CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1742
Family Name Oestrogen receptor and Estrogen receptor beta Ligand 6-(4-hydroxy-phenyl)-naphthalen-2-ol Family
No. of Seeds 30 No. of Other Members 63
Family Centroid CFAMM00249002 Functional Category Investigative Drug with Human Metabolite & Natural Product
Superfamily Tyrosinase and Oestrogen receptor Binder Superfamily
Class Class 2231

Cousin Family NamesSeedsMembers
D(2) dopamine receptor ligand catecholamine Dopamine family 9 170
Prostaglandin G/H synthase 2 Inhibitor Diflunisal Family 7 421
Opioid receptor ligand opiate Levorphanol Family 18 537
Oestrogen receptor ligand steroid Estradiol derivative Fulvest... 3 64
Muscarinic acetylcholine receptor M3 Ligand Tolterodine Family 8 171
Fatty-acid amide hydrolase 1 Inhibitor Propofol Family 5 428
Prostaglandin G/H synthase 2 Inhibitor Nabumetone Family 4 267
Signal transducer and activator of transcription 3 Inhibitor A... 5 249
Estrogen receptor beta Ligand Conjugated Estrogens Family 12 210
Tyrosinase Inhibitor Monobenzone Family 6 197
Oestrogen receptor ligand steroid Estradiol Family 18 147
Oestrogen receptor ligand Dienestrol Family 35 440
Oestrogen receptor Ligand Mestranol Family 2 29
Kappa-type opioid receptor Ligand Dezocine Family 36 46
Oestrogen receptor Ligand Lasofoxifene Family 19 152
Noradrenergic re-uptake Inhibitor Desvenalfaxine Succinate Family 2 4
Eptazocine Hbr family 6 8
Danthron family 11 141
Noradrenergic re-uptake and Opioid receptor Ligand Tapentadol ... 21 79
Sphingosine kinase 2 Inhibitor Phenoxodiol Family 24 682
NAD-dependent protein deacetylase sirtuin-1 Inhibitor SRT501 F... 19 88
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Muscarinic acetylcholine receptor M1 Ligand GSK1034702 Family 7 148
Urokinase-type plasminogen activator Inhibitor Amediplase Family 1 28
Multidrug resistance protein Inhibitor Curcumin I Family 19 278
TS-071 family 8 36
5-hydroxytryptamine receptor 1A Ligand (s)-uh-301 Family 35 20
Glucose-6-phosphate translocase Inhibitor Mumbaistatin Family 3 11
Bile acid receptor Ligand SR-45023A (apomine) Family 3 34
Estrogen receptor beta Ligand 1-chloro-6-(4-hydroxyphenyl)-2-n... 12 23
Glucocorticoid receptor Ligand 1-methoxy-6-phenyl-6h-benzo[c]c... 2 22
Abelson tyrosine-protein kinase 2 Inhibitor 3'',5''-dimethoxy-... 3 9
Oestrogen receptor and Estrogen receptor beta Ligand 1-bromo-6... 3 4
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 5 13
Arachidonate 15-lipoxygenase Inhibitor Hydrohalisulfate 1 Family 6 6
Cytochrome P450 2D6 Inhibitor Bs 7840 Family 4 9
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 214
NAD(P)H dehydrogenase [quinone] 1 Inhibitor NSC-106547 Family 3 65
Kinesin-like protein KIF11 Inhibitor 4'-(trifluoromethyl)-4-bi... 2 4
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 4-(1,... 3 31
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 4 37
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3-(6-hydroxy-2-nap... 7 9
5-hydroxytryptamine receptor 2A Ligand 3-methoxy-9-aminomethyl... 7 14
Androgen receptor Ligand 4-(m-tolyloxy)-2-(trifluoromethyl)ben... 7 65
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 5 8
Cannabinoid receptor 2 Ligand 2-(2-methoxybenzyl)-3h-benzo[f]c... 6 32
Arachidonate 12-lipoxygenase, 12S-type and Arachidonate 15-lip... 3 7
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
NAD(P)H dehydrogenase [quinone] 1 Inhibitor 4-hydroxy-3-(2-nap... 12 1
Indoleamine 2,3-dioxygenase 1 Inhibitor Naphthalene-1,4-diol F... 2 4
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 44 3
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 1 2
Tyrosinase Inhibitor 4-(6-hydroxynaphthalen-2-yl)benzene-1,3-d... 4 2
Tyrosinase Inhibitor 4-adamantyl Resorcinol Family 1 1
Vitamin D3 receptor ligand (3E,5E)-6-[3-[2-[3,4-bis(hydroxymet... 2 33
Vitamin D3 receptor ligand (3E,5E)-6-[3-[[3,4-bis(hydroxymethy... 2 4
Estrogen receptor beta and Estrogen receptor ligand (4Z)-2-flu... 2 0
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 2 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 14
Androgen receptor and Progesterone receptor ligand diarylpheno... 1 1
Sodium-dependent dopamine transporter and Sodium-dependent ser... 1 0
Arachidonate 5-lipoxygenase and Prostaglandin G/H synthase 1 i... 1 0
Steryl-sulfatase inhibitor (8R,9S,13S,14S,17R)-17-[(3-bromophe... 1 1
Steryl-sulfatase inhibitor (8R,9S,13S,14S,17R)-17-[(3,4-dichlo... 1 3
Aldo-keto reductase family 1 member C3 inhibitor (2R,8'R,9'S,1... 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 1-[3,... 4 0
Arachidonate 5-lipoxygenase and Prostaglandin G/H synthase 1 i... 1 3
Retinoic acid receptor beta ligand Adarotene family 1 0
Arachidonate 5-lipoxygenase and Prostaglandin G/H synthase 1 i... 1 3
Acenes Metabolite 2-Methyl-1,4-naphthalenediol bis(dihydrogen ... 2 2
Acenes Metabolite Lacinilene C Family 2 3
2,4-diacetyl-5-hydroxy-3-(4-hydroxyphenyl)-5-methylcyclohexen-... 4 0
[(E)-3-carboxy-2-(5-methyl-2-oxidophenyl)prop-2-enyl]-(2-pheny... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00249062 DNC005571 Investigative Drug 6-(2,5-Difluoro-4-hydroxy-phenyl)-naphthalen-2-ol
CFAMM00249005 DNC005587 Investigative Drug 6-Phenyl-naphthalen-2-ol
CFAMM00249023 DNC005601 Investigative Drug 1-Fluoro-6-(4-hydroxy-phenyl)-naphthalen-2-ol
CFAMM00249029 DNC009540 Investigative Drug 7-Hydroxy-3-(3-hydroxyphenyl)-1-naphthonitrile
CFAMM00249061 DNC005572 Investigative Drug 6-(2,6-Difluoro-4-hydroxy-phenyl)-naphthalen-2-ol
CFAMM00248973 DNC005590 Investigative Drug 7-Phenyl-naphthalen-2-ol
CFAMM00249004 DNC005586 Investigative Drug 6-(3-hydroxyphenyl)-2-naphthol
CFAMM00248972 DNC005591 Investigative Drug 4-Naphthalen-2-yl-phenol
CFAMM00249003 DNC005583 Investigative Drug 6-(3-Hydroxy-phenyl)-naphthalen-1-ol
CFAMM00249066 DNC005578 Investigative Drug 6-(3,5-Difluoro-4-hydroxy-phenyl)-naphthalen-2-ol
CFAMM00249027 DNC005606 Investigative Drug 6-(2-Fluoro-4-hydroxy-phenyl)-naphthalen-2-ol
CFAMM00249059 DNC009538 Investigative Drug 6-(3-Hydroxyphenyl)-1-phenyl-2-naphthol
CFAMM00249002 DNC005582 Investigative Drug 6-(4-Hydroxy-phenyl)-naphthalen-2-ol
CFAMM00249065 DNC005579 Investigative Drug 8-Fluoro-6-(4-hydroxy-phenyl)-naphthalen-2-ol
CFAMM00249026 DNC005602 Investigative Drug 6-(4-Hydroxy-phenyl)-1-phenyl-naphthalen-2-ol
CFAMM00249058 DNC009539 Investigative Drug 3-Hydroxy-7-(3-hydroxyphenyl)-1-naphthonitrile
CFAMM00249000 DNC005588 Investigative Drug 7-(4-Hydroxy-phenyl)-naphthalen-2-ol
CFAMM00248976 DNC008430 Investigative Drug 3-(2-naphthyl)phenol
CFAMM00249064 DNC005575 Investigative Drug 6-(4-Hydroxy-2-methyl-phenyl)-naphthalen-2-ol
CFAMM00249025 DNC005603 Investigative Drug 6-(4-Hydroxy-phenyl)-1-methyl-naphthalen-2-ol
CFAMM00249007 DNC005585 Investigative Drug 6-(2-Hydroxy-phenyl)-naphthalen-2-ol
CFAMM00249063 DNC005576 Investigative Drug 6-(3-Fluoro-4-hydroxy-phenyl)-naphthalen-2-ol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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