CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1679
Family Name Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand WIN-55212-2 Family
No. of Seeds 12 No. of Other Members 52
Family Centroid CFAMM00246044 Functional Category Investigative Drug
Superfamily Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand WIN-55212-2 Superfamily
Class Class 297

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Phospholipase A2, membrane associated Inhibitor Varespladib Fa... 37 190
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
Indeglitazar family 3 39
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
5-hydroxytryptamine receptor 1A Ligand Sun N4057 Family 2 86
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(furan-3-... 3 44
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
Cytochrome P450 11B1, mitochondrial Inhibitor 5-(6-methoxynaph... 7 4
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 28 24
Prostaglandin G/H synthase 2 Inhibitor L-761000 Family 8 44
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 1 4
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Acetylcholinesterase Inhibitor Lysicamine Family 2 8
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 11
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 10 4
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 4 20
Translocator protein inhibitor SureCN13502542 family 20 2
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Phospholipase A2 inhibitor SureCN7046992 family 2 3
Acetylcholinesterase and Muscarinic acetylcholine receptor M2 ... 2 7
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 8 32
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 8 21
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 3
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Vascular endothelial growth factor receptor 2 and Aurora kinas... 3 3
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 4 14
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Potassium voltage-gated channel subfamily H member 2 and Kappa... 5 33
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Acetylcholinesterase and Cholinesterase inhibitor (2Z)-5-metho... 4 23
B2 bradykinin receptor ligand SureCN6640854 family 7 4
D(2) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 6 22
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... 2 2
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 11
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 7
Histamine H3 receptor ligand SureCN2784306 family 5 3
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 4 0
5-hydroxytryptamine receptor 6 ligand SureCN5498885 family 5 4
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 5
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 11 11
Serine/threonine-protein kinase B-raf inhibitor furan-based co... 6 3
Prostaglandin D2 receptor and Prostacyclin receptor ligand 2-[... 15 2
Renin inhibitor [2-(3-fluoro-2,6-dimethylphenoxy)-1-phenylpyrr... 5 12
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [5-(o... 4 4
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
Sodium-dependent serotonin transporter inhibitor AGN-PC-075G9A... 3 2
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor 3-... 4 8
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 19 10
D(2) dopamine receptor and D(3) dopamine receptor ligand N-[3-... 7 3
Glycogen synthase kinase-3 beta inhibitor CHEMBL1940990 family 3 3
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
Integrase inhibitor (Z)-4-[1-[(4-fluorophenyl)methyl]-5-methox... 1 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 8 4
Serine/threonine-protein kinase pim-2 and cGMP-dependent prote... 8 1
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Peroxisome proliferator-activated receptor alpha and Peroxisom... 1 4
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[(1... 2 0
Cytosolic phospholipase A2 inhibitor AGN-PC-00BH8R family 6 13
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 3 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 12 0
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Sonic hedgehog protein inhibitor 3-methoxy-1-methyl-4-oxo-5-ph... 5 3
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 3 2
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand 7-met... 3 2
Substance-P receptor ligand AGN-PC-01VLKE family 9 11
Casein kinase I isoform gamma-2 and Casein kinase I isoform de... 5 2
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 1 1
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... 1 3
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 4 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand SureC... 1 3
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 3
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 7 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 7-met... 2 1
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 2 1
Cannabinoid receptor 1 ligand (4-hydroxynaphthalen-1-yl)-[1-(2... 2 0
Vasopressin V2 receptor ligand SureCN4400636 family 1 0
B2 bradykinin receptor ligand (E)-N-[2-[N-methyl-3-[(2-methylq... 2 0
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
Macrophage colony-stimulating factor 1 receptor ligand 4-(2,3-... 12 7
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 1 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 0
Ras guanyl-releasing protein 3 and Protein kinase C alpha type... 2 6
B2 bradykinin receptor ligand 1-N,3-N-dimethyl-4-[methyl-[2-[[... 4 1
Serine/threonine-protein kinase Chk1 inhibitor 9-(1-methylpyrr... 1 1
B2 bradykinin receptor and Cytochrome P450 3A4 ligand SureCN15... 4 0
Platelet-activating factor receptor ligand (7-phenylmethoxy-1H... 1 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1
DNA-dependent protein kinase catalytic subunit inhibitor 2-mor... 1 4
P2Y purinoceptor 1 inhibitor N-[2-(2-tert-butylphenoxy)pyridin... 1 0
5-hydroxytryptamine receptor 2C ligand SureCN4230099 family 1 1
Aldose reductase inhibitor [1-(3,5-difluoro-4-hydroxyphenyl)py... 3 2
1-[1-(furan-2-ylmethyl)-5-hydroxy-2-methylindol-3-yl]ethanone ... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00246065 CHEMBL27388 Bioactive AGN-PC-003FAG
CFAMM00246084 CHEMBL78415 Bioactive SureCN7782596
CFAMM00246064 CHEMBL1209644 Bioactive CHEMBL1209644
CFAMM00246096 CHEMBL2381801 Bioactive CHEMBL2381801
CFAMM00246076 CHEMBL286248 Bioactive AGN-PC-003FAD
CFAMM00246101 CHEMBL1209710 Bioactive CHEMBL1209710
CFAMM00246053 CHEMBL2380420 Bioactive (1-butyl-7-methoxyindol-3-yl)-naphthalen-1-ylmethanone
CFAMM00246100 CHEMBL1209807 Bioactive CHEMBL1209807
CFAMM00246060 CHEMBL1222317 Bioactive 131543-23-2
CFAMM00246086 CHEMBL1209573 Bioactive CHEMBL1209573
CFAMM00246038 CHEMBL1209645 Bioactive CHEMBL1209645
CFAMM00246044 DNC005282 Investigative Drug WIN-55212-2

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26839 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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