CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1778
Family Name Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-aminobenzyl)-1h-imidazole Family
No. of Seeds 3 No. of Other Members 6
Family Centroid CFAMM00250351 Functional Category Investigative Drug
Superfamily Cytochrome P450 11B1, mitochondrial and Steroid 17-alpha-hydroxylase/17,20 lyase Binder Superfamily
Class Class 1989

Cousin Family NamesSeedsMembers
Cytochrome P450 3A4 Inhibitor Clotrimazole Family 16 145
5-hydroxytryptamine receptor 1D Ligand Rizatriptan Family 7 460
Alpha-2 adrenergic receptor Ligand Dexmedetomidine Family 32 639
Benzodiazepine receptor Ligand Midazolam Family 5 160
Toll-like receptor 7 Ligand Imiquimod Family 3 237
14-alpha sterol demethylase Inhibitor Butoconazole Family 2 53
Histamine H1 receptor Ligand Mizolastine Family 14 603
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Farnesyltransferase beta subunit, putative Inhibitor BMS214662... 11 65
Telomerase protein component 1 Inhibitor GRN163L Family 5 29
Vascular endothelial growth factor Inhibitor PTC299 Family 6 145
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
HCV NS4B protein Inhibitor Clemizole Family 2 43
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
Histamine H3 receptor and Histamine H4 receptor Ligand Clobenp... 31 38
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Prostaglandin G/H synthase 2 Inhibitor RWJ-67657 Family 3 33
Histamine H3 receptor Ligand SCH79687 Family 11 29
Farnesyltransferase beta subunit, putative and Protein farnesy... 20 81
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-cyanobenzyl... 14 13
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 5 7
Aromatase and Thromboxane-A synthase Inhibitor 6-(1h-imidazol-... 3 8
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 6-im... 2 30
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 3 2
Alpha-1A adrenergic receptor Ligand A-315456 Family 7 17
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 45
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
Indoleamine 2,3-dioxygenase 1 Inhibitor 3-(4h-imidazol-4-yl)be... 6 3
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 6 6
Cytochrome P450 11B1, mitochondrial Inhibitor 3-(1-benzyl-1h-i... 3 5
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-bromobenzyl... 3 0
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-cyanobenzyl... 2 1
Steroid 17-alpha-hydroxylase/17,20 lyase Inhibitor 1-(4-nitrob... 3 5
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 2 8
Histamine H3 receptor Ligand 4-(2-(phenylamino)ethyl)-1h-imida... 5 16
Aromatase Inhibitor 2-(1h-imidazol-1-yl)-1-(4-nitrophenyl)etha... 2 29
Type-2 angiotensin II receptor Ligand L-158809 Family 22 136
Steroid 17-alpha-hydroxylase/17,20 lyase Inhibitor 1-(3,4-dich... 1 0
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 4
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-(2-(4-... 25 10
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 7 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 3 12
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 7
Platelet-activating factor receptor ligand AGN-PC-0750SP family 4 0
Histamine H1 receptor and Alpha-1B adrenergic receptor ligand ... 1 6
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
D(4) dopamine receptor and D(2) dopamine receptor ligand 4-met... 13 8
Histamine H3 receptor and Histamine H2 receptor ligand SureCN7... 2 2
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 10 6
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 1
Protein farnesyltransferase alpha subunit and Protein farnesyl... 5 0
Dipeptidyl peptidase 4 inhibitor 7-(aminomethyl)-6-(2-chloroph... 2 5
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 1
Gamma-aminobutyric acid receptor subunit pi and Gamma-aminobut... 4 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 5
Glutaminyl-peptide cyclotransferase inhibitor SureCN10144417 f... 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00250346 DNC005726 Investigative Drug 1-Naphthalen-2-yl-1H-imidazole
CFAMM00250351 DNC010494 Investigative Drug 1-(4-Aminobenzyl)-1H-imidazole
CFAMM00250350 DNC010499 Investigative Drug 3-((1H-imidazol-1-yl)methyl)aniline

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27163 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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