CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1625
Family Name Oestrogen receptor and Estrogen receptor beta Ligand 7-chloro-2-(4-hydroxy-phenyl)-benzofuran-5-ol Family
No. of Seeds 2 No. of Other Members 27
Family Centroid CFAMM00244965 Functional Category Investigative Drug with Natural Product
Superfamily Estrogen receptor beta and Oestrogen receptor Binder Superfamily
Class Class 1784

Cousin Family NamesSeedsMembers
Retinoic acid receptor Ligand naphthoic acid derivative Adapal... 2 264
Cyclooxygenase Inhibitor Fenoprofen Family 4 1077
Cyclooxygenase inhibitor salicylate derivative Aspirin family 3 234
Vitamin K epoxide reductase complex subunit 1 Inhibitor Warfar... 9 508
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor Mycophenola... 4 353
Heat shock protein 90, putative Inhibitor Cromoglicate Family 14 2827
DNA Binder Methoxsalen Family 10 1638
Vitamin K-dependent gamma-carboxylase Inhibitor Anisindione Fa... 3 243
D-alanyl-D-alanine carboxypeptidase Inhibitor B-lactams Family 59 1364
Aldehyde oxidase Inhibitor Isovanillin Family 6 429
Hidrosmin family 14 61
Ipriflavone family 62 2480
Rotenone family 16 107
Agrimophol family 10 22
Leukotriene B4 receptor 1 Ligand LY293111 Family 24 79
Sphingosine kinase 2 Inhibitor Phenoxodiol Family 24 682
Multidrug resistance-associated protein 1 Inhibitor Benzbromar... 2 16
Multidrug resistance protein Inhibitor Curcumin I Family 19 278
Eprotirome family 11 50
Interleukin-1 beta Inhibitor Diacerein Family 3 77
Endothelin-1 receptor Ligand PD156707 Family 41 211
Estrogen receptor beta Ligand 2-(4-hydroxy-phenyl)benzofuran-5... 5 82
Phospholipase A2 Inhibitor P-anisic Acid Family 2 178
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 2,5-... 2 96
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor (2,5... 1 9
Steryl-sulfatase Inhibitor Sulfamic Acid 2-nonyl-4-oxo-4h-chro... 4 68
Aromatase and DNA-dependent protein kinase catalytic subunit I... 6 19
Phospholipase A2 Inhibitor 3,9-dihydroxy-2,10-diprenylpterocap... 9 25
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 56
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 9 81
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 3
4-aminobutyrate aminotransferase, mitochondrial and Succinate-... 4 22
Oestrogen receptor and Estrogen receptor beta Ligand 3,8-dihyd... 20 57
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Ellagi... 1 11
Platelet-derived growth factor receptor beta Ligand Bis(5-meth... 5 220
Tyrosine-protein phosphatase non-receptor type 1 Ligand Licoag... 9 32
Cytosolic phospholipase A2 Inhibitor [6,3''']biflavone Family 5 5
MO15-related protein kinase Pfmrk Inhibitor WR-289012 Family 2 17
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 3-ben... 4 74
Cannabinoid receptor 2 Ligand 2-(2-methoxybenzyl)-3h-benzo[f]c... 6 32
Protein kinase C gamma type and Protein kinase C alpha type In... 2 1
Amine oxidase [flavin-containing] B Inhibitor (s)(+)-7-fluoro-... 11 11
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 2-(3-c... 5 72
Epidermal growth factor receptor Ligand 3-(3-chloro-phenyl)-5,... 10 64
Protein farnesyltransferase subunit beta Inhibitor Cylindrol A... 3 43
Prostaglandin G/H synthase 2 Inhibitor 3,4-dibenzyloxy-2'-hydr... 7 40
CGMP-dependent protein kinase Inhibitor Tenellone A Family 1 7
Prostaglandin G/H synthase 2 Inhibitor Neolignan 9-nor-7,8-deh... 1 7
Creatine kinase Inhibitor 5-(4'-benzoylbiphenyl-4-yl)-2-furoic... 2 66
Liver carboxylesterase 1 Inhibitor 2-methoxy-3,4-methylenediox... 4 26
ELAV-like protein 1 and Myosin light chain kinase, smooth musc... 1 32
Retinoic acid receptor RXR-alpha and Peroxisome proliferator-a... 3 17
Carbonic anhydrase 2 inhibitor (2-sulfamoyl-1-benzofuran-5-yl)... 4 2
Thromboxane A2 receptor and Prostacyclin receptor ligand AGN-P... 2 30
Arachidonate 5-lipoxygenase inhibitor 7-[[3-fluoro-5-(3-hydrox... 2 10
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 2 7
Estrogen receptor beta and Estrogen receptor ligand 4-[(7E)-7-... 1 1
Estrogen receptor beta and Estrogen receptor ligand SureCN4017... 3 5
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 7 13
Histone deacetylase 2 and Histone deacetylase 8 inhibitor AC1L... 2 2
Estrogen receptor beta and Estrogen receptor ligand AGN-PC-075... 1 0
Transthyretin inhibitor AGN-PC-046XQV family 1 6
Arachidonate 5-lipoxygenase inhibitor SureCN9740792 family 2 6
Sodium-dependent serotonin transporter and Sodium-dependent do... 3 78
Tyrosine-protein phosphatase non-receptor type 1 ligand 4-[4-[... 6 2
Glycogen synthase kinase-3 beta inhibitor 5-(5-methylfuran-2-y... 7 6
Glycogen synthase kinase-3 beta inhibitor AGN-PC-07CO97 family 1 1
Thyroid hormone receptor beta and Thyroid hormone receptor alp... 1 1
Cytochrome P450 3A4 inhibitor 4-[(2E)-6-[(E)-3-hydroxy-2,6-dim... 3 2
Cannabinoid receptor 1 and Cytochrome P450 3A4 ligand LY320135... 1 0
Prelamin-A/C and Inositol monophosphatase 1 inhibitor MLS00053... 1 1
Naphthofurans Metabolite Pyrocurzerenone Family 1 9
5,6-dihydro-4H-furo[2',3':3,4]cyclohepta[1,2-b][1]benzofuran N... 3 0
NP 2,2,11,12-tetramethyl-3,4,8,9-tetrahydro-2h-cyclopenta[c]fu... 3 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00244984 CHEMBL183152 Bioactive AGN-PC-03MCI3
CFAMM00244965 DNC005053 Investigative Drug 7-Chloro-2-(4-hydroxy-phenyl)-benzofuran-5-ol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27054 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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