CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1627
Family Name Vascular endothelial growth factor receptor 2 Ligand Isoindolinone Urea Derivative Family
No. of Seeds 11 No. of Other Members 36
Family Centroid CFAMM00245126 Functional Category Investigative Drug
Superfamily Vascular endothelial growth factor receptor 2 Ligand Isoindolinone Urea Derivative Superfamily
Class Class 247

Cousin Family NamesSeedsMembers
High affinity nerve growth factor receptor Ligand Lestaurtinib... 6 126
Fibroblast growth factor receptor 1 and Aurora kinase B Inhibi... 4 51
B-lymphocyte antigen CD20 Inhibitor Rituxan Immunology Family 10 17
Vascular endothelial growth factor receptor 1 and Angiopoietin... 29 127
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
NF-kappa-B and Protein kinase C zeta type Inhibitor Go6976 Family 9 71
DNA topoisomerase 1 Inhibitor KT6006 Family 3 53
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Serine/threonine-protein kinase Chk1 and Wee1-like protein kin... 2 101
High affinity nerve growth factor receptor and Mitogen-activat... 2 7
Kinesin-like protein KIF11 Inhibitor Methyl 7-tert-butyl-9h-ca... 2 9
Vascular endothelial growth factor receptor 2 and Angiopoietin... 4 1
Sodium-dependent serotonin transporter and D(2) dopamine recep... 13 2
Cysteinyl leukotriene receptor 1 ligand AGN-PC-075KCE family 5 33
Thyroid hormone receptor beta and Microtubule-associated prote... 1 8
Protein kinase C alpha type and Protein kinase C delta type in... 4 37
Cannabinoid receptor 1 ligand 5-cyano-N-(3-hydroxy-2,2-dimethy... 4 2
Serine/threonine-protein kinase mTOR inhibitor AGN-PC-093LHN f... 3 2
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor dihydro-benz... 3 5
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 3
Rho-associated protein kinase 2 and Rho-associated protein kin... 2 6
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... 5 11
Poly [ADP-ribose] polymerase 1 inhibitor CHEMBL1935258 family 7 2
Angiopoietin-1 receptor and Vascular endothelial growth factor... 7 2
Vascular endothelial growth factor receptor 2 and Angiopoietin... 4 0
Vascular endothelial growth factor receptor 2 and Angiopoietin... 14 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 9 0
Tyrosine-protein kinase JAK3 inhibitor CHEMBL234066 family 1 2
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
High affinity nerve growth factor receptor ligand CHEMBL254555... 2 2
Wee1-like protein kinase and Serine/threonine-protein kinase C... 3 51
Serine/threonine-protein kinase Chk1 and Wee1-like protein kin... 3 12
Wee1-like protein kinase and Serine/threonine-protein kinase C... 8 0
Protein kinase C alpha type and Protein kinase C delta type in... 2 0
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 6 8
Angiopoietin-1 receptor and Vascular endothelial growth factor... 1 0
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 2 0
Peroxisome proliferator-activated receptor gamma ligand AGN-PC... 4 4
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00245129 CHEMBL1084062 Bioactive AGN-PC-07ZG4M
CFAMM00245128 CHEMBL1084061 Bioactive AGN-PC-07ZG4L
CFAMM00245113 CHEMBL150894 Bioactive SureCN2493544
CFAMM00245132 CHEMBL424323 Bioactive SureCN13140125
CFAMM00245126 DNC005067 Investigative Drug Isoindolinone Urea derivative

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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