CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1741
Family Name Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family
No. of Seeds 4 No. of Other Members 23
Family Centroid CFAMM00248939 Functional Category Investigative Drug with Natural Product
Superfamily Fatty-acid amide hydrolase 1 and Histone deacetylase 1 Binder Superfamily
Class Class 1579

Cousin Family NamesSeedsMembers
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Beta-1 adrenergic receptor Ligand Acebutolol Family 2 27
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Acetylcholinesterase Inhibitor Neostigmine Family 4 76
Cyclooxygenase Inhibitor Acetaminophen Family 2 42
Beta-1 adrenergic receptor Ligand Practolol Family 2 82
Acyl-CoA desaturase Inhibitor Isoxyl Family 5 62
Histamine H1 receptor Ligand Tranilast Family 5 125
D(2) dopamine receptor Ligand Pardoprunox Family 4 81
D(4) dopamine receptor Ligand PD-165167 Family 2 96
Tumor necrosis factor Inhibitor Tgaac-94 Family 6 107
Transforming growth factor-beta Inhibitor ACE-011 Family 1 13
Tasquinimod family 1 4
Dihydroorotate dehydrogenase and Interleukin-17A Inhibitor Vid... 4 74
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Muscarinic acetylcholine receptor M1 Ligand AC-260584 Family 4 36
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
Liver carboxylesterase 1 Inhibitor CI-976 Family 1 32
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Glucose-6-phosphate 1-dehydrogenase Inhibitor Metazamide Family 9 69
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
Amine oxidase [flavin-containing] A Inhibitor Ethyl 4-(2-oxo-2... 4 117
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
Leukotriene A-4 hydrolase Inhibitor N-benzyl-4-[(2r)-pyrrolidi... 6 40
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor 5... 4 24
Oestrogen receptor and Estrogen receptor beta Ligand 2-(4-hydr... 10 17
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 18 12
MO15-related protein kinase Pfmrk Inhibitor 3-[3-(2-hydroxy-et... 1 6
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 6 23
Cytochrome P450 1B1 Inhibitor N-(2,4-dimethoxy-phenyl)-3,5-dim... 1 110
High affinity nerve growth factor receptor and RAF proto-oncog... 3 29
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Amyloid beta A4 protein Inhibitor SB-13 Family 1 2
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 12 46
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Histone deacetylase 1 Inhibitor 7-(4-(dimethylamino)phenoxy)-n... 2 1
Amyloid beta A4 protein Inhibitor 6-iodo-4'-methylaminoflavone... 3 33
Alpha-1A adrenergic receptor and D(2) dopamine receptor Ligand... 5 49
Histone deacetylase 2 Inhibitor N-(4-amino-3'-methoxybiphenyl-... 3 49
Histone deacetylase 2 Inhibitor 2-(benzyloxy)-n7-hydroxy-n1-ph... 1 3
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-(... 7 18
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 11 13
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Macrophage migration inhibitory factor Inhibitor 3-benzyl-5-me... 10 42
Amine oxidase [flavin-containing] B Inhibitor N-methyl-n-pheny... 6 25
Bifunctional epoxide hydrolase 2 Inhibitor 1-adamantan-1-yl-3-... 12 44
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-(3-morpholinop... 24 102
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 8 41
Leukotriene A-4 hydrolase Inhibitor 1-[4-(4-iodophenoxy)phenyl... 5 18
Proto-oncogene tyrosine-protein kinase receptor Ret Ligand (z)... 1 60
Fatty-acid amide hydrolase 1 Inhibitor 2-fluorophenyl 4-(octyl... 15 9
Fatty-acid amide hydrolase 1 Inhibitor Propan-2-one O-4-(hexyl... 12 4
Fatty-acid amide hydrolase 1 Inhibitor Benzaldehyde O-4-ethoxy... 21 4
Fatty-acid amide hydrolase 1 Inhibitor Phenylcarbamic Acid Bip... 3 7
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Fatty-acid amide hydrolase 1 Inhibitor Phenmedipham Family 2 5
Aromatase Inhibitor 2,3-dimethoxy-4'-amino-trans-stilbene Family 5 12
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 28
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-methoxy-phenyl)-... 1 3
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
Aldose reductase Inhibitor (6-hydroxy-2-oxo-2h-quinolin-1-yl)-... 3 4
Tyrosinase Inhibitor 1-(4-(benzyloxy)phenyl)-3-hydroxyurea Family 9 23
Metabotropic glutamate receptor 5 Ligand N-(3-(3-cyanobenzamid... 2 13
Liver carboxylesterase 1 Inhibitor SCH-48375 Family 2 28
Tubulin beta chain Inhibitor Gnf-pf-117 Family 2 16
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
3-oxo-5-alpha-steroid 4-dehydrogenase 2 and 3-oxo-5-alpha-ster... 3 5
Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]... 11 10
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEH3 family 3 16
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 14 12
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 4
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-N... 2 2
Survival motor neuron protein and DNA-(apurinic or apyrimidini... 1 5
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor SureCN... 2 11
Nuclear receptor ROR-gamma and Menin ligand CHEMBL1432265 family 1 18
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 6 16
Gastrin/cholecystokinin type B receptor ligand 1-[3-[[2-(3-met... 2 12
Histone deacetylase 6 and Histone deacetylase 1 inhibitor AGN-... 6 11
Potassium voltage-gated channel subfamily H member 2 and Melan... 9 4
Carbonic anhydrase 12 and Probable transmembrane carbonic anhy... 2 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Substance-P receptor ligand 1-[(5-amino-2-methoxyphenyl)methyl... 3 5
Transient receptor potential cation channel subfamily V member... 1 0
Dipeptidyl peptidase 4 inhibitor (2S)-1-[(2S,4S)-4-(4-methoxya... 1 26
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Cathepsin L1 and Cathepsin S inhibitor arylaminoethyl amide, 5... 4 5
Sphingosine 1-phosphate receptor 1 ligand 2-methoxy-N-[(4-phen... 2 23
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor [4-(2,... 2 11
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial ... 3 3
Cathepsin K inhibitor (1R,2R)-N-(cyanomethyl)-2-[4-(3-methoxyp... 2 1
Cathepsin K and Cathepsin S inhibitor (1R,2R)-N-(1-cyanocyclop... 4 0
Histamine H3 receptor and Histamine receptor H3 ligand 1-[4-[3... 2 0
2-acylglycerol O-acyltransferase 2 inhibitor N-(4-methoxypheny... 1 0
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 20 23
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 4 2
Hormone-sensitive lipase inhibitor SureCN7553414 family 1 1
Neuropeptide Y receptor type 5 ligand 1-[1-(4-fluorophenyl)pro... 2 8
Neuropeptide Y receptor type 5 ligand AGN-PC-01NRZ6 family 3 6
Substance-P receptor ligand CP 141938 family 1 0
P2X purinoceptor 7 inhibitor 2-(1-adamantyl)-N-(3-methoxy-2-me... 2 4
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 1 4
Neutrophil elastase inhibitor AGN-PC-04S1IE family 1 0
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 4 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 5 5
Lysophosphatidic acid receptor 2 and Lysophosphatidic acid rec... 1 0
Amyloid beta A4 protein inhibitor 2-(fluoranylmethyl)-3-[4-[(E... 1 3
fMet-Leu-Phe receptor ligand 2-[[(2S)-2-[[(2S)-2-[(4-methoxyph... 1 0
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 0
Protein-S-isoprenylcysteine O-methyltransferase inhibitor N-[2... 1 2
Amine oxidase [flavin-containing] B and Adenosine receptor A2b... 2 2
Transient receptor potential cation channel subfamily V member... 2 7
Adenosine receptor A3 ligand N-(4-methoxyphenyl)-2-oxo-1H-quin... 1 2
Arachidonate 5-lipoxygenase inhibitor ethyl (E)-3-(10H-phenoxa... 1 1
Matrix metalloproteinase-9 and Metalloproteinase inhibitor 3 i... 1 3
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 2 0
Glycogen synthase kinase-3 beta inhibitor 6-(4-fluorophenyl)-3... 1 0
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 1 1
Isoprenyl transferase inhibitor 2-benzyl-4-hydroxy-6-oxo-N-(4-... 1 0
NP (s)-3-(2,5-dioxo-2,3,4,5-tetrahydro-1h-benzo[e][1,4]diazepi... 3 0
N-(4-acetamidophenyl)-2-(2,2-dimethyl-3,4-dihydrochromen-6-yl)... 1 0
4-(4-methoxyphenyl)-2,4,5,10-tetrahydro-1H-pyrrolo[3,4-c][1,5]... 4 0
Putative NP ZINC04043041 Family 4 1
4-[(E)-3-(4-methoxyphenyl)prop-2-enoyl]-1-methyl-5,6,7,8-tetra... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00248926 CHEMBL2336357 Bioactive p'-cinnamanisidide
CFAMM00248939 DNC006021 Investigative Drug N-(4-methoxyphenyl)oleamide
CFAMM00248923 DNC006014 Investigative Drug (E)-N-(4-methoxyphenyl)undec-2-enamide
CFAMM00248921 DNC005565 Investigative Drug 2-Cyclohexyl-N-(4-methoxy-phenyl)-acetamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

22854 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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