CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1743
Family Name Abelson tyrosine-protein kinase 2 Inhibitor 3'',5''-dimethoxy-[1,1';2',1'']-terphenyl-4-ol Family
No. of Seeds 3 No. of Other Members 9
Family Centroid CFAMM00249078 Functional Category Investigative Drug with Human Metabolite
Superfamily Neuraminidase and Androgen receptor Binder Superfamily
Class Class 605

Cousin Family NamesSeedsMembers
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Histamine H1 receptor Ligand Doxepin Family 8 89
Cannabinoid receptor 1 Ligand Marinol Family 32 454
Prostaglandin G/H synthase 2 Inhibitor Nabumetone Family 4 267
Signal transducer and activator of transcription 3 Inhibitor A... 5 249
Tyrosinase Inhibitor Monobenzone Family 6 197
Oestrogen receptor ligand Dienestrol Family 35 440
Oestrogen receptor Ligand Chlorotrianisene Family 2 102
D-alanyl-D-alanine carboxypeptidase Inhibitor B-lactams Family 59 1364
Oestrogen receptor Ligand Lasofoxifene Family 19 152
Ipriflavone family 62 2480
Rotenone family 16 107
Salicin family 5 629
Sodium/glucose cotransporter 2 Inhibitor Empagliflozin Family 32 52
Leukotriene B4 receptor 1 Ligand LY293111 Family 24 79
Sphingosine kinase 2 Inhibitor Phenoxodiol Family 24 682
NAD-dependent protein deacetylase sirtuin-1 Inhibitor SRT501 F... 19 88
Steryl-sulfatase Inhibitor Stx 64 Family 7 160
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Muscarinic acetylcholine receptor M1 Ligand GSK1034702 Family 7 148
Glucokinase Inhibitor R7201 Family 22 105
Translocator protein Inhibitor Dextofisopam Family 3 250
Multidrug resistance protein Inhibitor Curcumin I Family 19 278
Thyroid hormone receptor beta Ligand MB-07811 Family 1 2
Oxi4503 family 4 27
Acolbifene family 10 115
TS-071 family 8 36
Peroxisome proliferator-activated receptor gamma Ligand (2s)-2... 10 126
Arachidonate 15-lipoxygenase Inhibitor Isoscopoletin Family 5 98
Platelet-activating factor receptor Ligand L-652731 Family 5 116
Glucocorticoid receptor Ligand 1-methoxy-6-phenyl-6h-benzo[c]c... 2 22
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 7-(b... 4 42
Oestrogen receptor and Estrogen receptor beta Ligand 6-(4-hydr... 30 63
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 5 13
Arachidonate 15-lipoxygenase Inhibitor Hydrohalisulfate 1 Family 6 6
Oestrogen receptor and Estrogen receptor beta Ligand 3,8-dihyd... 20 57
Tubulin beta chain Inhibitor Combretastatin Family 3 5
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 214
NAD(P)H dehydrogenase [quinone] 1 Inhibitor NSC-106547 Family 3 65
Arachidonate 15-lipoxygenase and Arachidonate 5-lipoxygenase I... 3 18
Sodium/glucose cotransporter 2 Inhibitor Maackiain Family 1 5
Carbonic anhydrase 9 and Carbonic anhydrase 12 Inhibitor Ethox... 12 80
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 4-(1,... 3 31
Thyroid hormone receptor beta Ligand 2-hexylphenyl Acrylate Fa... 4 83
Kappa-type opioid receptor Ligand Anisocoumarin H Family 3 5
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 4 37
5-hydroxytryptamine receptor 2A Ligand 3-methoxy-9-aminomethyl... 7 14
Androgen receptor Ligand 2-methoxy-4-(o-tolyloxy)benzonitrile ... 5 12
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 2 12
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 5 8
MO15-related protein kinase Pfmrk Inhibitor WR-289012 Family 2 17
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 3-ben... 4 74
Cannabinoid receptor 2 Ligand 2-(2-methoxybenzyl)-3h-benzo[f]c... 6 32
Arachidonate 12-lipoxygenase, 12S-type and Arachidonate 15-lip... 2 1
Androgen receptor Ligand 2'-hydroxy-3-methoxy-biphenyl-4-carbo... 2 13
Cytochrome P450 3A4 Inhibitor (8r,8'r,9's)-5-methoxyclusin Family 6 20
Cytochrome P450 3A4 Inhibitor (-)-cubebininolide Family 4 28
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
NAD(P)H dehydrogenase [quinone] 1 Inhibitor Ethyl Bis(4-hydrox... 5 7
NAD(P)H dehydrogenase [quinone] 1 Inhibitor 4-hydroxy-3-(2-nap... 12 1
Indoleamine 2,3-dioxygenase 1 Inhibitor Naphthalene-1,4-diol F... 2 4
Amine oxidase [flavin-containing] B Inhibitor 7-fluoro-2-p-tol... 4 11
Tyrosine-protein phosphatase non-receptor type 1 and Neuramini... 10 2
Beta-secretase 1 Inhibitor Eckol Family 6 40
Epidermal growth factor receptor Ligand 3-(3-chloro-phenyl)-5,... 10 64
Prostaglandin G/H synthase 1 Inhibitor 2-(2-methoxyphenyl)-1h-... 1 11
Tyrosinase Inhibitor 4-(6-hydroxynaphthalen-2-yl)benzene-1,3-d... 4 2
Tyrosinase Inhibitor Kazinol S Family 1 0
Tyrosinase Inhibitor 4-adamantyl Resorcinol Family 1 1
Androgen receptor Ligand Palodesangren E Family 12 43
Sodium-dependent dopamine transporter Inhibitor Secocularidine... 3 9
Sodium/glucose cotransporter 2 and Sodium/glucose cotransporte... 3 19
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand [(6aR... 1 0
Melatonin receptor type 1A ligand N-[(7-methoxynaphthalen-1-yl... 1 0
Cannabinoid receptor 1 ligand 6,6,9-trimethyl-3-(6-nitrohex-2-... 1 0
Vitamin D3 receptor ligand (3E,5E)-6-[3-[[3,4-bis(hydroxymethy... 2 4
5-hydroxytryptamine receptor 7 and Alpha-2C adrenergic recepto... 3 0
Estrogen receptor beta and Estrogen receptor ligand SureCN4017... 3 5
Carbonic anhydrase 2 and Carbonic anhydrase 5A, mitochondrial ... 4 5
Vitamin D3 receptor ligand (1R,3S,5Z)-5-[(2E)-2-[(3aS,7aR)-1-[... 1 2
Steroidogenic factor 1 and Nuclear receptor subfamily 5 group ... 1 1
Geranylgeranyl pyrophosphate synthase inhibitor [1-Hydroxy-2-(... 1 2
Arachidonate 5-lipoxygenase inhibitor SureCN9727677 family 1 2
Arachidonate 5-lipoxygenase inhibitor AGN-PC-073G1D family 1 0
Cytochrome P450 1A1 and Cytochrome P450 1B1 inhibitor 1,2,4-tr... 1 0
Tyrosine-protein phosphatase non-receptor type 1 and Tyrosine-... 2 1
Arachidonate 5-lipoxygenase inhibitor AGN-PC-00PO2W family 1 1
Lignans and Norlignans Metabolite cis-Miyabenol C Family 3 0
Phenols and Derivatives Metabolite 2-Ethoxy-4-(4-methyl-1,3-di... 1 0
Benzene and Substituted Derivatives Metabolite 1,3,5-Trimethox... 2 17
2-(4-methoxyphenyl)-10,10-dimethyl-1,3,9-trioxaspiro[5.5]undec... 4 19
4-(9H-xanthen-9-yl)-9H-xanthene NP 9h,9'h-4,9'-bixanthene Family 1 0
Putative NP ZINC00526277 Family 2 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00249082 DNC006557 Investigative Drug 6-(3,5-dimethoxy-phenyl)-naphthalen-2-ol
CFAMM00249089 DNC005574 Investigative Drug 6-(4-Hydroxy-2-methoxy-phenyl)-naphthalen-2-ol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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