CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID163
Family Name Alpha-2C adrenergic receptor Ligand ARC239 Family
No. of Seeds 15 No. of Other Members 23
Family Centroid CFAMM00182664 Functional Category Investigative Drug
Superfamily Alpha-2C adrenergic receptor and 5-hydroxytryptamine receptor 1A Binder Superfamily
Class Class 1441

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Acetylcholinesterase Inhibitor Donepezil Family 23 242
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 3 27
D(2) dopamine receptor Ligand Pardoprunox Family 4 81
D(2) dopamine receptor Ligand Rotigotine Patch Family 1 2
Tumor necrosis factor Inhibitor Tgaac-94 Family 6 107
Cinitapride family 4 22
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Muscarinic acetylcholine receptor M1 Ligand AC-260584 Family 4 36
Neuropeptide Y receptor type 1 Ligand BMS-193885 Family 3 11
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Alpha-1 adrenergic receptor Ligand DC-015 Family 8 25
5-hydroxytryptamine receptor 1A Ligand Du 125530 Family 2 0
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand JT... 14 4
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
5-hydroxytryptamine receptor 6 Ligand Sb 258585 Family 11 121
Tubulin Inhibitor WR85915 Family 3 15
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 7 5
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 7 23
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 18 12
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Potassium ... 1 15
Cruzipain Inhibitor 1-(3-methoxy-benzyl)-5-methyl-1h-indole-2,... 2 11
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 4-(2... 4 31
Oxytocin receptor and Vasopressin V1a receptor Ligand L-371257... 8 92
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 6 23
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 131
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand RWJ-68141 Family 5 4
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Alpha-1A adrenergic receptor Ligand Naftopidil Family 15 119
Peroxisome proliferator-activated receptor gamma and Peroxisom... 1 31
Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family 4 23
Oxysterols receptor LXR-alpha Ligand N-{4-[2-(4-methoxyphenyl)... 3 16
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Liver carboxylesterase 1 Inhibitor 5-(trifluoromethoxy)-1h-ind... 3 12
Amyloid beta A4 protein Inhibitor 6-iodo-4'-methylaminoflavone... 3 33
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Alpha-1A adrenergic receptor and D(2) dopamine receptor Ligand... 5 49
Histone deacetylase 2 Inhibitor N-(4-amino-3'-methoxybiphenyl-... 3 49
Leukotriene A-4 hydrolase Inhibitor N5-[4-(2-oxo-3-phenylpropo... 1 61
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Macrophage migration inhibitory factor Inhibitor 3-benzyl-5-me... 10 42
Macrophage migration inhibitory factor Inhibitor Benzofuran-2-... 5 67
Sodium channel protein type 10 subunit alpha and Sodium channe... 2 13
Amine oxidase [flavin-containing] B Inhibitor N-methyl-n-pheny... 6 25
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-(3-morpholinop... 24 102
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 8 41
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-237... 21 56
Leukotriene A-4 hydrolase Inhibitor 1-[4-(4-iodophenoxy)phenyl... 5 18
Urotensin-2 receptor Ligand JNJ-28318706 Family 4 227
Proto-oncogene tyrosine-protein kinase receptor Ret Ligand (z)... 1 60
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 16
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 28 24
D(2) dopamine receptor Ligand Epidepride Family 31 66
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 8 39
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
Liver carboxylesterase 1 Inhibitor SCH-48375 Family 2 28
Tubulin beta chain Inhibitor Gnf-pf-117 Family 2 16
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 1 7
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
3-oxo-5-alpha-steroid 4-dehydrogenase 2 and 3-oxo-5-alpha-ster... 3 5
Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]... 11 10
D(2) dopamine receptor ligand 7-[4-[4-(2-ethoxyphenyl)piperazi... 12 14
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEH3 family 3 16
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 14 12
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 5 13
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[(3... 2 11
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 9 22
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide, 8... 4 15
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(4-... 3 5
Alpha-2A adrenergic receptor and 5-hydroxytryptamine receptor ... 7 10
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 3 2
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 2 0
C-C chemokine receptor type 3 ligand SureCN6705515 family 2 16
Alpha-1A adrenergic receptor and 5-hydroxytryptamine receptor ... 3 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 49 8
Kappa-type opioid receptor ligand AGN-PC-09M90I family 2 3
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 4
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 12 10
D(3) dopamine receptor and D(1A) dopamine receptor ligand N-[(... 6 14
Microsomal triglyceride transfer protein large subunit inhibit... 4 5
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 8 0
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-N... 2 2
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 4 8
Coagulation factor X and Trypsin-1 inhibitor AGN-PC-01ZLS4 family 2 8
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2C lig... 2 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 1
Multidrug resistance protein 1 inhibitor 1-[2-[(2R)-3-[4-(2,3-... 2 41
Nuclear receptor ROR-gamma and Menin ligand CHEMBL1432265 family 1 18
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 2
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 4 4
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 3 8
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 3
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 7 4
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 5 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 9 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 1
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 7 9
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 11 9
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 6 16
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 7
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 3 1
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 4 2
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
C5a anaphylatoxin chemotactic receptor 1 ligand N-[(4-dimethyl... 1 4
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 3 2
Prostaglandin E2 receptor EP4 subtype ligand AGN-PC-09QMLE family 5 0
DNA-dependent protein kinase catalytic subunit and Phosphatidy... 1 6
3-oxo-5-alpha-steroid 4-dehydrogenase 1 inhibitor N-[(1S,5aR,9... 2 2
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 11 4
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 2
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 4 1
Histamine H3 receptor ligand SureCN2785624 family 2 0
Androgen receptor ligand (2R)-2-ethyl-1-(2,2,2-trifluoroethyl)... 32 6
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand CHEMB... 13 20
Prostaglandin D2 receptor and Prostacyclin receptor ligand 2-[... 15 5
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 1 0
Transient receptor potential cation channel subfamily V member... 1 0
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 3
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 2 0
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Cathepsin L1 and Cathepsin S inhibitor arylaminoethyl amide, 5... 4 5
Growth hormone secretagogue receptor type 1 ligand (2R)-N-(1-b... 11 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 1
Microsomal triglyceride transfer protein large subunit inhibit... 3 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
Motilin receptor ligand SureCN14564469 family 1 6
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 3
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand CHEMB... 6 3
Cathepsin K inhibitor (1R,2R)-N-(cyanomethyl)-2-[4-(3-methoxyp... 2 1
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 2 1
Integrin beta-3 and Integrin alpha-2 inhibitor 3-(4-methoxyphe... 4 6
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 1 0
Bifunctional epoxide hydrolase 2 inhibitor 3-[4-[[4-(trifluoro... 5 22
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 6 11
Sodium-dependent serotonin transporter and D(2) dopamine recep... 8 6
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 5 8
5-hydroxytryptamine receptor 7 ligand 1-(2-methoxyphenyl)-4-[2... 6 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 10
Poly [ADP-ribose] polymerase 1 inhibitor 3-chloro-N-cyclopropy... 1 2
Poly [ADP-ribose] polymerase 1 inhibitor N-ethyl-4-[4-[(8-meth... 1 0
E3 ubiquitin-protein ligase XIAP and Cytochrome P450 3A4 inhib... 1 2
Bifunctional epoxide hydrolase 2 inhibitor 8-(2,6-difluorobenz... 4 1
Bifunctional epoxide hydrolase 2 inhibitor 8-(2-fluoro-5-hydro... 2 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 1 2
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 1 5
Glutamate receptor ionotropic, NMDA 2B and Potassium voltage-g... 2 1
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 7 1
Kinesin-like protein KIF11 and Potassium voltage-gated channel... 10 2
Kinesin-like protein KIF11 and Potassium voltage-gated channel... 3 1
Progesterone receptor ligand CHEMBL252850 family 2 0
5-hydroxytryptamine receptor 1A ligand SureCN10513645 family 9 1
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
Delta-type opioid receptor and Kappa-type opioid receptor liga... 5 0
D(3) dopamine receptor and D(4) dopamine receptor ligand SureC... 3 19
5-hydroxytryptamine receptor 1A ligand 3-hydroxy-6-iodo-2-[2-[... 2 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 2
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 7 10
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 4 4
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 12 4
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
Mu-type opioid receptor ligand AGN-PC-00NCMO family 3 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 2
Urotensin-2 receptor ligand SureCN4431593 family 1 7
Histamine H3 receptor ligand AGN-PC-00AE5Q family 13 13
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 9
Histamine H3 receptor and Potassium voltage-gated channel subf... 28 30
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 5 5
Leukotriene A-4 hydrolase inhibitor SureCN5313952 family 4 1
Growth hormone secretagogue receptor type 1 ligand N-[4-[(2S)-... 1 0
Lanosterol synthase inhibitor AGN-PC-07BZTC family 1 3
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 12
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 1 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 1 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 1
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 2 9
Mitogen-activated protein kinase 14 inhibitor AGN-PC-00A4QT fa... 2 0
Mitogen-activated protein kinase 14 inhibitor ITX 5061 free ba... 2 3
Calcitonin gene-related peptide type 1 receptor ligand 2-(4-me... 4 4
Mineralocorticoid receptor and Glucocorticoid receptor ligand ... 2 0
Gonadotropin-releasing hormone receptor ligand CHEMBL260816 fa... 1 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 2 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 1 0
Cyclin-dependent kinase 4 inhibitor SureCN13343915 family 2 2
Cyclin-dependent kinase 4 inhibitor SureCN3563106 family 1 1
Sterol O-acyltransferase 1 inhibitor SureCN5812305 family 1 0
Thioredoxin glutathione reductase and Microtubule-associated p... 1 2
Huntingtin and Retinal dehydrogenase 1 inhibitor CHEMBL1467512... 1 0
Multidrug resistance protein 1 inhibitor (1R)-2-[4-(2-methoxyp... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00182646 CHEMBL42711 Bioactive 5-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]phenanthridin-6-one
CFAMM00182664 DNC000251 Investigative Drug ARC239
CFAMM00182668 DNC000252 Investigative Drug ARC-239

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24317 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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