CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1772
Family Name Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-(naphthalen-2-yl)pyridine Family
No. of Seeds 14 No. of Other Members 22
Family Centroid CFAMM00250241 Functional Category Investigative Drug
Superfamily Cytochrome P450 11B1, mitochondrial and Aromatase Binder Superfamily
Class Class 2102

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
Histamine H1 receptor ligand tricyclic antidepressant Loratadi... 5 163
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Amrino... 3 55
Glutamate dehydrogenase inhibitor quinoline derivative Chloroq... 7 189
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
Neuronal acetylcholine receptor subunit alpha-4 Ligand Varenic... 3 54
Histamine H1 receptor ligand tricyclic antidepressant Deslorat... 6 136
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapone Family 9 243
Thromboxane A2 receptor Ligand Ridogrel Family 7 83
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Acetylcholinesterase Inhibitor Tacrine Family 12 515
Farnesyl pyrophosphate synthase Inhibitor Risedronate Family 4 28
Prostaglandin G/H synthase 2 Inhibitor Etoricoxib Family 2 99
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor Ethion... 5 68
Histamine H1 receptor Ligand (s)-(+)-dimethindene Maleate Family 6 12
SUR2-type K(ATP) channel Ligand Nicorandil Family 5 85
Sarcoplasmic/endoplasmic reticulum calcium ATPase inhibitor qu... 2 60
Prothrombin Inhibitor Ximelegatran Family 8 157
G protein-activated inward rectifier potassium channel 4 Ligan... 3 48
Thromboxane A2 receptor Ligand Bibv 308 Family 14 40
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
D(1B) dopamine receptor Ligand LE-300 Family 65 452
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Amg 423 family 7 47
ABC294640 family 5 75
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Nicotinic acetylcholine receptor Ligand Epibatidine Family 36 19
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 6 17
Carbonic anhydrase 2 Inhibitor Cyanamide Family 2 32
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Aromatase Inhibitor Rogletimide Family 1 2
Platelet-derived growth factor receptor alpha and Platelet-der... 5 48
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor Cycl... 1 0
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 19
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 22
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 3 5
Plasminogen and Tissue-type plasminogen activator Inhibitor N-... 1 5
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 2 11
Cytochrome P450 3A4 Inhibitor 3-(3-methylthiophen-2-yl)pyridin... 5 27
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 16
Cytochrome P450 11B1, mitochondrial Inhibitor 3-(6-bromo-napht... 1 1
Metabotropic glutamate receptor 5 Ligand 2-m-tolyl-1,8-naphthy... 7 11
DNA-dependent protein kinase catalytic subunit Inhibitor 2-mor... 2 6
Metabotropic glutamate receptor 5 Ligand 2-methyl-6-(4-phenylb... 6 32
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
D(2) dopamine receptor and D(3) dopamine receptor Ligand 1-(4-... 10 48
Transient receptor potential cation channel subfamily V member... 6 23
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 37 1
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Trypsin Inhibitor 1-benzyl-1h-indole-5-carboxamidine Family 4 3
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
Farnesyl pyrophosphate synthase Inhibitor Piridronic Acid Family 3 14
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Hepatocyte growth factor receptor Ligand 1-benzyl-1h-pyrrolo[3... 2 16
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Hydroxycarboxylic acid receptor 2 Ligand 2-(6-phenylhexyl)pyri... 4 11
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Acetylcholinesterase and Cholinesterase Inhibitor 1,9-bis(pyri... 8 38
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Prostaglandin G/H synthase 1 Inhibitor 1-(4-aminosulfonylpheny... 3 18
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Cathepsin S Inhibitor 6-(3-(trifluoromethyl)phenyl)picolinonit... 7 2
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
Cathepsin L1 Inhibitor (3-bromobenzoylpyridine)thiosemicarbazo... 1 0
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 1 3
Reverse transcriptase Inhibitor PT-102 Family 8 12
Cytochrome P450 11B1, mitochondrial Inhibitor 2-methyl-1,2-di-... 8 15
Translocator protein Inhibitor 5-phenyl-6-thia-10b-aza-benzo[e... 1 2
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Reverse transcriptase Inhibitor PT-109 Family 6 7
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 6
Metabotropic glutamate receptor 5 Ligand 5-(2-methylquinolin-7... 4 3
Metabotropic glutamate receptor 5 Ligand 3-fluoro-5-(2-methylq... 3 2
Metabotropic glutamate receptor 5 Ligand 7-m-tolyl-1,6-naphthy... 4 2
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Acetylcholinesterase and Cholinesterase Inhibitor 7-oxo-7h-dib... 2 3
Metabotropic glutamate receptor 1 Ligand (e)-4,4-dimethyl-1-qu... 2 2
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Tyrosinase Inhibitor 5-(pyridin-4-yl)-1,3,4-thiadiazole-2(3h)-... 1 1
Protein kinase C alpha type Inhibitor Dequalinium Analogue Family 1 10
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 2 1 2
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 1 13
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 3
Histamine H1 receptor and Potassium voltage-gated channel subf... 5 5
Progesterone receptor and Androgen receptor ligand 5-[4-[(Z)-C... 2 5
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 1
Thromboxane-A synthase and Thromboxane A2 receptor ligand (E)-... 2 1
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 1 1
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor 4-[2-(... 2 6
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 1 1
Hepatocyte growth factor receptor ligand AGN-PC-08XYH3 family 1 0
Metabotropic glutamate receptor 5 ligand AGN-PC-0A9SQ6 family 3 0
Geranylgeranyl pyrophosphate synthase and Farnesyl pyrophospha... 1 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 0
Glucocorticoid receptor ligand 1,1,1-trifluoro-2-[(1-methyl-3,... 3 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 1 4
D(4) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 1
Beta-secretase 1 and Potassium voltage-gated channel subfamily... 3 4
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 8 0
Neuronal acetylcholine receptor subunit alpha-6 ligand AGN-PC-... 2 0
G-protein coupled bile acid receptor 1 ligand 1-[4-[(1R,3E)-1-... 1 1
Progesterone receptor ligand (8S,11R,13S,14S,16R,17S)-17-(cycl... 11 0
Thromboxane-A synthase inhibitor 7-[(2S,3R)-3-pyridin-3-yl-2-b... 1 1
Platelet-activating factor receptor ligand SureCN9853140 family 3 3
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 5
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 10 1
Neuropeptide Y receptor type 5 ligand SureCN4464548 family 17 2
Neuronal acetylcholine receptor subunit alpha-6 ligand AGN-PC-... 1 0
Thromboxane-A synthase inhibitor (Z)-2-bromo-3-[4-(pyridin-3-y... 1 0
Nociceptin receptor and Mu-type opioid receptor ligand (1S,5S)... 1 0
Thymidylate synthase inhibitor AGN-PC-00EUGY family 2 7
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 2
Histamine H3 receptor ligand AGN-PC-09M6FC family 1 9
Beta-secretase 2 and Beta-secretase 1 inhibitor 2-cyclopropyl-... 1 1
Potassium voltage-gated channel subfamily A member 5 and Inter... 1 0
Prelamin-A/C and Excitatory amino acid transporter 1 inhibitor... 1 0
Tyrosyl-DNA phosphodiesterase 1 and Inositol monophosphatase 1... 1 3
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 1 0
Glycogen synthase kinase-3 beta inhibitor 3-naphthalen-1-yl-2-... 1 0
Farnesyl pyrophosphate synthase inhibitor [[(5-benzylpyridin-3... 1 0
Potassium voltage-gated channel subfamily A member 5 and Inter... 2 0
Potassium voltage-gated channel subfamily H member 2 ligand 1-... 1 0
Cytochrome P450 3A4 inhibitor N-[2-fluoro-4-(4-fluorophenyl)ph... 2 1
Neuronal acetylcholine receptor subunit alpha-3 and Neuronal a... 1 5
Kinesin-like protein KIF11 inhibitor AGN-PC-077SFB family 1 0
Pyridines and Derivatives Metabolite (S)-Actinidine Family 1 0
Pyridines and Derivatives Metabolite Rotundine A Family 1 0
NP 3-((1-(3-(2-(pyridin-3-yl)piperidin-1-yl)prop-1-yn-1-yl)cyc... 12 0
Putative NP ZINC38570085 Family 14 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00250210 CHEMBL524011 Bioactive AGN-PC-04WVL1
CFAMM00250227 DNC009633 Investigative Drug 3-(5,6,7,8-Tetrahydronaphthalen-2-yl)pyridine
CFAMM00250233 DNC005725 Investigative Drug 3-Phenanthren-9-yl-pyridine
CFAMM00250209 DNC008929 Investigative Drug 3-(3-Benzylnaphthalen-2-yl)pyridine
CFAMM00250207 DNC006004 Investigative Drug 3-(1,2-dihydroacenaphthylen-5-yl)pyridine
CFAMM00250241 DNC005714 Investigative Drug 3-(naphthalen-2-yl)pyridine
CFAMM00250206 DNC006003 Investigative Drug 3-(1,2-dihydroacenaphthylen-3-yl)pyridine
CFAMM00250240 DNC005719 Investigative Drug 6-(pyridin-3-yl)-2-naphthonitrile
CFAMM00250205 DNC008621 Investigative Drug 6-(4-Methylpyridin-3-yl)-2-naphthonitrile

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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