Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.
Cousin Family Names Seeds Members Histamine H1 receptor Ligand Doxylamine Family 2 91 Aromatic-L-amino-acid decarboxylase Inhibitor Vitamin B6 Family 6 13 cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741 Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265 Citric Acid family 2 58 Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97 5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115 Reverse transcriptase Inhibitor 3'thiacytidine Family 4 29 Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48 Hemoglobin subunit alpha Inhibitor 4-[(5-methoxy-2-methylpheno... 3 12 Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 5 23 Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34 Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3 Adenosine receptor A3 Ligand 4-methoxy-2-phenyl-2h-pyrazolo[4,... 9 49 Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6 Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 2 5 Macrophage migration inhibitory factor Inhibitor 4-((pyridin-4... 1 0 Oestrogen receptor and Estrogen receptor beta Ligand Estrogen ... 7 2 5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35 RAF proto-oncogene serine/threonine-protein kinase Inhibitor 5... 3 7 Cytochrome P450 11B1, mitochondrial Inhibitor 5-(6-methoxynaph... 7 4 Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... 4 5 Estradiol 17-beta-dehydrogenase 1 Inhibitor 3,3'-pyrazine-2,5-... 2 14 Indoleamine 2,3-dioxygenase 1 Inhibitor 5-aminoquinolin-8-ol F... 3 16 Potassium voltage-gated channel subfamily A member 5 Ligand 2-... 5 69 DNA topoisomerase 1 Inhibitor 3-(4-phenyl-2,4'-bipyridin-6-yl)... 4 13 Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapol Family 3 41 Delta-type opioid receptor and Kappa-type opioid receptor Liga... 38 35 Androgen receptor Ligand 11-methyl-6,11-dihydro-5h-benzo[a]car... 7 9 Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20 Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7 Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 8 10 cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 1 Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 3 18 Serine/threonine-protein kinase B-raf inhibitor AGN-PC-00CFYH ... 2 1 Cyclin-dependent kinase 4 and Cyclin-dependent kinase 2 inhibi... 3 1 Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-... 1 0 D(4) dopamine receptor ligand AGN-PC-00SXAZ family 2 4 Serine/threonine-protein kinase Chk1 inhibitor SureCN6786541 f... 3 6 D(1A) dopamine receptor and D(2) dopamine receptor ligand (6aR... 3 6 Estrogen receptor and Estrogen receptor beta ligand SureCN6841... 2 5 Glucocorticoid receptor ligand SureCN3894124 family 3 0 Nociceptin receptor and Potassium voltage-gated channel subfam... 3 9 Beta-3 adrenergic receptor ligand N-[4-[2-[[(2R)-2-hydroxy-2-p... 4 10 D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 2 D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 7 1 Glutamate receptor ionotropic, NMDA 2B ligand SureCN8345160 fa... 1 2 Sodium/hydrogen exchanger 1 inhibitor 2-[(E)-[7-(2-chloropheny... 2 0 Retinoic acid receptor RXR-alpha and Retinoic acid receptor RX... 1 0 cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 2 4 Nuclear receptor ROR-gamma and Induced myeloid leukemia cell d... 1 1 Acetylcholinesterase inhibitor 1,8-dihydroxy-3-(pyridin-1-ium-... 1 0 Cytochrome P450 11B2, mitochondrial and Steroid 17-alpha-hydro... 1 0 Estrogen receptor and Estrogen receptor beta ligand AGN-PC-074... 1 0 Urokinase-type plasminogen activator and Plasminogen inhibitor... 1 0 Aromatase inhibitor AGN-PC-075MRV family 1 3 Arachidonate 15-lipoxygenase and Arachidonate 15-lipoxygenase ... 1 0 Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 1 0 Pyridines and Derivatives Metabolite 4-Hydroxy-4-(3-pyridyl)-b... 1 2 (4-methoxyphenyl)-[(2R)-2-pyridin-3-ylpiperidin-1-yl]phosphina... 1 0 (E)-3-(2-hydroxyphenyl)-1-pyridin-4-ylprop-2-en-1-one NP (e)-3... 1 0
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAMM00250278
CHEMBL338169
Bioactive
(E)-3-(3,4-dihydroxyphenyl)-1-(2-pyridin-3-ylphenyl)prop-2-en-1-one CFAMM00250253
CHEMBL28054
Bioactive
(6aR,12bS)-5,6,6a,7,8,12b-hexahydronaphtho[2,1-c][2,6]naphthyridine-10,11-diol CFAMM00250277
CHEMBL496262
Bioactive
Abiraterone mimetic, 6 CFAMM00250291
CHEMBL404601
Bioactive
4-[1-[2-(4-bromophenyl)prop-2-enyl]pyridin-1-ium-4-yl]phenol;bromide CFAMM00250290
CHEMBL294003
Bioactive
2,6-diethyl-4-[(E)-2-pyridin-3-ylethenyl]phenol CFAMM00250281
CHEMBL414824
Bioactive
1,6-Bpep CFAMM00250280
CHEMBL77680
Bioactive
CHEMBL77680 CFAMM00250287
CHEMBL93828
Bioactive
5-hydroxy-2-(pyridin-4-ylmethyl)-3,4-dihydro-2H-naphthalen-1-one CFAMM00250264
CHEMBL55217
Bioactive
2,6-dimethyl-4-[(E)-2-pyridin-3-ylethenyl]phenol CFAMM00250272
CHEMBL293821
Bioactive
SureCN10385357 CFAMM00250271
CHEMBL2420688
Bioactive
8-chloro-7-isoquinolin-4-ylnaphthalen-2-ol CFAMM00250252
CHEMBL322004
Bioactive
3-[(E)-1,1,1-trifluoro-4-phenyl-2-phenylmethoxybut-3-en-2-yl]-1H-pyridin-2-one CFAMM00250275
CHEMBL2420674
Bioactive
8-chloro-7-pyridin-3-ylnaphthalen-2-ol CFAMM00250268
CHEMBL2420684
Bioactive
5-(1-chloro-7-hydroxynaphthalen-2-yl)pyridin-3-ol CFAMM00250274
CHEMBL2420678
Bioactive
8-chloro-1-fluoro-7-pyridin-3-ylnaphthalen-2-ol CFAMM00250288
CHEMBL2420680
Bioactive
8-chloro-7-(5-fluoropyridin-3-yl)naphthalen-2-ol CFAMM00250270
HMDB33483
Human Metabolite
6,7-Dihydro-4-(hydroxymethyl)-2-(p-hydroxyphenethyl)-7-methyl-5H-2-pyrindinium CFAMM00250249
HMDB30347
Human Metabolite
N-(p-Hydroxyphenethyl)actinidine CFAMM00250262
ZINC20112725
Natural Product
(2R)-2-(2-hydroxyphenyl)-2-[(2R)-2-pyridin-3-ylpiperidin-1-yl]acetonitrile CFAMM00250265
ZINC20112723
Natural Product
(2S)-2-(2-hydroxyphenyl)-2-[(2R)-2-pyridin-3-ylpiperidin-1-yl]acetonitrile CFAMM00250283
19418543
Patent Compound
AGN-PC-02D35L CFAMM00250251
21523441
Patent Compound
AGN-PC-03CCTI CFAMM00250247
53713718
Patent Compound
AGN-PC-02XVB4 CFAMM00250273
54288285
Patent Compound
AGN-PC-0A5BYK CFAMM00250279
3024177
Patent Compound
AC1MIFXJ CFAMM00250246
22254272
Patent Compound
(5-phenylpyridin-3-yl)methanol
Statistics of CFAM Database
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
How to cite our database
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering.
Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
Last update by
2014.08.29
48692 visits since 2014 .........
Dr.
Chen Yuzong
Deputy
Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore
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