CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1729
Family Name Aurora kinase B and Aurora kinase C Inhibitor PHA-680632 Family
No. of Seeds 5 No. of Other Members 72
Family Centroid CFAMM00248544 Functional Category Investigative Drug
Superfamily Aurora kinase B and Aurora kinase A Inhibitor PHA-739358 Superfamily
Class Class 1152

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Macrophage colony-stimulating factor 1 Inhibitor ABT-869 Family 8 56
Aurora kinase B and Aurora kinase A Inhibitor PHA-739358 Family 6 29
PHA848125 family 13 138
Cyclin-dependent kinase 2 Inhibitor N-(5-cyclopropyl-1h-pyrazo... 6 62
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Adenosine receptor A1 and Adenosine receptor A2a Ligand OSIP-3... 4 31
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Glycogen synthase kinase-3 beta Inhibitor N-(6-(thiophen-3-yl)... 4 3
Metabotropic glutamate receptor 5 Ligand N-(1,3-diphenyl-1h-py... 6 37
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 4
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07ZYJE fa... 15 5
Sphingosine 1-phosphate receptor 1 ligand SureCN3029336 family 4 8
Orexin receptor type 2 and Orexin receptor type 1 ligand [(7R)... 10 10
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 3
Mitogen-activated protein kinase 14 inhibitor SureCN3632376 fa... 10 5
Platelet-activating factor receptor ligand SureCN9384429 family 11 3
Poly [ADP-ribose] polymerase 1 inhibitor 2-[2-[4-(1H-indazol-3... 1 0
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Aurora kinase A inhibitor SureCN3894803 family 5 8
TGF-beta receptor type-1 ligand 6-[4-ethyl-2-(6-methylpyridin-... 9 11
Mitogen-activated protein kinase kinase kinase kinase 5 and Du... 1 18
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M6OU fa... 8 7
Mitogen-activated protein kinase 14 inhibitor AGN-PC-069K8I fa... 12 3
Aurora kinase A inhibitor AGN-PC-00EHLC family 1 0
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family 8 15
Serine/threonine-protein kinase 17A and Myosin light chain kin... 3 7
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-0A9SI... 4 0
Mitogen-activated protein kinase 14 inhibitor N-ethyl-5-methyl... 17 3
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 13 3
Receptor-type tyrosine-protein kinase FLT3 and Vascular endoth... 2 6
Protein-tyrosine kinase 6 and KH domain-containing, RNA-bindin... 21 6
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 18
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 4 3
Mitogen-activated protein kinase 14 inhibitor ethyl N-[4-[5-(m... 5 2
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 10 0
Cell division cycle 7-related protein kinase and Casein kinase... 2 0
Aurora kinase B and Aurora kinase A inhibitor 4-amino-N-[3-[[(... 5 3
Receptor-type tyrosine-protein kinase FLT3 and Vascular endoth... 1 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase ITK/TS... 4 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 6 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 1
Metabotropic glutamate receptor 5 ligand 5-(4-fluorophenyl)-1,... 7 1
Receptor-type tyrosine-protein kinase FLT3 and Vascular endoth... 4 0
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Serine/threonine-protein kinase Chk1 inhibitor 5-[(2S)-3-amino... 4 6
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 10 9
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 4 4
B1 bradykinin receptor ligand SureCN6045964 family 2 1
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-04VNKY family 1 4
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor 1-[6,6-dimet... 1 0
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 1 2
Aurora kinase A and Aurora kinase B inhibitor SureCN4059106 fa... 1 0
Serine/threonine-protein kinase D1 inhibitor 3-[5-[3-bromo-4-(... 1 1
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor 3-Aminopyraz... 1 0
Aurora kinase A and Tyrosine-protein kinase SYK inhibitor AGN-... 1 0
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor N-[5-(2,2-di... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00248586 CHEMBL2386790 Bioactive N-[5-[3-methyl-4-[(5-methyl-1,2-oxazol-3-yl)carbamoylamino]phenyl]-1H-pyrazol-3-yl]-4-(4-methylpiperazin-1-yl)benzamide
CFAMM00248579 CHEMBL192602 Bioactive 3-Aminopyrazole deriv. 24
CFAMM00248554 CHEMBL190446 Bioactive AC1NSA07
CFAMM00248544 DNC005484 Investigative Drug PHA-680632

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26240 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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