CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1773
Family Name Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 11B1, mitochondrial Inhibitor 4-[(3'-hydroxybiphenyl-4-yl)methyl]pyridine Family
No. of Seeds 13 No. of Other Members 26
Family Centroid CFAMM00250286 Functional Category Investigative Drug with Human Metabolite & Natural Product
Superfamily Estradiol 17-beta-dehydrogenase 1 and DNA topoisomerase 1 Binder Superfamily
Class Class 1991

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Doxylamine Family 2 91
Aromatic-L-amino-acid decarboxylase Inhibitor Vitamin B6 Family 6 13
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Citric Acid family 2 58
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
Reverse transcriptase Inhibitor 3'thiacytidine Family 4 29
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Hemoglobin subunit alpha Inhibitor 4-[(5-methoxy-2-methylpheno... 3 12
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 5 23
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Adenosine receptor A3 Ligand 4-methoxy-2-phenyl-2h-pyrazolo[4,... 9 49
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 2 5
Macrophage migration inhibitory factor Inhibitor 4-((pyridin-4... 1 0
Oestrogen receptor and Estrogen receptor beta Ligand Estrogen ... 7 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
RAF proto-oncogene serine/threonine-protein kinase Inhibitor 5... 3 7
Cytochrome P450 11B1, mitochondrial Inhibitor 5-(6-methoxynaph... 7 4
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... 4 5
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3,3'-pyrazine-2,5-... 2 14
Indoleamine 2,3-dioxygenase 1 Inhibitor 5-aminoquinolin-8-ol F... 3 16
Potassium voltage-gated channel subfamily A member 5 Ligand 2-... 5 69
DNA topoisomerase 1 Inhibitor 3-(4-phenyl-2,4'-bipyridin-6-yl)... 4 13
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapol Family 3 41
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 38 35
Androgen receptor Ligand 11-methyl-6,11-dihydro-5h-benzo[a]car... 7 9
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 8 10
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 1
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 3 18
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-00CFYH ... 2 1
Cyclin-dependent kinase 4 and Cyclin-dependent kinase 2 inhibi... 3 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-... 1 0
D(4) dopamine receptor ligand AGN-PC-00SXAZ family 2 4
Serine/threonine-protein kinase Chk1 inhibitor SureCN6786541 f... 3 6
D(1A) dopamine receptor and D(2) dopamine receptor ligand (6aR... 3 6
Estrogen receptor and Estrogen receptor beta ligand SureCN6841... 2 5
Glucocorticoid receptor ligand SureCN3894124 family 3 0
Nociceptin receptor and Potassium voltage-gated channel subfam... 3 9
Beta-3 adrenergic receptor ligand N-[4-[2-[[(2R)-2-hydroxy-2-p... 4 10
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 2
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 7 1
Glutamate receptor ionotropic, NMDA 2B ligand SureCN8345160 fa... 1 2
Sodium/hydrogen exchanger 1 inhibitor 2-[(E)-[7-(2-chloropheny... 2 0
Retinoic acid receptor RXR-alpha and Retinoic acid receptor RX... 1 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 2 4
Nuclear receptor ROR-gamma and Induced myeloid leukemia cell d... 1 1
Acetylcholinesterase inhibitor 1,8-dihydroxy-3-(pyridin-1-ium-... 1 0
Cytochrome P450 11B2, mitochondrial and Steroid 17-alpha-hydro... 1 0
Estrogen receptor and Estrogen receptor beta ligand AGN-PC-074... 1 0
Urokinase-type plasminogen activator and Plasminogen inhibitor... 1 0
Aromatase inhibitor AGN-PC-075MRV family 1 3
Arachidonate 15-lipoxygenase and Arachidonate 15-lipoxygenase ... 1 0
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 1 0
Pyridines and Derivatives Metabolite 4-Hydroxy-4-(3-pyridyl)-b... 1 2
(4-methoxyphenyl)-[(2R)-2-pyridin-3-ylpiperidin-1-yl]phosphina... 1 0
(E)-3-(2-hydroxyphenyl)-1-pyridin-4-ylprop-2-en-1-one NP (e)-3... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00250256 DNC011032 Investigative Drug 3-Fluoro-4'-(pyridin-4-ylmethyl)biphenyl-4-ol
CFAMM00250286 DNC011029 Investigative Drug 4-[(3'-Hydroxybiphenyl-4-yl)methyl]pyridine
CFAMM00250255 DNC011033 Investigative Drug 3-fluoro-4'-(1-(pyridin-4-yl)propyl)biphenyl-4-ol
CFAMM00250284 DNC005716 Investigative Drug 6-Pyridin-3-yl-naphthalen-2-ol
CFAMM00250259 DNC011034 Investigative Drug 4'-(Pyridin-4-ylmethyl)biphenyl-3,4-diol
CFAMM00250254 DNC007757 Investigative Drug 5-(1,1-dimethyl-heptyl)-2-pyridin-3-yl-phenol
CFAMM00250258 DNC011030 Investigative Drug 4'-(1-(pyridin-4-yl)propyl)biphenyl-3-ol
CFAMM00250276 DNC011113 Investigative Drug 6-[4-(Pyridin-4-ylmethyl)phenyl]naphthalen-2-ol
CFAMM00250269 DNC011103 Investigative Drug 4-[(4'-Hydroxybiphenyl-4-yl)methyl]pyridine
CFAMM00250282 DNC008114 Investigative Drug 6-(3-(pyridin-4-yl)phenyl)naphthalen-2-ol
CFAMM00250257 DNC011031 Investigative Drug 4'-(2-methyl-1-(pyridin-4-yl)propyl)biphenyl-3-ol
CFAMM00250289 DNC011102 Investigative Drug 3-[(4'-Hydroxybiphenyl-4-yl)methyl]pyridine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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