Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database. Cousin Family Names Seeds Members Histamine H1 receptor Ligand Doxylamine Family 2 91 Aromatic-L-amino-acid decarboxylase Inhibitor Vitamin B6 Family 6 13 cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741 Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265 Citric Acid family 2 58 Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97 5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115 Reverse transcriptase Inhibitor 3'thiacytidine Family 4 29 Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48 Hemoglobin subunit alpha Inhibitor 4-[(5-methoxy-2-methylpheno... 3 12 Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 5 23 Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34 Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3 Adenosine receptor A3 Ligand 4-methoxy-2-phenyl-2h-pyrazolo[4,... 9 49 Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6 Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 2 5 Macrophage migration inhibitory factor Inhibitor 4-((pyridin-4... 1 0 Oestrogen receptor and Estrogen receptor beta Ligand Estrogen ... 7 2 5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35 RAF proto-oncogene serine/threonine-protein kinase Inhibitor 5... 3 7 Cytochrome P450 11B1, mitochondrial Inhibitor 5-(6-methoxynaph... 7 4 Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... 4 5 Estradiol 17-beta-dehydrogenase 1 Inhibitor 3,3'-pyrazine-2,5-... 2 14 Indoleamine 2,3-dioxygenase 1 Inhibitor 5-aminoquinolin-8-ol F... 3 16 Potassium voltage-gated channel subfamily A member 5 Ligand 2-... 5 69 DNA topoisomerase 1 Inhibitor 3-(4-phenyl-2,4'-bipyridin-6-yl)... 4 13 Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapol Family 3 41 Delta-type opioid receptor and Kappa-type opioid receptor Liga... 38 35 Androgen receptor Ligand 11-methyl-6,11-dihydro-5h-benzo[a]car... 7 9 Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20 Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7 Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 8 10 cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 1 Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 3 18 Serine/threonine-protein kinase B-raf inhibitor AGN-PC-00CFYH ... 2 1 Cyclin-dependent kinase 4 and Cyclin-dependent kinase 2 inhibi... 3 1 Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-... 1 0 D(4) dopamine receptor ligand AGN-PC-00SXAZ family 2 4 Serine/threonine-protein kinase Chk1 inhibitor SureCN6786541 f... 3 6 D(1A) dopamine receptor and D(2) dopamine receptor ligand (6aR... 3 6 Estrogen receptor and Estrogen receptor beta ligand SureCN6841... 2 5 Glucocorticoid receptor ligand SureCN3894124 family 3 0 Nociceptin receptor and Potassium voltage-gated channel subfam... 3 9 Beta-3 adrenergic receptor ligand N-[4-[2-[[(2R)-2-hydroxy-2-p... 4 10 D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 2 D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 7 1 Glutamate receptor ionotropic, NMDA 2B ligand SureCN8345160 fa... 1 2 Sodium/hydrogen exchanger 1 inhibitor 2-[(E)-[7-(2-chloropheny... 2 0 Retinoic acid receptor RXR-alpha and Retinoic acid receptor RX... 1 0 cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 2 4 Nuclear receptor ROR-gamma and Induced myeloid leukemia cell d... 1 1 Acetylcholinesterase inhibitor 1,8-dihydroxy-3-(pyridin-1-ium-... 1 0 Cytochrome P450 11B2, mitochondrial and Steroid 17-alpha-hydro... 1 0 Estrogen receptor and Estrogen receptor beta ligand AGN-PC-074... 1 0 Urokinase-type plasminogen activator and Plasminogen inhibitor... 1 0 Aromatase inhibitor AGN-PC-075MRV family 1 3 Arachidonate 15-lipoxygenase and Arachidonate 15-lipoxygenase ... 1 0 Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 1 0 Pyridines and Derivatives Metabolite 4-Hydroxy-4-(3-pyridyl)-b... 1 2 (4-methoxyphenyl)-[(2R)-2-pyridin-3-ylpiperidin-1-yl]phosphina... 1 0 (E)-3-(2-hydroxyphenyl)-1-pyridin-4-ylprop-2-en-1-one NP (e)-3... 1 0
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAMM00250280 CHEMBL77680 Bioactive
CHEMBL77680 CFAMM00250287 CHEMBL93828 Bioactive
5-hydroxy-2-(pyridin-4-ylmethyl)-3,4-dihydro-2H-naphthalen-1-one CFAMM00250264 CHEMBL55217 Bioactive
2,6-dimethyl-4-[(E)-2-pyridin-3-ylethenyl]phenol CFAMM00250272 CHEMBL293821 Bioactive
SureCN10385357 CFAMM00250278 CHEMBL338169 Bioactive
(E)-3-(3,4-dihydroxyphenyl)-1-(2-pyridin-3-ylphenyl)prop-2-en-1-one CFAMM00250277 CHEMBL496262 Bioactive
Abiraterone mimetic, 6 CFAMM00250291 CHEMBL404601 Bioactive
4-[1-[2-(4-bromophenyl)prop-2-enyl]pyridin-1-ium-4-yl]phenol;bromide CFAMM00250290 CHEMBL294003 Bioactive
2,6-diethyl-4-[(E)-2-pyridin-3-ylethenyl]phenol CFAMM00250253 CHEMBL28054 Bioactive
(6aR,12bS)-5,6,6a,7,8,12b-hexahydronaphtho[2,1-c][2,6]naphthyridine-10,11-diol CFAMM00250281 CHEMBL414824 Bioactive
1,6-Bpep CFAMM00250274 CHEMBL2420678 Bioactive
8-chloro-1-fluoro-7-pyridin-3-ylnaphthalen-2-ol CFAMM00250288 CHEMBL2420680 Bioactive
8-chloro-7-(5-fluoropyridin-3-yl)naphthalen-2-ol CFAMM00250271 CHEMBL2420688 Bioactive
8-chloro-7-isoquinolin-4-ylnaphthalen-2-ol CFAMM00250275 CHEMBL2420674 Bioactive
8-chloro-7-pyridin-3-ylnaphthalen-2-ol CFAMM00250252 CHEMBL322004 Bioactive
3-[(E)-1,1,1-trifluoro-4-phenyl-2-phenylmethoxybut-3-en-2-yl]-1H-pyridin-2-one CFAMM00250268 CHEMBL2420684 Bioactive
5-(1-chloro-7-hydroxynaphthalen-2-yl)pyridin-3-ol CFAMM00250249 HMDB30347 Human Metabolite
N-(p-Hydroxyphenethyl)actinidine CFAMM00250270 HMDB33483 Human Metabolite
6,7-Dihydro-4-(hydroxymethyl)-2-(p-hydroxyphenethyl)-7-methyl-5H-2-pyrindinium CFAMM00250265 ZINC20112723 Natural Product
(2S)-2-(2-hydroxyphenyl)-2-[(2R)-2-pyridin-3-ylpiperidin-1-yl]acetonitrile CFAMM00250262 ZINC20112725 Natural Product
(2R)-2-(2-hydroxyphenyl)-2-[(2R)-2-pyridin-3-ylpiperidin-1-yl]acetonitrile CFAMM00250251 21523441 Patent Compound
AGN-PC-03CCTI CFAMM00250273 54288285 Patent Compound
AGN-PC-0A5BYK CFAMM00250279 3024177 Patent Compound
AC1MIFXJ CFAMM00250247 53713718 Patent Compound
AGN-PC-02XVB4 CFAMM00250246 22254272 Patent Compound
(5-phenylpyridin-3-yl)methanol CFAMM00250283 19418543 Patent Compound
AGN-PC-02D35L
Statistics of CFAM Database
490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
How to cite our database
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering.
Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
Last update by
2014.08.29
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Dr.
Chen Yuzong Deputy
Director of Center for Computational Science and Engineering All rights reserved.
