CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1702
Family Name Prostacyclin receptor and Prostaglandin E2 receptor EP3 subtype Ligand FR-181157 Family
No. of Seeds 4 No. of Other Members 17
Family Centroid CFAMM00247487 Functional Category Investigative Drug
Superfamily Cyclooxygenase Inhibitor Oxaprozin Superfamily
Class Class 369

Cousin Family NamesSeedsMembers
Cyclooxygenase Inhibitor Oxaprozin Family 33 450
Egl nine homolog 2 Inhibitor FG-4592 Family 1 4
Peroxisome proliferator-activated receptor alpha Ligand Alegli... 29 7
Substance-P receptor Ligand R 673 Family 2 127
Peroxisome proliferator-activated receptor gamma and Peroxisom... 15 94
Melatonin receptor type 1B Ligand N-(3-benzooxazol-7-yl-propyl... 26 101
Oestrogen receptor and Estrogen receptor beta Ligand 2-naphtha... 4 51
Oestrogen receptor and Estrogen receptor beta Ligand 2-(6-hydr... 9 22
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3-[4-(4-hydroxyphe... 1 4
Leukotriene A-4 hydrolase Inhibitor 2-[4-(2-azepan-1-ylethoxy)... 5 15
Peroxisome proliferator-activated receptor alpha Ligand BMS-68... 10 16
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 1 4
Fatty-acid amide hydrolase 1 Inhibitor 3-(benzo[d]oxazol-2-yl)... 1 6
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 4 4
Peroxisome proliferator-activated receptor delta ligand AGN-PC... 7 27
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 7
Peroxisome proliferator-activated receptor delta ligand SureCN... 8 19
Muscarinic acetylcholine receptor M3 ligand [(3R)-1-[3-(1,3-be... 3 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 2 21
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 4 14
Prelamin-A/C inhibitor CHEMBL1374443 family 1 6
Thyroid hormone receptor beta ligand CHEMBL1397256 family 1 12
Aldose reductase inhibitor SureCN1590315 family 1 7
Thromboxane-A synthase and Thromboxane A2 receptor ligand Sure... 5 37
Inosine-5'-monophosphate dehydrogenase inhibitor SureCN1318237... 2 12
Fatty-acid amide hydrolase 1 inhibitor methyl 6-[2-[3-(4-pheny... 8 5
Fatty-acid amide hydrolase 1 inhibitor [(2S)-6-phenoxy-1,2,3,4... 3 6
Neprilysin and Natriuretic peptides A inhibitor (2S)-2-[[1-[[(... 3 3
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 4 1
Peroxisome proliferator-activated receptor gamma ligand AGN-PC... 5 12
Prostaglandin E2 receptor EP4 subtype ligand SureCN4876498 family 2 0
Integrin beta-1 and Integrin alpha-4 inhibitor 4-[[(2S,4S)-4-f... 4 7
Peroxisome proliferator-activated receptor gamma and Peroxisom... 4 1
Sphingosine 1-phosphate receptor 1 ligand 6-[2-[4-phenyl-3-(tr... 2 3
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 14 24
Prostaglandin E2 receptor EP4 subtype and Prostaglandin E2 rec... 7 1
Sphingosine 1-phosphate receptor 1 ligand AGN-PC-00DWQL family 2 2
Peroxisome proliferator-activated receptor gamma and Peroxisom... 1 3
Peroxisome proliferator-activated receptor alpha and Peroxisom... 5 2
Peroxisome proliferator-activated receptor gamma and Peroxisom... 10 5
Peroxisome proliferator-activated receptor gamma and Peroxisom... 3 0
Peroxisome proliferator-activated receptor gamma and Peroxisom... 5 0
Peroxisome proliferator-activated receptor alpha and Peroxisom... 2 1
Peroxisome proliferator-activated receptor alpha ligand 5-[4-[... 1 0
Peroxisome proliferator-activated receptor delta and Peroxisom... 1 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(2,6-di... 2 4
Peroxisome proliferator-activated receptor gamma and Peroxisom... 7 2
Peroxisome proliferator-activated receptor alpha and Peroxisom... 1 0
Leukotriene A-4 hydrolase inhibitor SureCN3030546 family 9 1
Peroxisome proliferator-activated receptor gamma and Peroxisom... 4 3
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 5 5
Peroxisome proliferator-activated receptor gamma and Tyrosine-... 1 0
Protein farnesyltransferase subunit beta and Protein farnesylt... 1 3
Arachidonate 5-lipoxygenase inhibitor (4E)-4-[(E,4Z)-4-(3H-1,3... 6 6


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00247480 CHEMBL126078 Bioactive SureCN9428317
CFAMM00247487 DNC005388 Investigative Drug FR-181157
CFAMM00247484 DNC005394 Investigative Drug FR-193262

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26400 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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