Adenosine receptor A3 ligand 3-[5-(... 4 2
Serine/threonine-protein kinase Chk1 inhibitor 3-[5-[2-[(4-mor... 2 3
Serine/threonine-protein kinase Chk1 inhibitor 5-[5-(1-methylp... 3 2
Orexin receptor type 2 and Orexin receptor type 1 ligand (2-me... 3 1
D(3) dopamine receptor and D(2) dopamine receptor ligand 6-N-[... 3 0
Vascular endothelial growth factor receptor 2 ligand N-(1,3-Th... 4 4
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(1,4-di... 3 3
Mitogen-activated protein kinase 14 inhibitor 303163-37-3 family 1 2
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 4 5
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 4 1
Transient receptor potential cation channel subfamily V member... 1 0
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 2 4
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 5 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00244832 DNC005021 Investigative Drug 4-Pyridin-3-yl-5-quinolin-4-yl-thiazol-2-ylamine
CFAMM00244847 DNC005020 Investigative Drug 4-Pyridin-2-yl-5-quinolin-4-yl-thiazol-2-ylamine
CFAMM00244827 DNC005206 Investigative Drug 4-Pyridin-2-yl-5-quinolin-2-yl-thiazol-2-ylamine
CFAMM00244826 DNC005205 Investigative Drug 5''-Quinolin-4-yl-[2,4'']bithiazolyl-2''-ylamine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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