CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1628
Family Name 5-hydroxytryptamine receptor 1D and Alpha-1A adrenergic receptor Ligand 2-(4-tert-butyl-phenyl)-4,5-dihydro-1h-imidazole Family
No. of Seeds 3 No. of Other Members 22
Family Centroid CFAMM00245162 Functional Category Investigative Drug
Superfamily Alpha adrenergic receptor Ligand Tolazoline Superfamily
Class Class 45

Cousin Family NamesSeedsMembers
AMP-activated protein kinase Inhibitor Phenformin Family 5 14
Alpha adrenergic receptor Ligand Tolazoline Family 7 51
Alpha-2A adrenergic receptor Ligand Brl 44408 Family 1 0
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
Nitric oxide synthase, brain Inhibitor 1-(benzhydrylamino)etha... 1 4
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 4 6
Glutamate receptor ionotropic, NMDA 2B ligand N'-[(3,5-dimethy... 1 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 9 12
Neuropeptide Y receptor type 5 ligand SureCN4473192 family 1 2
Neuropeptide Y receptor type 5 ligand SureCN4468114 family 1 0
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 1 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 1 2
Potassium voltage-gated channel subfamily H member 2 ligand Su... 1 0
Retinal dehydrogenase 1 and Nuclear receptor ROR-gamma ligand ... 2 1
11,13-dihydroisoindolo[2,1-b][2,4]benzodiazepin-12-ium-6-amine... 1 0


External ID

Functional Category

Molecule Name

CFAMM00245143 CHEMBL180397 Bioactive (4R,5S)-2-(2-methyl-2-phenylpropyl)-4,5-diphenyl-4,5-dihydro-1H-imidazole
CFAMM00245164 DNC008783 Investigative Drug 2,4,4-triphenylimidazoline
CFAMM00245162 DNC005068 Investigative Drug 2-(4-tert-Butyl-phenyl)-4,5-dihydro-1H-imidazole

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

Last update by



76075 visits since 2014 .........


Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

All rights reserved.

Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links


Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543