CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1626
Family Name Melanin-concentrating hormone receptor 1 Ligand 8-sec-butoxy-quinolin-2-ylamine Family
No. of Seeds 30 No. of Other Members 39
Family Centroid CFAMM00245041 Functional Category Investigative Drug
Superfamily 5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine receptor 1A Binder Superfamily
Class Class 866

Cousin Family NamesSeedsMembers
Phospholipase A2 Inhibitor Quinacrine Family 13 95
Peptide deformylase, mitochondrial Inhibitor Trimethoprim Family 67 482
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Arachidonate 5-lipoxygenase-activating protein Inhibitor DG031... 3 206
Corticotropin-releasing factor receptor 1 Ligand Cp-316,311 Fa... 5 74
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
SB1518 family 7 103
Peptide deformylase, mitochondrial Inhibitor 5-(4-methoxypheno... 5 61
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Melanin-concentrating hormone receptor 1 Ligand Gnf-pf-2322 Fa... 3 95
D(2) dopamine receptor Ligand SLV-314 Family 19 69
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Indoleamine 2,3-dioxygenase 1 Inhibitor 5-aminoquinolin-8-ol F... 3 16
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-(2-m... 2 12
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Sodium channel protein type 5 subunit alpha Ligand Enecadin Fa... 1 11
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(2-methyl... 7 27
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 5 45
Survival motor neuron protein inhibitor CHEMBL1307497 family 1 2
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 14
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Methionine--tRNA ligase inhibitor 2-[3-[(2-ethoxy-5-iodo-3-met... 9 32
Methionine--tRNA ligase inhibitor SureCN7818124 family 1 9
Prostaglandin D2 receptor ligand 2-[3-[2-methoxy-6-[2-(4-metho... 4 12
Butyrylcholinesterase and Acetylcholinesterase inhibitor AGN-P... 9 24
Adenosine receptor A3 ligand AGN-PC-08WSLM family 5 22
Corticotropin-releasing factor receptor 1 ligand 6-ethyl-3-met... 6 10
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075FPC ... 6 1
Melanin-concentrating hormone receptor 1 ligand N-[3-(2-aminoq... 4 1
Cysteinyl leukotriene receptor 1 ligand SureCN7008285 family 12 97
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075FSU ... 1 1
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 4 4
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 3 5
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 2
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-1-N-(4... 3 9
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[[4... 7 4
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[[2... 4 4
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 2 6
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 3 10
Dihydrofolate reductase inhibitor AGN-PC-001U7R family 3 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 23 5
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 3 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 5 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 4 3
Nischarin inhibitor SureCN7810370 family 1 0
Nitric oxide synthase, brain and Nitric oxide synthase, induci... 1 8
Potassium-transporting ATPase subunit beta and Potassium-trans... 2 0


External ID

Functional Category

Molecule Name

CFAMM00245075 DNC005097 Investigative Drug 8-(2-Methyl-cyclohexyloxy)-quinolin-2-ylamine
CFAMM00245068 DNC005099 Investigative Drug 8-(3-Methyl-cyclohexyloxy)-quinolin-2-ylamine
CFAMM00245082 DNC005074 Investigative Drug 8-Cyclobutylmethoxy-quinolin-2-ylamine
CFAMM00245039 DNC005081 Investigative Drug 8-(3,3-Dimethyl-butoxy)-quinolin-2-ylamine
CFAMM00245074 DNC005096 Investigative Drug 8-(3-Methyl-cyclopentyloxy)-quinolin-2-ylamine
CFAMM00245088 DNC005079 Investigative Drug 8-Cyclopentylmethoxy-quinolin-2-ylamine
CFAMM00245067 DNC005098 Investigative Drug 8-(2-Ethoxy-1-methyl-ethoxy)-quinolin-2-ylamine
CFAMM00245081 DNC005077 Investigative Drug 8-(2-Methyl-butoxy)-quinolin-2-ylamine
CFAMM00245016 DNC005101 Investigative Drug 8-Cycloheptyloxy-quinolin-2-ylamine
CFAMM00245038 DNC005082 Investigative Drug 8-(3,3,3-trifluoropropoxy)quinolin-2-amine
CFAMM00245055 DNC011059 Investigative Drug GNF-PF-2700
CFAMM00245073 DNC005095 Investigative Drug 8-Cyclohexyloxy-quinolin-2-ylamine
CFAMM00245087 DNC005078 Investigative Drug 8-(3-Methyl-butoxy)-quinolin-2-ylamine
CFAMM00245080 DNC005076 Investigative Drug 8-Pentyloxy-quinolin-2-ylamine
CFAMM00245015 DNC005100 Investigative Drug 8-(4-Methyl-cyclohexyloxy)-quinolin-2-ylamine
CFAMM00245037 DNC005087 Investigative Drug 8-(3-Methoxy-3-methyl-butoxy)-quinolin-2-ylamine
CFAMM00245072 DNC005094 Investigative Drug 8-(2-Methoxy-1-methyl-ethoxy)-quinolin-2-ylamine
CFAMM00245014 DNC005103 Investigative Drug 8-Methoxy-quinolin-2-ylamine
CFAMM00245071 DNC005093 Investigative Drug 8-(1-Ethyl-propoxy)-quinolin-2-ylamine
CFAMM00245042 DNC005088 Investigative Drug 8-Isopropoxy-quinolin-2-ylamine
CFAMM00245063 DNC005066 Investigative Drug A-224940
CFAMM00245013 DNC005102 Investigative Drug 8-(2-Ethyl-1-methyl-butoxy)-quinolin-2-ylamine
CFAMM00245084 DNC005073 Investigative Drug 8-Butoxy-quinolin-2-ylamine
CFAMM00245070 DNC005092 Investigative Drug 8-(1,2-Dimethyl-propoxy)-quinolin-2-ylamine
CFAMM00245041 DNC005089 Investigative Drug 8-sec-Butoxy-quinolin-2-ylamine
CFAMM00245062 DNC005065 Investigative Drug 8-(1,3,3-Trimethyl-butoxy)-quinolin-2-ylamine
CFAMM00245012 DNC005104 Investigative Drug 8-Propoxy-quinolin-2-ylamine
CFAMM00245069 DNC005091 Investigative Drug 8-(1-Methyl-butoxy)-quinolin-2-ylamine
CFAMM00245083 DNC005075 Investigative Drug 8-(2-Cyclopropyl-ethoxy)-quinolin-2-ylamine
CFAMM00245040 DNC005080 Investigative Drug 8-Hexyloxy-quinolin-2-ylamine

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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