CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1739
Family Name Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-chloro-phenyl)-3-cyclohexyl-urea Family
No. of Seeds 5 No. of Other Members 50
Family Centroid CFAMM00248788 Functional Category Investigative Drug
Superfamily Bifunctional epoxide hydrolase 2 Binder Superfamily
Class Class 1917

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Sodium channel Ligand iminostilbene derivative (tricyclic stru... 2 46
Dopamine receptor Ligand Domperidone Family 2 21
Peptide deformylase, mitochondrial Inhibitor Proguanil Family 8 46
Sigma non-opioid intracellular receptor 1 Ligand MS-377 Family 1 21
Gamma-aminobutyric acid A receptor Ligand ELB-139 Family 1 3
Bifunctional epoxide hydrolase 2 Inhibitor 1-cyclohexyl-3-phen... 5 65
Bifunctional epoxide hydrolase 2 Inhibitor N-(3-chloro-phenyl)... 2 43
Androgen receptor Ligand YM-175735 Family 30 129
Carbonic anhydrase 2 and Carbonic anhydrase 4 Inhibitor 1-(3,4... 2 9
Cannabinoid receptor 1 Ligand 1-(bis(4-chlorophenyl)methyl)-3-... 4 44
Kinesin-like protein KIF11 Inhibitor N-[4'-(trifluoromethyl)-4... 7 134
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
MO15-related protein kinase Pfmrk Inhibitor 2-chloro-n-(o-toly... 6 28
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 3 34
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 45
Tyrosinase Inhibitor 1-hydroxy-3-phenylurea Family 2 10
Tyrosinase Inhibitor 1-hydroxy-3-(4-(trifluoromethyl)phenyl)ur... 2 3
DNA topoisomerase Inhibitor 6-(3-iodo-phenylamino)-1h-pyrimidi... 2 5
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 4 18
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-07ZBI0 family 2 16
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C8 inhib... 6 5
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 2 0
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 5 5
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-(3-... 6 12
Melanin-concentrating hormone receptor 1 ligand 3-(3-chloro-4-... 8 24
Survival motor neuron protein and Retinal dehydrogenase 1 inhi... 1 1
Substance-P receptor ligand (2S,4S)-2-N-[3-(diethylamino)propy... 2 7
C-C chemokine receptor type 2 and C-C chemokine receptor type ... 2 8
D(3) dopamine receptor and D(2) dopamine receptor ligand 3-[4-... 4 23
Melanin-concentrating hormone receptor 1 ligand 1-[[4-[4-(3-cy... 14 23
Melanin-concentrating hormone receptor 1 ligand SureCN3845324 ... 7 4
C-C chemokine receptor type 1 ligand SureCN3159355 family 7 9
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 5 2
D(3) dopamine receptor and D(2) dopamine receptor ligand RGH-1... 8 0
Melanin-concentrating hormone receptor 1 ligand SureCN14265866... 11 2
Inosine-5'-monophosphate dehydrogenase inhibitor 1-[4-chloro-3... 3 5
Inosine-5'-monophosphate dehydrogenase inhibitor 1-(3,4-dichlo... 1 1
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor 1-(4-c... 1 0
Histamine H3 receptor and Histamine receptor H3 ligand 1-(3,5-... 4 0
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 3
Kappa-type opioid receptor ligand AGN-PC-077Q4Y family 5 9
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 4 1
Melanin-concentrating hormone receptor 1 ligand SureCN13451707... 3 1
Neuropeptide Y receptor type 5 ligand SureCN6214451 family 3 1
Potassium voltage-gated channel subfamily H member 2 and D(3) ... 3 0
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-(3-... 2 1
Bloom syndrome protein and Prelamin-A/C inhibitor DCEBIO family 1 1
Acyl-CoA:cholesterol acyltransferase inhibitor 1-[2,6-di(propa... 7 2
DNA polymerase III PolC-type inhibitor 6-(3-chloro-4-methylani... 1 1
Glycogen phosphorylase, liver form inhibitor TCMDC-135759 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00248804 CHEMBL2031928 Bioactive 1-(3-chlorophenyl)-3-(cyclohexylmethyl)urea
CFAMM00248796 CHEMBL1818404 Bioactive 1-(3-chloro-4-methylphenyl)-3-cyclooctylurea
CFAMM00248794 CHEMBL1818403 Bioactive 1-(3-chloro-4-methylphenyl)-3-heptylurea
CFAMM00248788 DNC005562 Investigative Drug 1-(3-Chloro-phenyl)-3-cyclohexyl-urea
CFAMM00248832 DNC014622 Investigative Drug 1-(4-Chloro-phenyl)-3-(3-pentyl-oct-2-enyl)-urea

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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