CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1684
Family Name Adenosine receptor A1 and Adenosine receptor A3 Ligand 2-(4-methoxyphenyl)-6-phenyl-9h-purine Family
No. of Seeds 3 No. of Other Members 23
Family Centroid CFAMM00246191 Functional Category Investigative Drug with Natural Product
Superfamily Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Inhibitor TG100-115 Superfamily
Class Class 931

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Astemizole Family 7 240
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Histamine H1 receptor Ligand Mepyramine Family 5 65
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Cyclin-dependent kinase 2 Inhibitor Seliciclib Family 29 292
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
Receptor tyrosine-protein kinase erbB-2 Inhibitor TAK-285 Family 16 124
Corticotropin-releasing factor receptor 1 Ligand GW876008 Family 3 30
SB1518 family 7 103
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
Ibrutinib family 2 27
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Tyrosine kinase Inhibitor PKI166 Family 17 198
Histamine H3 receptor Ligand 4-(3-phenoxy-propyl)-1h-imidazole... 26 142
5-hydroxytryptamine receptor 3A and Alpha-2A adrenergic recept... 31 24
Heat shock protein HSP 90-alpha Inhibitor 8-benzo[1,3]dioxol-,... 5 83
Cyclin-dependent kinase 2 Inhibitor 6-cyclohexylmethyloxy-2-(4... 2 11
Cyclin-dependent kinase 2 Inhibitor 2-anilino-6-cyclohexylmeth... 4 13
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Peptide deformylase, mitochondrial Inhibitor 8-(2,3,4-trimetho... 8 15
Methylated-DNA--protein-cysteine methyltransferase Inhibitor 6... 4 5
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1... 17 100
Serine/threonine-protein kinase Chk2 Inhibitor 5-nitro-2-(4-ph... 6 3
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 3 23
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 7-et... 7 57
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-[3-(4-... 7 128
Adenosine receptor A1 and Adenosine receptor A2a Ligand GW-328... 26 94
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 8 8
Platelet-derived growth factor receptor alpha and Fibroblast g... 3 47
Melanin-concentrating hormone receptor 1 Ligand ADS-103214 Family 3 4
Adenosine receptor A1 and Adenosine receptor A2a Ligand N6-met... 21 57
TGF-beta receptor type-1 Ligand SB-431542 Family 2 42
Fatty-acid amide hydrolase 1 Inhibitor BMS-1 Family 5 22
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
Corticotropin-releasing factor receptor 1 Ligand BMS-561388 Fa... 10 16
Serine/threonine-protein kinase mTOR Inhibitor (4-(6-morpholin... 2 11
Platelet-derived growth factor receptor alpha and Platelet-der... 3 18
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Sodium channel protein type 5 subunit alpha Ligand Enecadin Fa... 1 11
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 10 46
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 2 22
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Tyrosine-protein kinase Lck inhibitor 4-N-(2-chloro-6-methylph... 8 45
Adenosine receptor A3 and Adenosine receptor A2a ligand AGN-PC... 3 4
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Vascular endothelial growth factor receptor 2 and Angiopoietin... 2 11
Aurora kinase A inhibitor SureCN208325 family 1 5
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN97387... 4 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 11
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 7 16
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 4 18
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 6 7
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 9 3
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 7 5
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Su... 2 16
Cathepsin S and Cathepsin K inhibitor SureCN1629664 family 10 11
Adenosine receptor A3 and Adenosine receptor A2a ligand 4-(5-b... 2 5
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
Glucocorticoid receptor ligand (2R)-1,1,1-trifluoro-4-(2-metho... 2 5
Casein kinase I isoform delta and Mitogen-activated protein ki... 3 18
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 19 11
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 10
Melatonin receptor type 1A ligand N-[2-(5-methoxy-2-phenyl-1H-... 1 2
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 14
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 4
Cellular tumor antigen p53 and Prelamin-A/C inhibitor CHEMBL14... 2 11
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 3 20
D(3) dopamine receptor and D(2) dopamine receptor ligand 2-[4-... 2 3
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Epidermal growth factor receptor ligand Pyrimido[4,5-b]indole ... 1 4
Tyrosine-protein kinase JAK2 inhibitor 5-(3-methoxyphenyl)-N-[... 2 11
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 6
Neuropeptide Y receptor type 5 ligand 3-[2-[6-[2-[(2-methylpro... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Prostaglandin D2 receptor ligand 2-[3-[2-methoxy-6-[2-(4-metho... 4 12
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 5
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Serine/threonine-protein kinase Chk2 and Serine/threonine-prot... 1 0
Adenosine receptor A3 ligand AGN-PC-08WSLM family 5 22
Adenosine receptor A1 and Adenosine receptor A3 ligand AGN-PC-... 6 8
Transient receptor potential M8 protein ligand (3E)-3-[5-[2-(t... 4 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 6 12
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Melanin-concentrating hormone receptor 1 ligand SureCN3334861 ... 1 3
Calmodulin-domain protein kinase 1 and Tyrosine-protein kinase... 5 5
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 0
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 9 10
Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... 3 1
Tyrosine-protein kinase JAK2 inhibitor (2S)-1-[4-[4-[[7-(2-met... 11 27
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 2
Acyl-CoA desaturase 1 and Acyl-CoA desaturase inhibitor 2-[4-[... 2 6
Corticotropin-releasing factor receptor 1 ligand N-(dicyclopro... 5 1
Cathepsin K and Cathepsin L1 inhibitor CHEBI:43424 family 2 0
Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 2 1
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 7 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 2
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 2
Interleukin-1 receptor-associated kinase 4 and Interleukin-1 r... 4 0
Insulin-like growth factor 1 receptor ligand 4-(2,3-dihydroind... 1 0
Macrophage colony-stimulating factor 1 receptor and Ephrin typ... 1 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 8 1
Mitogen-activated protein kinase 14 inhibitor AGN-PC-075YQ1 fa... 4 0
Serine/threonine-protein kinase B-raf and RAF proto-oncogene s... 1 0
Estrogen receptor beta and Estrogen receptor ligand SureCN6442... 1 2
Histamine H3 receptor ligand AGN-PC-075YXY family 1 4
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 8 6
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 2 8
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 6
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-07... 1 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN6387344 f... 6 11
Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... 12 2
Dual specificity protein kinase TTK inhibitor 2-[1-[4-[[6-(cyc... 8 0
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Vascular endothelial growth factor receptor 2 and Vascular end... 4 2
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 7 16
Somatostatin receptor type 3 and Potassium voltage-gated chann... 3 0
Activated CDC42 kinase 1 inhibitor N,N-dimethyl-4-[4-[[(2S)-ox... 4 2
Activated CDC42 kinase 1 inhibitor 5-(2-fluorophenyl)-N-[[(2S)... 5 0
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 2
Growth hormone secretagogue receptor type 1 ligand SureCN36800... 14 42
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 18 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2
Tyrosine-protein kinase Lck inhibitor 3-[[2-(benzimidazol-1-yl... 2 0
CGMP-dependent protein kinase inhibitor 1-[2-(4-fluorophenyl)-... 1 4
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Neuropeptide Y receptor type 5 ligand 6-ethylsulfonyl-2-(4-phe... 4 4
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Arachidonate 15-lipoxygenase inhibitor SureCN14288120 family 3 12
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
cGMP-dependent 3',5'-cyclic phosphodiesterase inhibitor SureCN... 4 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Diacylglycerol O-acyltransferase 1 inhibitor 4-[5-[5-(1H-benzi... 7 1
Tyrosine-protein kinase JAK2 inhibitor (2R)-2-[4-[[8-(4-methox... 2 0
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5
Mitogen-activated protein kinase kinase kinase 11 and Leucine-... 1 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 8-[(6,7... 6 8
Adenosine receptor A2a ligand 8-(3-fluorophenyl)-3-[2-[4-[4-(2... 5 0
Collagenase 3 inhibitor 1-[6-[4-(1H-benzimidazol-2-yl)phenoxy]... 3 0
Melanin-concentrating hormone receptor 1 ligand SureCN5431614 ... 1 2
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 6 2
Leukotriene A-4 hydrolase inhibitor AGN-PC-00EW8S family 1 2
Histamine H1 receptor ligand N-[6-[2-[(4-methoxyphenyl)methyl-... 2 1
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 2 6
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074EV8... 1 0
Dihydrofolate reductase inhibitor AGN-PC-001U7R family 3 0
Sterol O-acyltransferase 1 inhibitor 1,1-bis[5-[[4,5-bis(4-met... 1 15
Insulin-like growth factor 1 receptor ligand 3-[8-amino-1-(4-e... 9 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 16 0
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 1
Glucagon receptor ligand SureCN2647807 family 3 7
Cyclin-dependent kinase 1 inhibitor AGN-PC-075VQQ family 2 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 1 0
Cyclin-dependent kinase 1 and Receptor tyrosine-protein kinase... 2 3
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 4 4
Cholecystokinin receptor type A ligand AGN-PC-077L8J family 22 2
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 15 1
Rho-associated protein kinase 2 inhibitor SureCN1519463 family 5 1
Oxytocin receptor and Vasopressin V1a receptor ligand AGN-PC-0... 4 3
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 8
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 3 5
Epidermal growth factor receptor ligand Pyrido[3,4-d]pyrimidin... 3 1
D(2) dopamine receptor ligand AGN-PC-07C1V6 family 2 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
LIM domain kinase 2 and LIM domain kinase 1 inhibitor SureCN36... 1 1
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-07CR... 4 0
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 1
Potassium voltage-gated channel subfamily H member 2 and Melan... 2 1
Lysosomal Pro-X carboxypeptidase inhibitor 4-[6-[(2S)-2-(5,6-d... 2 2
Angiopoietin-1 receptor ligand 4-[4-(6-methoxynaphthalen-2-yl)... 6 4
Multidrug resistance-associated protein 1 inhibitor SureCN6823... 1 0
Cysteine protease and Cathepsin L1 inhibitor AGN-PC-076NDO family 1 0
Histamine H3 receptor ligand [4-[2-[2-(1H-imidazol-5-yl)ethyls... 1 0
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 1 0
Neuropeptide Y receptor type 5 ligand 7-methoxy-2-methyl-6-phe... 1 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00246191 DNC006539 Investigative Drug 2-(4-methoxyphenyl)-6-phenyl-9H-purine
CFAMM00246204 DNC006543 Investigative Drug 2,6-bis(4-methoxyphenyl)-9H-purine
CFAMM00246203 DNC005313 Investigative Drug Cyclohexyl-(2-phenoxy-9H-purin-6-yl)-amine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26830 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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