CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1707
Family Name Acetylcholinesterase and Cholinesterase Inhibitor 3-[7-(benzylmethylamino)-heptyloxy]xanthen-9-one Family
No. of Seeds 22 No. of Other Members 303
Family Centroid CFAMM00247647 Functional Category Investigative Drug with Natural Product
Superfamily Muscarinic acetylcholine receptor Ligand Flavoxate Superfamily
Class Class 288

Cousin Family NamesSeedsMembers
D(2) dopamine receptor Ligand Remoxipride Family 12 84
Sodium channel protein type 5 subunit alpha Ligand Dyclonine F... 6 174
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Vitamin K epoxide reductase complex subunit 1 Inhibitor Warfar... 9 508
Heat shock protein 90, putative Inhibitor Cromoglicate Family 14 2827
DNA Binder Methoxsalen Family 10 1638
Muscarinic acetylcholine receptor Ligand Flavoxate Family 9 350
D-alanyl-D-alanine carboxypeptidase Inhibitor B-lactams Family 59 1364
Ipriflavone family 62 2480
Rotenone family 16 107
Agrimophol family 10 22
Cyclin-dependent kinase 2 Inhibitor Flavopiridol Family 4 124
Leukotriene B4 receptor 1 Ligand LY293111 Family 24 79
Steryl-sulfatase Inhibitor Stx 64 Family 7 160
C-C chemokine receptor type 5 Ligand GW873140 Family 6 78
Integrin alpha-4 Inhibitor Firategrast Family 3 93
Celivarone family 1 1
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 3 89
Plasmepsin-2 Inhibitor PS-662477 Family 7 55
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Oxytocin receptor and Vasopressin V1a receptor Ligand L-371257... 8 92
Leukotriene B4 receptor 1 Ligand SC-51146 Family 6 315
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 8 66
DNA-dependent protein kinase catalytic subunit Inhibitor 7-pro... 5 49
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 14
Histamine H3 receptor Ligand A-349821 Family 49 228
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
Caspase-3 Inhibitor 2-(4-methoxy-benzyl)isoquinoline-1,3,4-tri... 2 2
Oestrogen receptor and Estrogen receptor beta Ligand 3,8-dihyd... 20 57
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Acetylcholinesterase Inhibitor AP-2238 Family 2 109
Cytosolic phospholipase A2 Inhibitor [6,3''']biflavone Family 5 5
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
Beta-2 adrenergic receptor Ligand Gnf-pf-1694 Family 4 70
Acetylcholinesterase Inhibitor Taspine Family 1 0
Amine oxidase [flavin-containing] B Inhibitor (s)(+)-7-fluoro-... 11 11
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Cytochrome P450 3A4 Inhibitor Diethoxyflourescein Family 3 9
Epidermal growth factor receptor Ligand 3-(3-chloro-phenyl)-5,... 10 64
Prostaglandin G/H synthase 2 Inhibitor 3,4-dibenzyloxy-2'-hydr... 7 40
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 3 27
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Liver carboxylesterase 1 Inhibitor 2-methoxy-3,4-methylenediox... 4 26
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 4 10
Acetylcholinesterase inhibitor [3-[[methyl-[7-[[(2E)-1-oxo-2-[... 2 0
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 20 9
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 10 8
Multidrug resistance protein 1 inhibitor 1-[2-[(2R)-3-[4-(2,3-... 2 41
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 4
Mu-type opioid receptor ligand 3-[(3R,4R)-1-[(2,4-dimethoxyphe... 2 4
D(4) dopamine receptor and D(3) dopamine receptor ligand 3-ben... 5 334
Histamine H3 receptor ligand SureCN2784769 family 12 2
Sigma non-opioid intracellular receptor 1 and Vesicular acetyl... 3 7
Peroxisome proliferator-activated receptor gamma ligand (9aS)-... 4 44
Melanin-concentrating hormone receptor 1 and Potassium voltage... 12 53
Potassium voltage-gated channel subfamily H member 2 and Melan... 5 4
Estrogen receptor ligand 2-(3-hydroxy-6-oxoxanthen-9-yl)-5-[[4... 1 2
C-C chemokine receptor type 1 and Chemokine (C-C motif) recept... 1 16
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 1 5
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 11
Estrogen receptor beta and Estrogen receptor ligand AGN-PC-074... 5 4
Acetylcholinesterase and Cholinesterase inhibitor Xanthostigmi... 1 1
Acetylcholinesterase and Butyrylcholinesterase inhibitor [3-[[... 1 65
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 2 9
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 4 3
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase and Prelamin... 1 0
DNA-dependent protein kinase catalytic subunit inhibitor 5-hyd... 1 7
Nuclear receptor ROR-gamma ligand 3-(1,3-benzodioxol-5-yl)-1-(... 3 36
Breast cancer type 1 susceptibility protein and Huntingtin inh... 1 7
Cholesteryl ester transfer protein inhibitor [8-[(1S)-1-hydrox... 4 10
Collagenase 3 inhibitor ethyl 4-[4-[2-[(3S)-3-hydroxy-1-azabic... 1 0
Acetylcholinesterase inhibitor 4-[(2-methoxyanilino)methyl]-[1... 2 4
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 5 activa... 2 110
Cathepsin D inhibitor (E)-N-butyl-4-[1-(3,4,5-trimethoxybenzoy... 1 3
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 7
Estrogen receptor ligand AGN-PC-073KIM family 1 0
Calpain-1 catalytic subunit inhibitor (3S)-3-[[4-[2-(methoxyme... 2 4
Acetylcholinesterase and Butyrylcholinesterase inhibitor (2Z)-... 2 10
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07R9XR fa... 1 7
D(1A) dopamine receptor and D(3) dopamine receptor ligand 7-[3... 1 12
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 1 11
Putative NP ZINC08790414 Family 23 0
NP (z)-2-(4-isopropylbenzylidene)-3-oxo-2,3-dihydrobenzofuran-... 16 0
Putative NP ZINC02127056 Family 4 1
Putative NP ZINC20762875 Family 7 1
Putative NP ZINC08790868 Family 10 0
oxybenzoate NP ZINC04029407 Family 4 1
Putative NP ZINC02124510 Family 1 0
2-amino-3-methylpentanoate NP 2-((3-(4-fluorophenoxy)-4-oxo-4h... 13 2
NP 2-((5-hydroxy-2,2-dimethyl-4-oxochroman-7-yl)oxy)-n-(3-meth... 18 0
Putative NP ZINC00174842 Family 4 0
Putative NP ZINC04085259 Family 3 0
NP 7-(2-((4as,8as)-4a-hydroxyoctahydroisoquinolin-2(1h)-yl)-2-... 3 0
hydroxyspiro[3H-chromene-2,4'-piperidine]-4-one NP 1'-acetyl-7... 2 1
NP 1,3,8-trihydroxy-6-methyl-2-(morpholinomethyl)anthracene-9,... 2 0
4-methyl-7-[(4-methylpiperazin-1-ium-1-yl)methyl]-3-oxo-1-benz... 14 0
1-benzofuran-3-one NP ZINC02445091 Family 23 0
Putative NP ZINC20357755 Family 11 0
6-hydroxy-7-(morpholin-4-ylmethyl)-1-benzofuran-3-one NP ZINC2... 7 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00247672 CHEMBL128202 Bioactive [3-[[ethyl-[3-(9-oxoxanthen-3-yl)oxypropyl]amino]methyl]phenyl] N-methylcarbamate
CFAMM00247807 CHEMBL339039 Bioactive [3-[[ethyl-[3-(9-oxoxanthen-3-yl)oxypropyl]amino]methyl]phenyl] N-butylcarbamate
CFAMM00247933 CHEMBL1085278 Bioactive aminoalkoxyaryl deriv. 12c
CFAMM00247732 CHEMBL543655 Bioactive AGN-PC-07C00C
CFAMM00247964 CHEMBL124933 Bioactive aminoalkoxyaryl deriv. 12a
CFAMM00247689 CHEMBL131219 Bioactive [3-[[3-(9-oxoxanthen-3-yl)oxypropyl-propylamino]methyl]phenyl] N-methylcarbamate
CFAMM00247823 CHEMBL128471 Bioactive [3-[[methyl-[3-(4-oxo-2-phenylchromen-7-yl)oxypropyl]amino]methyl]phenyl] N-methylcarbamate
CFAMM00247910 CHEMBL131579 Bioactive [3-[[3-(9-oxoxanthen-3-yl)oxypropyl-propan-2-ylamino]methyl]phenyl] N-methylcarbamate
CFAMM00247867 CHEMBL189957 Bioactive Xanthostigmine deriv. 2
CFAMM00247895 CHEMBL557405 Bioactive AGN-PC-07C2AO
CFAMM00247680 CHEMBL337999 Bioactive aminoalkoxyheteroaryl deriv. 6
CFAMM00247646 DNC007324 Investigative Drug 3-[8-(benzylmethylamino)octyloxy]xanthen-9-one
CFAMM00247907 DNC007331 Investigative Drug 3-[10-(benzylmethylamino)decyloxy]xanthen-9-one
CFAMM00247645 DNC007323 Investigative Drug 3-[3-(benzylmethylamino)propoxy]xanthen-9-one
CFAMM00247906 DNC007332 Investigative Drug 3-[9-(benzylmethylamino)nonyloxy]xanthen-9-one
CFAMM00247644 DNC007329 Investigative Drug 3-[12-(benzylmethylamino)dodecyloxy]xanthen-9-one
CFAMM00247643 DNC007328 Investigative Drug 3-[4-(benzylmethylamino)butoxy]xanthen-9-one
CFAMM00247649 DNC007327 Investigative Drug 3-[5-(benzylmethylamino)pentyloxy]xanthen-9-one
CFAMM00247648 DNC007326 Investigative Drug 3-[6-(benzylmethylamino)hexyloxy]xanthen-9-one
CFAMM00247935 DNC005402 Investigative Drug XANTHOSTIGMINE
CFAMM00247647 DNC007325 Investigative Drug 3-[7-(benzylmethylamino)-heptyloxy]xanthen-9-one
CFAMM00247908 DNC007330 Investigative Drug 3-[11-(benzylmethylamino)undecyloxy]xanthen-9-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27430 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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