CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1754
Family Name Vascular endothelial growth factor receptor 1 and Vascular endothelial growth factor receptor 2 Ligand (2-methoxy-phenyl)-(5-phenyl-oxazol-2-yl)-amine Family
No. of Seeds 4 No. of Other Members 44
Family Centroid CFAMM00249476 Functional Category Investigative Drug
Superfamily Vascular endothelial growth factor receptor 1 and Vascular endothelial growth factor receptor 2 Binder Superfamily 2
Class Class 678

Cousin Family NamesSeedsMembers
Epidermal growth factor receptor and Receptor tyrosine-protein... 3 140
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 37
Melatonin receptor type 1B Ligand N-(3-benzooxazol-7-yl-propyl... 26 101
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 2-benzyl-6-... 9 80
Fatty-acid amide hydrolase 1 Inhibitor 1-(oxazolo[4,5-b]pyridi... 19 34
Vascular endothelial growth factor receptor 1 and Vascular end... 6 28
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
Neutrophil elastase Inhibitor Cbz-val-pro-val-(2-benzoxazole) ... 32 64
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Arachidonate 5-lipoxygenase Inhibitor 5-methyl-n-phenylbenzo[d... 5 13
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 5 25
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 4 5
Inosine-5'-monophosphate dehydrogenase 2 inhibitor [2-[N-methy... 1 18
Transient receptor potential cation channel subfamily V member... 7 5
5-hydroxytryptamine receptor 3A ligand 2-[(3S)-3-ethylmorpholi... 10 18
Prelamin-A/C inhibitor CHEMBL1374443 family 1 6
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 2
Adenosine receptor A2b and Adenosine receptor A2a ligand AGN-P... 2 0
Fatty-acid amide hydrolase 1 inhibitor 3-[(3R)-1-[4-(1-benzofu... 4 4
Vascular endothelial growth factor receptor 2 and Mast/stem ce... 8 8
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 5 12
Cannabinoid receptor 2 ligand [4-(5-tert-butyl-1,3-benzoxazol-... 4 1
Fatty-acid amide hydrolase 1 inhibitor 2-(1,3-dihydroisoindol-... 2 3
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 7
Prothrombin inhibitor SureCN6925359 family 6 18
Histamine H3 receptor ligand 2-(4-piperidin-1-ylpiperidin-1-yl... 1 3
Orexin receptor type 1 and Orexin receptor type 2 ligand [(2S,... 2 3
Tubulin beta-4A chain and Tubulin beta-2B chain inhibitor N-(2... 1 4
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-[4-(1,3-benzoxazol... 3 4
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 1 2
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 5 0
Integrin beta-1 and Integrin alpha-4 inhibitor 4-[[(2S,5S)-5-(... 20 10
Gamma-aminobutyric acid receptor subunit pi and Gamma-aminobut... 5 2
Mitogen-activated protein kinase 14 inhibitor 4-[4-(4-fluoroph... 1 5
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 6
Cathepsin S and Cathepsin L1 inhibitor (2S)-2-(1,3-benzoxazol-... 1 9
Cathepsin S and Cathepsin L1 inhibitor SureCN5361439 family 2 4
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 8 6
Integrin alpha-4 inhibitor (5R)-5-[[(2R)-2-[[2-[4-(1,3-benzoxa... 2 0
5-hydroxytryptamine receptor 6 ligand SureCN3910449 family 3 15
C-C chemokine receptor type 3 ligand SureCN6338683 family 1 2
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-077D0D family 3 0
Neuronal acetylcholine receptor subunit alpha-7 and 5-hydroxyt... 1 0
Vascular endothelial growth factor receptor 1 and Vascular end... 1 0
Diacylglycerol O-acyltransferase 1 inhibitor SureCN2789698 family 2 8
Vascular endothelial growth factor receptor 2 and Vascular end... 10 6
Inosine-5'-monophosphate dehydrogenase 2 inhibitor 7-methoxy-6... 7 0
Vascular endothelial growth factor receptor 2 and Vascular end... 4 1
Histamine H3 receptor ligand 9-[2-(4-piperidin-1-ylpiperidin-1... 1 3
Diacylglycerol O-acyltransferase 1 inhibitor 3-[[1-[5-[[2-(3-m... 1 1
Inosine-5'-monophosphate dehydrogenase 2 inhibitor AGN-PC-074D... 4 0
Inosine-5'-monophosphate dehydrogenase 2 inhibitor SureCN14736... 4 0
Inosine-5'-monophosphate dehydrogenase 2 inhibitor AC1LAY14 fa... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00249487 CHEMBL280793 Bioactive N-isoquinolin-6-yl-5-phenyl-1,3-oxazol-2-amine
CFAMM00249477 DNC005642 Investigative Drug (3-Phenoxy-phenyl)-(5-phenyl-oxazol-2-yl)-amine
CFAMM00249476 DNC005640 Investigative Drug (2-Methoxy-phenyl)-(5-phenyl-oxazol-2-yl)-amine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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