CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1714
Family Name Liver carboxylesterase 1 Inhibitor 1,2-bis(2,5-difluorophenyl)-2-hydroxyethanone Family
No. of Seeds 12 No. of Other Members 10
Family Centroid CFAMM00248074 Functional Category Investigative Drug with Human Metabolite
Superfamily Liver carboxylesterase 1 Inhibitor 1,2-bis(2,5-difluorophenyl)-2-hydroxyethanone Superfamily
Class Class 2215

Cousin Family NamesSeedsMembers
Prostaglandin G/H synthase 2 Inhibitor Diflunisal Family 7 421
Retinoid X receptor Ligand Bexarotene Family 7 492
Aldehyde oxidase inhibitor para-naphthoquinone Menadione Family 22 503
Cyclooxygenase Inhibitor Flurbiprofen Family 18 294
Prostaglandin G/H synthase 2 Inhibitor Ketoprofen Family 5 84
DNA topoisomerase 2-beta Inhibitor Salvicine Family 2 9
DNA topoisomerase 1 Inhibitor Beta-lapachone Family 3 66
Dihydroorotate dehydrogenase Inhibitor Dichloroallyl Lawsone F... 1 1
Dihydroorotate dehydrogenase Inhibitor Polyporic Acid Family 4 13
Carbonic anhydrase 2 Inhibitor 4-(hydroxymercury)benzoic Acid ... 7 97
Steryl-sulfatase Inhibitor Sulfamic Acid 3-(4-hydroxy-benzoyl)... 3 2
Estrogen receptor beta Ligand 3,6-dihydroxy-2-(4-hydroxy-pheny... 2 23
C-X-C chemokine receptor type 1 and C-X-C chemokine receptor t... 2 53
Liver carboxylesterase 1 Inhibitor 2,2-dimethoxy-1,2-diphenyl-... 1 16
4-aminobutyrate aminotransferase, mitochondrial and Succinate-... 4 22
Glutamate carboxypeptidase 2 Inhibitor 2-(3-carboxybenzyl)succ... 2 7
Glutamate carboxypeptidase 2 Inhibitor 3-(2-carboxy-6-mercapto... 9 4
Gamma-secretase subunit APH-1B and Presenilin-1 Inhibitor (5r,... 3 9
Tyrosine-protein phosphatase non-receptor type 1 Ligand Licoag... 9 32
Thyroid hormone receptor beta Ligand (4-hexylphenyl)(oxiran-2-... 1 16
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3-(6-hydroxy-2-nap... 7 9
Solute carrier family 52, riboflavin transporter, member 2 Inh... 1 7
Fatty-acid amide hydrolase 1 Inhibitor 3-(ethoxycarbonyl)pheny... 2 69
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 18
Beta-lactamase inhibitor CHEMBL1358094 family 1 10
Indanes Metabolite (R)-Pterosin B Family 5 8
carboxylate NP ZINC04026424 Family 3 7


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00248078 DNC007668 Investigative Drug 1,2-bis(2,3-difluorophenyl)-2-hydroxyethanone
CFAMM00248054 DNC007670 Investigative Drug 1,2-bis(2,6-difluorophenyl)-2-hydroxyethanone
CFAMM00248077 DNC007669 Investigative Drug 1,2-bis(3,4-difluorophenyl)-2-hydroxyethanone
CFAMM00248053 DNC007673 Investigative Drug 1,2-bis(2-fluorophenyl)-2-hydroxyethanone
CFAMM00248076 DNC007663 Investigative Drug 1,2-bis(3,4,5-trifluorophenyl)-2-hydroxyethanone
CFAMM00248052 DNC007672 Investigative Drug 1,2-bis(3-fluorophenyl)-2-hydroxyethanon
CFAMM00248075 DNC007666 Investigative Drug 1,2-bis(3,5-difluorophenyl)-2-hydroxyethanone
CFAMM00248050 DNC007671 Investigative Drug 1,2-bis(2,4-difluorophenyl)-2-hydroxyethanone
CFAMM00248074 DNC007667 Investigative Drug 1,2-bis(2,5-difluorophenyl)-2-hydroxyethanone
CFAMM00248082 DNC005432 Investigative Drug BENZOIN
CFAMM00248073 DNC007664 Investigative Drug 1,2-bis(2,3,4-trifluorophenyl)-2-hydroxyethanone
CFAMM00248072 DNC007665 Investigative Drug 1,2-bis(2,3,5-trifluorophenyl)-2-hydroxyethanone

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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