CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1771
Family Name Cathepsin B and Cathepsin K Inhibitor L-006235-1 Family
No. of Seeds 19 No. of Other Members 75
Family Centroid CFAMM00250158 Functional Category Investigative Drug with Natural Product
Superfamily Cathepsin B and Cathepsin K Inhibitor L-006235-1 Superfamily
Class Class 804

Cousin Family NamesSeedsMembers
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 7-me... 2 45
Metabotropic glutamate receptor 5 Ligand 3-chloro-n-(4-methylt... 2 12
Histone deacetylase 1 and Histone deacetylase 4 Inhibitor 7-me... 3 14
Arachidonate 5-lipoxygenase Inhibitor N-(thiazol-2-yl)benzamid... 3 53
Arachidonate 5-lipoxygenase Inhibitor 2-phenyl-n-(thiazol-2-yl... 3 27
Cyclin-dependent kinase 5 Inhibitor 3-(2-phenylthiazol-4-yl)qu... 2 44
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 4 3
Mitogen-activated protein kinase 11 and Mitogen-activated prot... 10 31
Adenosine receptor A1 Ligand N-(4-phenyl-thiazol-2-yl)-benzami... 5 2
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-264... 6 32
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(5-b... 3 9
Adenosine receptor A1 Ligand 4-chloro-n-(4-phenyl-thiazol-2-yl... 4 2
Adenosine receptor A1 Ligand 4-nitro-n-(4-phenyl-thiazol-2-yl)... 2 38
Substance-K receptor and Substance-P receptor ligand N-[4-[[4-... 1 0
Cathepsin K inhibitor N-[1-[[(2S,3S)-2-ethyl-4-oxooxolan-3-yl]... 1 0
Histone deacetylase 1 and Histone deacetylase 2 inhibitor AGN-... 2 5
Neuropeptide Y receptor type 5 ligand 2-phenyl-1-[(1R,5S)-6-[[... 9 11
Prothrombin inhibitor (2S)-N-[(4-carbamimidoyl-1,3-thiazol-2-y... 3 2
Thyroid hormone receptor beta and Ferritin light chain ligand ... 3 10
Cathepsin K and Cathepsin S inhibitor N-[1-(cyanomethylcarbamo... 2 1
Protease and Capsid scaffolding protein inhibitor AC1LAC7K family 2 5
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 13
Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-3-... 2 1
Neuropeptide Y receptor type 5 ligand N-[5-[(9-fluoro-5,6-dihy... 7 7
Neuronal acetylcholine receptor subunit alpha-7 ligand AGN-PC-... 7 1
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 9 16
Mitogen-activated protein kinase 14 inhibitor N-[4-[2-ETHYL-4-... 4 5
Orexin receptor type 2 and Orexin receptor type 1 ligand (2-me... 3 1
Serine/threonine-protein kinase Chk1 inhibitor 2-(1H-indol-5-y... 2 2
Serine/threonine-protein kinase Chk1 inhibitor 2-(1-benzothiop... 4 6
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-[4-(4-phenyl-1,3-t... 3 4
Cathepsin K and Cathepsin S inhibitor (1R,2R)-2-[4-(1,3-benzot... 1 4
Cathepsin K and Cathepsin L1 inhibitor (2R)-N-(cyanomethyl)-4-... 2 1
D(3) dopamine receptor and D(2) dopamine receptor ligand [4-[2... 5 5
D(3) dopamine receptor and D(2) dopamine receptor ligand [4-[2... 6 5
Cholinesterase and Acetylcholinesterase inhibitor 3-[ethyl-[3-... 6 9
D(4) dopamine receptor ligand Benzamide, 3-methyl-N-[[4-(2-thi... 2 1
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 8 1
C-C chemokine receptor type 2 ligand N-[[3,5-bis(trifluorometh... 22 16
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 5 activa... 4 4
Serine/threonine-protein kinase Chk1 inhibitor 2-(1,3-dihydroi... 2 5
MAP kinase-activated protein kinase 2 inhibitor 2-[(4,4-dimeth... 11 11
Glycylpeptide N-tetradecanoyltransferase inhibitor N-[2-(2-met... 5 8
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 10
Neuropeptide Y receptor type 5 ligand 2-(dimethylamino)-1-[4-[... 10 5
Neuropeptide Y receptor type 5 ligand 1-[4-[[(9-fluoro-5,6-dih... 11 0
C-C chemokine receptor type 2 ligand AGN-PC-0765RZ family 1 0
5-hydroxytryptamine receptor 2A ligand 4-[(3R)-3-[2-amino-4-(4... 1 0
Neuropeptide Y receptor type 5 ligand 1-[4-[[(9-chloro-5,6-dih... 1 0
Integrin beta-3 and Integrin alpha-IIb inhibitor 4-[[4-(4-carb... 4 2
Proto-oncogene tyrosine-protein kinase LCK and Tyrosine-protei... 3 9
Coagulation factor X inhibitor AGN-PC-09QNAS family 2 1
Prothrombin and Trypsin-1 inhibitor (2S)-1-[(2R)-2-amino-3,3-d... 1 3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Protein-cysteine N-palmitoyltransferase porcupine inhibitor N-... 3 1
D(2) dopamine receptor and Potassium voltage-gated channel sub... 2 0
Extracellular calcium-sensing receptor ligand 2-[[3,3-diphenyl... 2 2
Extracellular calcium-sensing receptor ligand 3-(1,3-benzothia... 5 1
Metabotropic glutamate receptor 5 ligand N-[(2R)-3-hydroxy-3-m... 1 0
Poly [ADP-ribose] polymerase 1 inhibitor CHEMBL246396 family 22 0
Glucagon receptor and Gastric inhibitory polypeptide receptor ... 2 13
Glucagon receptor and Gastric inhibitory polypeptide receptor ... 5 2
Glucagon receptor and Gastric inhibitory polypeptide receptor ... 5 3
Coagulation factor X and Prothrombin inhibitor AGN-PC-069H7M f... 2 0
Nuclear receptor ROR-gamma and Prelamin-A/C ligand CHEMBL13846... 1 0
Coagulation factor X inhibitor 2,4-dimethyl-N-[N-(3-methylphen... 1 1
Histone deacetylase 6 inhibitor ethyl 2-[[(2S)-2-(phenylmethox... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00250172 CHEMBL200287 Bioactive N-[1-(cyanomethylcarbamoyl)cyclohexyl]-4-[2-[4-(propan-2-ylamino)piperidin-1-yl]-1,3-thiazol-4-yl]benzamide
CFAMM00250083 CHEMBL199358 Bioactive N-[1-(cyanomethylcarbamoyl)cyclohexyl]-4-(2-morpholin-4-yl-1,3-thiazol-4-yl)benzamide
CFAMM00250101 CHEMBL200455 Bioactive N-[1-(cyanomethylcarbamoyl)cyclohexyl]-4-[2-(1-methylpiperidin-4-yl)-1,3-thiazol-4-yl]benzamide
CFAMM00250183 CHEMBL200602 Bioactive N-[1-(cyanomethylcarbamoyl)cyclohexyl]-4-[2-[4-(2-methoxyethyl)piperazin-1-yl]-1,3-thiazol-4-yl]benzamide
CFAMM00250134 CHEMBL199470 Bioactive N-[1-(cyanomethylcarbamoyl)cyclohexyl]-4-[2-[3-(dimethylamino)pyrrolidin-1-yl]-1,3-thiazol-4-yl]benzamide
CFAMM00250153 CHEMBL212907 Bioactive N-(cyanomethyl)-4-methyl-2-[3-[3-(2-piperazin-1-yl-1,3-thiazol-4-yl)phenyl]phenyl]pentanamide
CFAMM00250141 CHEMBL200507 Bioactive 4-[2-[(3R)-3-aminopyrrolidin-1-yl]-1,3-thiazol-4-yl]-N-[1-(cyanomethylcarbamoyl)cyclohexyl]benzamide
CFAMM00250064 CHEMBL213930 Bioactive N-(cyanomethyl)-4-methyl-2-[3-[3-[2-(4-methylpiperazin-1-yl)-1,3-thiazol-4-yl]phenyl]phenyl]pentanamide
CFAMM00250168 CHEMBL198798 Bioactive N-[1-(cyanomethylcarbamoyl)cyclohexyl]-4-[2-(4-piperidin-1-ylpiperidin-1-yl)-1,3-thiazol-4-yl]benzamide
CFAMM00250140 CHEMBL200506 Bioactive N-[1-(cyanomethylcarbamoyl)cyclohexyl]-4-[2-[(4-methylpiperazin-1-yl)methyl]-1,3-thiazol-4-yl]benzamide
CFAMM00250061 CHEMBL200543 Bioactive N-[1-(cyanomethylcarbamoyl)cyclohexyl]-4-[2-[4-(oxan-4-yl)piperazin-1-yl]-1,3-thiazol-4-yl]benzamide
CFAMM00250167 CHEMBL200166 Bioactive N-[1-(cyanomethylcarbamoyl)cyclohexyl]-4-[2-(1,4-dimethylpiperidin-4-yl)-1,3-thiazol-4-yl]benzamide
CFAMM00250058 CHEMBL414669 Bioactive N-[1-(cyanomethylcarbamoyl)cyclohexyl]-4-[2-[methyl-(4-methylpiperazin-1-yl)amino]-1,3-thiazol-4-yl]benzamide
CFAMM00250194 CHEMBL211737 Bioactive AGN-PC-0764AM
CFAMM00250102 CHEMBL200708 Bioactive 4-[2-(4-tert-butylpiperazin-1-yl)-1,3-thiazol-4-yl]-N-[1-(cyanomethylcarbamoyl)cyclohexyl]benzamide
CFAMM00250173 CHEMBL212879 Bioactive (2R)-2-[3-[3-[2-(4-tert-butylpiperazin-1-yl)-1,3-thiazol-4-yl]phenyl]phenyl]-N-(cyanomethyl)-4-methylpentanamide
CFAMM00250055 CHEMBL200494 Bioactive AGN-PC-00DOGC
CFAMM00250125 CHEMBL200596 Bioactive N-[1-(cyanomethylcarbamoyl)cyclohexyl]-4-[2-[4-[methyl(propan-2-yl)amino]piperidin-1-yl]-1,3-thiazol-4-yl]benzamide
CFAMM00250158 DNC005713 Investigative Drug L-006235-1

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27512 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543