CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1749
Family Name Transient receptor potential cation channel subfamily V member 1 Ligand (e)-3-(4-tert-butyl-phenyl)-n-phenyl-acrylamide Family
No. of Seeds 6 No. of Other Members 33
Family Centroid CFAMM00249309 Functional Category Investigative Drug with Natural Product
Superfamily Pan-DAC Inhibitor AR-42 Superfamily
Class Class 1266

Cousin Family NamesSeedsMembers
D(2) dopamine receptor and D(3) dopamine receptor ligand indol... 4 123
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Sodium channel Ligand xylidine derivative Mepivacaine Family 10 114
Sodium channel Ligand iminostilbene derivative (tricyclic stru... 2 46
Noradrenergic re-uptake inhibitor Dibenzazepine Imipramine Family 8 178
Androgen receptor ligand aniline derivative Flutamide Family 3 9
Sodium channel protein type 5 subunit alpha Ligand Procainamid... 7 291
Voltage-gated sodium channel Ligand Oxcarbazepine Family 1 4
Cholesterol side-chain cleavage enzyme, mitochondrial and Arom... 9 26
Histone deacetylase 1 Inhibitor Vorinostat Family 26 138
Serum albumin Inhibitor Ebselen Family 3 62
3-hydroxy-3-methylglutaryl-coenzyme A reductase Inhibitor Simv... 4 27
Motilin receptor Ligand GSK962040 Family 30 457
Poly [ADP-ribose] polymerase 1 Inhibitor BSI-201 Family 3 16
Tumor necrosis factor Inhibitor Pirfenidone Family 2 38
Histone deacetylase 1 Inhibitor AN-9 Family 31 282
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
Pan-DAC Inhibitor AR-42 Family 21 153
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Delta-type opioid receptor Ligand Sb 227122 Family 7 5
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
Fumarate reductase flavoprotein subunit Inhibitor 2-heptyl-4-h... 3 16
Proto-oncogene tyrosine-protein kinase Src Inhibitor ISO24 Family 3 9
Urokinase-type plasminogen activator Inhibitor 6-(n-phenylcarb... 2 11
Liver carboxylesterase 1 Inhibitor 1-methyl-1h-indole-2,3-dion... 10 35
Tyrosine-protein phosphatase non-receptor type 1 Ligand [[4-(a... 1 7
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Glutamate receptor ionotropic, NMDA 2A and Glutamate receptor ... 14 78
Androgen receptor Ligand LG-121071 Family 8 32
Progesterone receptor Ligand 2,2,4-trimethyl-6-phenyl-1,2-dihy... 5 82
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 67
Aromatase Inhibitor 3-(4-amino-phenyl)-1-methyl-pyrrolidine-2,... 4 8
Histone Deacetylase 8 Inhibitor 6-(2-mercaptoacetamido)-n-phen... 4 8
Acetyl-CoA acetyltransferase, mitochondrial Inhibitor Octanoic... 4 14
Bifunctional epoxide hydrolase 2 Inhibitor N-(3-chloro-phenyl)... 2 43
Acetylcholinesterase Inhibitor Bw-28c51 Family 3 8
Aromatase Inhibitor 3-amino-4'-amino-trans-stilbene Family 5 47
Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibi... 1 9
Dual specificity mitogen-activated protein kinase kinase 1 Inh... 1 1
Androgen receptor Ligand 6-n-propyl -4-trifluoromethylquinolin... 29 13
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 3 26
Kinesin-like protein KIF11 Inhibitor N-[4'-(trifluoromethyl)-4... 7 134
Kinesin-like protein KIF11 Inhibitor N-[4'-(trifluoromethyl)-4... 2 9
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 1 16
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Oxysterols receptor LXR-alpha Ligand 2-(2-phenethylphenyl)isoi... 4 7
Transient receptor potential cation channel subfamily V member... 1 5
Progesterone receptor Ligand 3-(3,3-dimethyl-2-oxoindolin-5-yl... 2 10
Leukotriene A-4 hydrolase Inhibitor N5-[4-benzylphenyl]-l-glut... 2 1
Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... 4 21
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor Benz... 3 12
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 12
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-(... 2 17
Fatty-acid amide hydrolase 1 Inhibitor 1-biphenyl-4-ylmaleimid... 2 11
Neutrophil elastase Inhibitor 3-butyl-3-ethyl-1-phenylazetidin... 6 5
Metabotropic glutamate receptor 5 Ligand N-(3-acetamidophenyl)... 4 20
Cruzipain Inhibitor N1,n4-bis(5-chloro-2-methylphenyl)succinam... 1 5
Mitogen-activated protein kinase 14 Inhibitor Dihydro-quinolin... 3 14
DNA topoisomerase 1 Inhibitor 4-(4,6-diphenylpyridin-2-yl)phen... 1 1
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
Arachidonate 5-lipoxygenase and Prostaglandin G/H synthase 1 I... 9 7
Acetylcholinesterase Inhibitor (3-hydroxy-2-methyl-phenyl)-tri... 4 25
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 9h-bet... 1 1
Glutamate receptor ionotropic, NMDA 2A and Glutamate receptor ... 6 13
Aldose reductase Inhibitor (4-methyl-2-oxo-2h-quinolin-1-yl)-a... 1 15
Glutamate receptor ionotropic, NMDA 2A and Glutamate receptor ... 3 5
Glutamate receptor ionotropic, NMDA 2A and Glutamate receptor ... 8 3
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 15 129
5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)pip... 4 6
Tyrosinase Inhibitor S-2-(o-toluidino)-2-oxoethyl Carbamothioa... 1 1
Metabotropic glutamate receptor 5 Ligand 3-cyano-n-(3-cyanophe... 7 5
DNA topoisomerase Inhibitor 6-p-tolylamino-1h-pyrimidine-2,4-d... 3 17
DNA topoisomerase Inhibitor 6-(naphthalen-2-ylamino)-1h-pyrimi... 2 1
Dihydroorotate dehydrogenase Inhibitor N-(4-bromo-2-methylphen... 1 3
Myeloperoxidase Inhibitor 4-aminobenzoic Acid Hydrazide Family 1 3
Dihydroorotate dehydrogenase (quinone), mitochondrial and Dihy... 1 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 6
Ribosyldihydronicotinamide dehydrogenase [quinone] and Melaton... 1 3
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 1 0
D(4) dopamine receptor ligand 1-Piperidineacetamide, 4-(2-cyan... 3 7
Follicle-stimulating hormone receptor ligand AGN-PC-005HER family 5 2
Transient receptor potential cation channel subfamily V member... 1 1
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 3
Testosterone 17-beta-dehydrogenase 3 inhibitor SureCN4802053 f... 2 2
Tankyrase-2 inhibitor 7-(2-chlorophenyl)-4-methyl-1H-quinolin-... 1 1
5-hydroxytryptamine receptor 7 ligand 3-ethyl-3-[4-[4-(4-fluor... 3 1
5-hydroxytryptamine receptor 4 ligand 2-oxo-N-[(1R,5S)-8-(2-pi... 13 5
Retinal dehydrogenase 1 and Nuclear receptor ROR-gamma ligand ... 3 13
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 1 1
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 1 3
Progesterone receptor ligand AGN-PC-048NI9 family 1 5
Voltage-dependent L-type calcium channel subunit alpha-1S liga... 1 0
Metabotropic glutamate receptor 2 ligand 4-[4-(methylamino)phe... 1 4
Lysophosphatidic acid receptor 3 and Microtubule-associated pr... 1 1
Putative NP ZINC00209326 Family 4 0
3-prop-2-enyl-1H-quinolin-4-one NP 6-amino-2-methylquinolin-4-... 5 3
2-(6-methyl-2-oxo-4-phenyl-1H-quinolin-3-yl)acetate NP ZINC002... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00249318 CHEMBL1998736 Bioactive N-(2-Fluorophenyl)Cinnamamide
CFAMM00249338 CHEMBL1830129 Bioactive Cinnamanilide
CFAMM00249336 CHEMBL2336361 Bioactive (2e)-n-(4-fluorophenyl)-3-phenylacrylamide
CFAMM00249305 CHEMBL2336359 Bioactive (2e)-n-(4-methylphenyl)-3-phenylacrylamide
CFAMM00249304 CHEMBL2336358 Bioactive (E)-N-(2-methylphenyl)-3-phenylprop-2-enamide
CFAMM00249309 DNC005613 Investigative Drug (E)-3-(4-tert-Butyl-phenyl)-N-phenyl-acrylamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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