CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1755
Family Name Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacrine Heterodimer Family
No. of Seeds 43 No. of Other Members 17
Family Centroid CFAMM00249505 Functional Category Investigative Drug
Superfamily Cholinesterase and Acetylcholinesterase Binder Superfamily 3
Class Class 825

Cousin Family NamesSeedsMembers
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
Glutamate dehydrogenase inhibitor quinoline derivative Chloroq... 7 189
Histamine H1 receptor ligand tricyclic antidepressant Deslorat... 6 136
Acetylcholinesterase Inhibitor Tacrine Family 12 515
D(2) dopamine receptor Ligand Sertindole Family 3 173
Histamine H1 receptor Ligand Triprolidine Family 19 316
Sarcoplasmic/endoplasmic reticulum calcium ATPase inhibitor qu... 2 60
Neuromedin-K receptor Ligand SB222200 Family 17 235
Glucagon receptor Ligand Dwlip-gcgrrx Family 5 26
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
D(1B) dopamine receptor Ligand LE-300 Family 65 452
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
Nicotinic acetylcholine receptor Ligand Epibatidine Family 36 19
Lethal factor Inhibitor N,n'-bis(4-amino-2-methylquinolin-6-yl... 2 11
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 32
D(2) dopamine receptor and D(3) dopamine receptor Ligand L-741... 9 73
Potassium voltage-gated channel subfamily H member 2 Ligand 5-... 5 14
5-hydroxytryptamine receptor 2A Ligand 8-chloro-1,2,3,4-tetrah... 5 4
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
Acetylcholinesterase and Cholinesterase Inhibitor Lipocrine Fa... 18 36
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
Canalicular multispecific organic anion transporter 1 Inhibito... 7 5
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Urotensin-2 receptor Ligand Palosuran Family 4 4
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 10 18
Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... 5 35
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Metabotropic glutamate receptor 5 Ligand 3-fluoro-5-(2-methylq... 3 2
Metabotropic glutamate receptor 5 Ligand 3-chloro-5-(2-methylq... 3 4
Metabotropic glutamate receptor 5 Ligand 7-m-tolyl-1,6-naphthy... 4 2
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 1 0
Protein kinase C alpha type Inhibitor Dequalinium Analogue Family 1 10
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 2 1 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 3
5-hydroxytryptamine receptor 1A and D(1A) dopamine receptor li... 2 3
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074YYL... 1 3
Corticotropin-releasing factor receptor 1 ligand N-(cyclopropy... 2 2
D(4) dopamine receptor and D(1A) dopamine receptor ligand 2-[[... 5 4
Prostaglandin G/H synthase 2 inhibitor SureCN6998947 family 1 1
Melatonin receptor type 1A and Melatonin receptor type 1C liga... 2 5
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 5 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 9 3
Dipeptidyl peptidase 4 inhibitor AGN-PC-09QKOM family 5 8
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 3 3
Glucocorticoid receptor and Androgen receptor ligand AGN-PC-0A... 3 0
Melanin-concentrating hormone receptor 2 and Sodium-dependent ... 2 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 0
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-009GH... 8 10
Melanin-concentrating hormone receptor 1 and 5-hydroxytryptami... 2 0
Melanin-concentrating hormone receptor 1 ligand SureCN4261878 ... 4 7
Melanin-concentrating hormone receptor 1 ligand SureCN6198980 ... 13 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand 6-(2-... 1 2
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 0
Gamma-aminobutyric acid receptor subunit beta-3 and Gamma-amin... 2 5
Cannabinoid receptor 1 ligand AGN-PC-07R6NY family 2 0
Corticotropin-releasing factor receptor 1 ligand 2-(2,4-dichlo... 2 2
D(2) dopamine receptor and D(3) dopamine receptor ligand methy... 2 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Glucagon receptor and Mitogen-activated protein kinase 14 liga... 1 1
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 2
Nociceptin receptor ligand AGN-PC-07C3R0 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00249536 CHEMBL2393095 Bioactive N'-(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)nonane-1,9-diamine
CFAMM00249513 CHEMBL2393100 Bioactive 6-chloro-N-octyl-1,2,3,4-tetrahydroacridin-9-amine
CFAMM00249535 CHEMBL2393094 Bioactive N'-(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)octane-1,8-diamine
CFAMM00249512 CHEMBL574973 Bioactive AGN-PC-07CNTW
CFAMM00249500 CHEMBL538573 Bioactive AGN-PC-009HFD
CFAMM00249518 CHEMBL2007996 Bioactive NCI60_041179
CFAMM00249534 CHEMBL2393097 Bioactive N'-(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)dodecane-1,12-diamine
CFAMM00249540 CHEMBL555666 Bioactive AGN-PC-046PQY
CFAMM00249499 CHEMBL483716 Bioactive 3-CHLORO-9-ETHYL-6,7,8,9,10,11-HEXAHYDRO-7,11-METHANOCYCLOOCTA[B]QUINOLIN-12-AMINE
CFAMM00249517 CHEMBL539599 Bioactive AGN-PC-00A5WB
CFAMM00249533 CHEMBL2393096 Bioactive N'-(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)decane-1,10-diamine
CFAMM00249539 CHEMBL583920 Bioactive AGN-PC-07CNUE
CFAMM00249509 CHEMBL534932 Bioactive CHEMBL534932
CFAMM00249538 CHEMBL2393093 Bioactive N'-(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)heptane-1,7-diamine
CFAMM00249515 CHEMBL2393102 Bioactive 6-chloro-N-decyl-1,2,3,4-tetrahydroacridin-9-amine
CFAMM00249537 CHEMBL2393092 Bioactive N'-(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)hexane-1,6-diamine
CFAMM00249521 CHEMBL1994202 Bioactive CHEMBL1994202
CFAMM00249496 CHEMBL557155 Bioactive AGN-PC-008KLC
CFAMM00249514 CHEMBL2393101 Bioactive 6-chloro-N-nonyl-1,2,3,4-tetrahydroacridin-9-amine
CFAMM00249530 CHEMBL573095 Bioactive AGN-PC-0739NJ
CFAMM00249526 DNC005658 Investigative Drug (+/-)-huprineY hydrochloride
CFAMM00249516 DNC009923 Investigative Drug Huprine Y
CFAMM00249508 DNC006634 Investigative Drug huprine X

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26391 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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