CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1693
Family Name Adenosine receptor A3 Ligand 4-methoxy-2-phenyl-2h-pyrazolo[4,3-c]quinoline Family
No. of Seeds 9 No. of Other Members 49
Family Centroid CFAMM00246345 Functional Category Investigative Drug with Natural Product
Superfamily Adenosine receptor A3 Ligand 4-methoxy-2-phenyl-2h-pyrazolo[4,3-c]quinoline Superfamily
Class Class 2208

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
DNA Binder Primaquine Family 3 245
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
DNA Binder Elliptinium Acetate Family 11 116
Citric Acid family 2 58
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 11 49
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Apricoxib family 8 77
Indeglitazar family 3 39
PF-02545920 family 16 140
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 11 41
Cytochrome b Inhibitor 2-nonyl-4-hydroxyquinoline N-OXIDE Family 2 22
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Plasminogen and Prothrombin Inhibitor 2-(2-hydroxy-phenyl)-1h-... 3 69
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor alpha and Platelet-der... 2 14
D(2) dopamine receptor and D(3) dopamine receptor Ligand L-741... 9 73
5-hydroxytryptamine receptor 2A Ligand [2-(6-methoxy-indol-1-y... 2 10
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Oestrogen receptor and Estrogen receptor beta Ligand ZK-119010... 2 16
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 13 26
D(2) dopamine receptor Ligand SLV-314 Family 19 69
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 11 12
Oestrogen receptor and Estrogen receptor beta Ligand 4-(3-phen... 5 14
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Acetylcholinesterase and Cholinesterase Inhibitor 6-hydroxy-1,... 4 2
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Indoleamine 2,3-dioxygenase 1 Inhibitor 5-aminoquinolin-8-ol F... 3 16
DNA topoisomerase 1 Inhibitor 3-(4-phenyl-2,4'-bipyridin-6-yl)... 4 13
Glucocorticoid receptor Ligand 1-(3-chloro-4-fluorophenyl)-2,2... 1 13
5-hydroxytryptamine receptor 2A and Alpha-2A adrenergic recept... 4 29
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 9 22
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 4 0
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074YUW... 2 9
Sigma non-opioid intracellular receptor 1 ligand 1'-butyl-6-me... 23 0
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 2 10
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 8 10
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 5
Smoothened homolog inhibitor AGN-PC-088VBV family 1 2
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 5 40
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 2 10
Hypoxia-inducible factor 1-alpha and Lethal factor inhibitor C... 1 1
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(2-... 3 3
DNA-(apurinic or apyrimidinic site) lyase and Ras-related prot... 1 6
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL15681... 1 5
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 2
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-00CFYH ... 2 1
5-hydroxytryptamine receptor 6 ligand SureCN5498885 family 5 4
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 9 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Histone deacetylase 1 and Potassium voltage-gated channel subf... 1 0
Sigma non-opioid intracellular receptor 1 ligand 6-methoxy-1'-... 2 0
Muscarinic acetylcholine receptor M3 ligand 3-fluoro-2-(3-pipe... 3 1
Glucocorticoid receptor ligand [(4aR,5S)-1-(4-fluorophenyl)-4a... 7 1
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 0
Corticotropin-releasing factor receptor 1 ligand 2-(2-ethyl-4,... 4 9
Platelet-derived growth factor receptor beta and Receptor-type... 1 2
Platelet-derived growth factor receptor beta and Receptor-type... 6 5
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 10
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 33 5
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Platelet-derived growth factor receptor beta and Macrophage co... 8 0
D(3) dopamine receptor and D(2) dopamine receptor ligand Piper... 3 14
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 5
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
Potassium voltage-gated channel subfamily H member 2 and 5-hyd... 2 2
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 6 4
Prostaglandin D2 receptor 2 ligand 2-[4-(difluoromethoxy)-2-et... 1 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN6786541 f... 3 6
Proto-oncogene tyrosine-protein kinase receptor Ret ligand Sur... 1 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor Sure... 13 9
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor AGN-... 2 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN4806204 f... 13 7
D(2) dopamine receptor and D(4) dopamine receptor ligand AGN-P... 1 0
Serine/threonine-protein kinase Chk1 and Aurora kinase B inhib... 14 0
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 1 2
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 10 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... 2 0
Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... 3 2
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
Protein kinase C theta type and Protein kinase C delta type in... 10 7
B2 bradykinin receptor ligand SureCN13145573 family 7 6
B2 bradykinin receptor and Cytochrome P450 3A4 ligand SureCN15... 4 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 2
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 7 1
Glutamate receptor ionotropic, NMDA 1 ligand SureCN8971235 family 1 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 1 1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 2 4
Tyrosine-protein kinase ITK/TSK inhibitor N-[(3Z)-3-(6-methoxy... 2 4
Adenosine receptor A1 ligand 4-amino-2-phenyl-3H-pyrazolo[3,4-... 1 0
Acetylcholinesterase and Cholinesterase inhibitor P10358 family 2 0
Thyroid hormone receptor beta and TGF-beta receptor type-1 lig... 1 1
Serine/threonine-protein kinase pim-3 and Serine/threonine-pro... 4 6
Metabotropic glutamate receptor 5 ligand AGN-PC-09SFJI family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00246322 CHEMBL176699 Bioactive 9-methoxy-2-phenyl-1H-pyrazolo[4,3-c]quinolin-3-one
CFAMM00246393 CHEMBL2425771 Bioactive SureCN4115851
CFAMM00246329 CHEMBL43948 Bioactive 7-methoxy-2-(4-methoxyphenyl)-1H-pyrazolo[4,3-c]quinolin-3-one
CFAMM00246375 CHEMBL115736 Bioactive SureCN9693833
CFAMM00246348 CHEMBL44613 Bioactive SureCN1467262
CFAMM00246383 CHEMBL44269 Bioactive 2-(3-methoxyphenyl)-1H-pyrazolo[4,3-c]quinolin-3-one
CFAMM00246365 CHEMBL48053 Bioactive SureCN1466891
CFAMM00246337 CHEMBL188035 Bioactive 2-(4-methylphenyl)-1H-pyrazolo[4,3-c]quinolin-4-one
CFAMM00246345 DNC005336 Investigative Drug 4-Methoxy-2-phenyl-2H-pyrazolo[4,3-c]quinoline

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27254 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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