CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1786
Family Name Metabotropic glutamate receptor 5 Ligand 2-m-tolyl-1,8-naphthyridine Family
No. of Seeds 7 No. of Other Members 11
Family Centroid CFAMM00250505 Functional Category Investigative Drug
Superfamily Transient receptor potential cation channel subfamily V member 1 Ligand NGD-8243 Superfamily
Class Class 903

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
5-hydroxytryptamine receptor 1D Ligand Rizatriptan Family 7 460
Alpha-2 adrenergic receptor Ligand Dexmedetomidine Family 32 639
Benzodiazepine receptor Ligand Midazolam Family 5 160
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
Toll-like receptor 7 Ligand Imiquimod Family 3 237
Amiloride-sensitive sodium channel subunit alpha Ligand Triamt... 8 98
Peptide deformylase, mitochondrial Inhibitor Pyrimethamine Family 10 145
Type-1 angiotensin II receptor Ligand Forasartan Family 3 253
Histamine H1 receptor Ligand Mizolastine Family 14 603
Sarcoplasmic/endoplasmic reticulum calcium ATPase inhibitor qu... 2 60
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Transient receptor potential cation channel subfamily V member... 16 295
Transient receptor potential cation channel subfamily V member... 15 457
Vascular endothelial growth factor Inhibitor PTC299 Family 6 145
Cyclin-dependent kinase 2 Inhibitor Seliciclib Family 29 292
Hepatocyte growth factor receptor Ligand SGX523 Family 1 15
HER Inhibitor AC480 Family 4 67
Vascular endothelial growth factor receptor 2 Ligand Ptk787/zk... 5 38
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Tyrosine-protein kinase JAK2 Inhibitor INCB18424 Family 3 130
C-reactive protein Inhibitor ISIS-CRP Family 4 105
Reverse transcriptase Inhibitor Dapivirine Family 5 72
Translocator protein Inhibitor Emapunil Family 7 89
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Adenosine receptor A1 Ligand SLV320 Family 6 79
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 9
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
Gamma-aminobutyric acid A receptor Ligand Ocinaplon Family 1 10
HCV NS4B protein Inhibitor Clemizole Family 2 43
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
GDC-0349 family 44 77
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
PF-4217903 family 14 65
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
Corticotropin-releasing factor receptor 1 Ligand CP-154526 Family 9 29
Class II cytokine receptor Ligand IL-10 Family 7 45
D(4) dopamine receptor Ligand L-745,870 Family 30 205
5-hydroxytryptamine receptor 2B Ligand MT-500 Family 8 39
Glucan synthesis regulatory protein Inhibitor Pyridobenzimidaz... 2 12
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Prostaglandin G/H synthase 2 Inhibitor RWJ-67657 Family 3 33
Interleukin-1 receptor type 1 and Mitogen-activated protein ki... 7 151
Epidermal growth factor receptor and Receptor tyrosine-protein... 11 138
Carbonic anhydrase 2 Inhibitor Cyanamide Family 2 32
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
TGF-beta receptor type-1 Ligand 4-(3-pyridin-2-yl-1h-pyrazol-4... 3 63
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... 13 14
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 32
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Peptide deformylase, mitochondrial Inhibitor 5-phenethyl-quina... 5 14
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-cyanobenzyl... 14 13
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Adenosine receptor A2a and Adenosine receptor A3 Ligand 5-buty... 3 18
Epidermal growth factor receptor Ligand N*4*-(3-bromo-phenyl)-... 7 11
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Glycogen synthase kinase-3 beta Inhibitor N-(6-(pyridin-4-yl)-... 4 23
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
Epidermal growth factor receptor Ligand Benzo[g]quinazolin-4-y... 5 3
Epidermal growth factor receptor Ligand (3-bromo-phenyl)-quina... 7 5
Aromatase and Thromboxane-A synthase Inhibitor 6-(1h-imidazol-... 3 8
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Plasminogen and Tissue-type plasminogen activator Inhibitor N-... 1 5
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Adenosine receptor A1 Ligand Phenyl-(9-phenyl-9h-purin-6-yl)-a... 7 12
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
Epidermal growth factor receptor Ligand N4-(3-chlorophenyl)qui... 7 39
Alpha-1A adrenergic receptor Ligand A-315456 Family 7 17
Metabotropic glutamate receptor 5 Ligand 3-(1-pyridin-2-yl-1h-... 3 6
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 4 30
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 14 22
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
DNA-dependent protein kinase catalytic subunit Inhibitor 2-mor... 2 6
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... 2 9
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2,6... 22 18
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
Cathepsin K Inhibitor 4-phenyl-6-propylpyrimidine-2-carbonitri... 6 10
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-amin... 4 11
Fatty-acid amide hydrolase 1 Inhibitor JNJ-1661010 Family 3 14
Aromatase Inhibitor NSC-356781 Family 3 10
Macrophage migration inhibitory factor Inhibitor 4-iodo-6-phen... 5 4
Oestrogen receptor Ligand 4-benzyl-2,6-diisobutylamino-pyrimid... 5 37
Histamine H4 receptor Ligand A-943931 Family 14 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Glycogen synthase kinase-3 beta Inhibitor 4-(5-bromo-1h-indol-... 7 18
Aurora kinase B and Tyrosine-protein kinase Lck Inhibitor CGP-... 2 29
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-bromobenzyl... 3 0
Histamine H3 receptor Ligand 4-(2-(phenylamino)ethyl)-1h-imida... 5 16
Type-2 angiotensin II receptor Ligand L-158809 Family 22 136
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
Peptide deformylase, mitochondrial Inhibitor 7h-pyrrolo[3,2-f]... 2 10
Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... 5 35
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Reverse transcriptase Inhibitor PT-109 Family 6 7
Metabotropic glutamate receptor 5 Ligand 2-methyl-7-m-tolyl-1,... 5 2
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 63
Metabotropic glutamate receptor 5 Ligand 2-(3,5-dichlorophenyl... 2 3
Metabotropic glutamate receptor 5 Ligand 2-(3-bromophenyl)-7-m... 3 1
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 2 2
Metabotropic glutamate receptor 5 Ligand 7-m-tolyl-1,6-naphthy... 4 2
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Metabotropic glutamate receptor 5 Ligand 5-(2-m-tolylethynyl)p... 7 49
Xanthine dehydrogenase/oxidase Inhibitor 3,5-di(pyridin-4-yl)-... 6 3
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... 6 16
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 4
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... 3 13
Adenosine kinase inhibitor abt-702 family 14 1
Prothrombin inhibitor SureCN5856722 family 3 16
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 14 4
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07ZB89 family 6 13
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 7 3
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 4 7
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 9
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 3 12
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 1
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 2 5
Ephrin type-B receptor 4 ligand SureCN3289519 family 4 2
Platelet-activating factor receptor ligand AGN-PC-0750SP family 4 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 7 4
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 6 1
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Adenosine kinase inhibitor 5-[3-(3-bromophenyl)propyl]-6-[2-(6... 3 0
Transient receptor potential cation channel subfamily V member... 1 0
Serine/threonine-protein kinase D1 inhibitor SureCN1424142 family 13 8
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
Adenosine receptor A3 and Adenosine receptor A2a ligand SureCN... 8 7
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 27
DNA-dependent protein kinase catalytic subunit and Tyrosine-pr... 2 10
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 1 0
Epidermal growth factor receptor ligand pyrido[4,3-d]pyrimidin... 11 0
Epidermal growth factor receptor ligand AGN-PC-076GXM family 6 0
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 3 11
Serine/threonine-protein kinase B-raf inhibitor SureCN3495829 ... 24 0
Serine/threonine-protein kinase B-raf inhibitor SureCN3495787 ... 8 1
Survival motor neuron protein and Menin inhibitor CHEMBL132797... 1 1
Adenosine receptor A2a ligand AGN-PC-077RWY family 4 5
Type-1B angiotensin II receptor ligand SureCN683399 family 3 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 7 9
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 8
Mitogen-activated protein kinase 14 inhibitor AGN-PC-03XQYG fa... 7 1
Prothrombin and Survival motor neuron protein inhibitor CHEMBL... 2 14
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 5 0
Dihydrofolate reductase inhibitor AC1LAKQL family 3 1
Prelamin-A/C inhibitor CHEMBL1472945 family 1 32
Dihydrofolate reductase inhibitor AC1LAKWV family 2 0
Dihydrofolate reductase inhibitor 6-[[(4-chloronaphthalen-1-yl... 2 1
Nuclear receptor ROR-gamma and 15-hydroxyprostaglandin dehydro... 1 1
Nuclear receptor ROR-gamma and Mitogen-activated protein kinas... 1 10
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 5 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 7
Insulin-like growth factor 1 receptor ligand AGN-PC-09QIDN family 1 3
Glycogen synthase kinase-3 beta and Dual specificity protein k... 4 5
Signal transducer and activator of transcription 6 inhibitor A... 3 0
Mitogen-activated protein kinase 10 and Transcription factor A... 4 4
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 5
Nociceptin receptor and Potassium voltage-gated channel subfam... 10 1
Fatty-acid amide hydrolase 1 inhibitor [5-(4-chlorophenyl)tria... 2 2
Histone deacetylase 1 inhibitor (E)-N-hydroxy-3-[4-[[2-(1H-pyr... 2 8
Tyrosine-protein kinase JAK2 inhibitor N-tert-butyl-3-[2-[3-fl... 4 14
Aurora kinase A and Cyclin-dependent kinase 1 inhibitor N-[4-[... 12 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 11
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 3 0
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL1... 7 4
TGF-beta receptor type-1 ligand 3-(6-methylpyridin-2-yl)-N-phe... 21 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 1
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 3
Metabotropic glutamate receptor 5 ligand AGN-PC-075GBZ family 2 5
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 3 3
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 4 ... 2 1
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 3 0
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Mitogen-activated protein kinase 14 inhibitor 4-(2-chloropheny... 4 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Cell division cycle 7-related protein kinase and Protein DBF4 ... 15 7
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 1 0
Vascular endothelial growth factor receptor 1 and Vascular end... 4 0
Aurora kinase B and Vascular endothelial growth factor recepto... 1 2
Protein kinase C theta type and Leucine-rich repeat serine/thr... 1 1
Transient receptor potential cation channel subfamily V member... 4 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 11 0
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 8 5
Epidermal growth factor receptor ligand N-[3-[3-methyl-7-[4-(4... 2 1
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 0
TGF-beta receptor type-1 and TGF-beta receptor type-2 ligand S... 2 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 1
Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... 4 5
Casein kinase II subunit alpha and Homeodomain-interacting pro... 5 0
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-(cyc... 3 0
Lysine--tRNA ligase inhibitor N-[2-(2-piperazin-1-ylpyridin-4-... 5 0
Nociceptin receptor and Mu-type opioid receptor ligand 1-(1,2-... 1 1
Mitogen-activated protein kinase 14 inhibitor imidazole 81 family 2 1
Aurora kinase A and Cyclin-dependent kinase 4 inhibitor 7-cycl... 1 0
High affinity nerve growth factor receptor ligand N-[3-amino-5... 4 10
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152398 family 16 1
Succinate receptor 1 ligand N-[[4-(3-methylphenyl)phenyl]methy... 2 14
Serine/threonine-protein kinase SMG1 and Cyclin-dependent kina... 3 1
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 3 4
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 1
Beta-secretase 1 and Potassium voltage-gated channel subfamily... 3 4
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 17 0
Metabotropic glutamate receptor 2 ligand 3-(cyclopropylmethyl)... 1 1
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17d ... 5 9
Somatostatin receptor type 3 and Potassium voltage-gated chann... 3 3
Serine/threonine-protein kinase PLK2 and Serine/threonine-prot... 4 8
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206614 family 2 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 4
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 5
Adenosine receptor A1 ligand N-butyl-5-phenyl-3-[[2-(trifluoro... 7 2
Casein kinase II subunit alpha inhibitor 2pvj family 3 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 6 3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 5
Alpha-1A adrenergic receptor and D(2) dopamine receptor ligand... 1 0
Protein kinase C theta type and Protein kinase C delta type in... 9 0
Fatty-acid amide hydrolase 1 inhibitor 4-(3-phenyl-1,2,4-thiad... 2 1
Serine/threonine-protein kinase mTOR inhibitor 2-[4-[4-[(3S)-3... 3 0
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Cholinesterase inhibitor 4-[4,5-diphenyl-1-[7-(1,2,3,4-tetrahy... 2 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 5 2
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 0
Motilin receptor ligand SureCN2004322 family 2 1
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 2 0
TGF-beta receptor type-2 and Vascular endothelial growth facto... 2 1
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
ALK tyrosine kinase receptor ligand 3-[1-[(3-fluorophenyl)meth... 2 0
D(3) dopamine receptor and Muscarinic acetylcholine receptor M... 8 2
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
Cathepsin K inhibitor SureCN4141224 family 3 0
Cyclin-dependent kinase 1 and Proto-oncogene tyrosine-protein ... 5 13
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 1 5
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 16 7
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 3 0
Cathepsin K inhibitor 4-[2,2-dimethylpropyl-[[4-(1,2,4-triazol... 2 1
LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-(3-cyanophenyl)-... 4 0
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 10 0
Cathepsin K and Cathepsin L1 inhibitor 5-[3-(3,4-dihydro-1H-is... 2 0
Cathepsin K inhibitor 4-[2,2-dimethylpropyl-[[4-[3-(4-piperidi... 2 0
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 1 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 14 14
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 5 4
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 3
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 5 1
Corticotropin-releasing factor receptor 1 ligand 4-[7-(dipropy... 1 1
Adenosine kinase inhibitor SureCN8248615 family 2 3
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 4-[6-... 3 3
Corticotropin-releasing factor receptor 1 ligand AGN-PC-00FF1P... 1 3
Nociceptin receptor and Mu-type opioid receptor ligand SureCN5... 1 0
G2/mitotic-specific cyclin-B2 and Cyclin-dependent kinase 1 in... 2 1
Proto-oncogene tyrosine-protein kinase Src and Fibroblast grow... 3 4
High affinity nerve growth factor receptor ligand SureCN490352... 3 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 7 0
Metabotropic glutamate receptor 1 ligand AGN-PC-00FV3S family 2 0
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 1 0
Ribosomal protein S6 kinase beta-1 and Aurora kinase B inhibit... 1 5
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(2-ph... 4 0
Serine/threonine-protein kinase B-raf and Mitogen-activated pr... 16 5
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
LIM domain kinase 1 and LIM domain kinase 2 inhibitor (2S)-N'-... 9 0
C-C chemokine receptor type 5 ligand AC1MHPAK family 5 1
Dihydrofolate reductase type 1 and Dihydrofolate reductase inh... 1 0
Adenosine kinase inhibitor AGN-PC-074DKZ family 1 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 5
Reverse transcriptase/RNaseH inhibitor 181305-52-2 family 1 0
P2Y purinoceptor 14 inhibitor AGN-PC-0A9S8H family 3 2
Corticotropin-releasing factor receptor 1 ligand 5-N,5-N-bis(c... 2 0
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 1 0
Nuclear receptor ROR-gamma and Lysine-specific demethylase 4E ... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00250496 DNC013375 Investigative Drug 7-methyl-2-phenylpyrido[2,3-d]pyrimidine
CFAMM00250509 DNC013379 Investigative Drug 7-methyl-2-m-tolylpyrido[2,3-d]pyrimidine
CFAMM00250500 DNC005779 Investigative Drug 5-Azido-6-benzyl-2-methyl-[1,8]naphthyridine
CFAMM00250499 DNC013410 Investigative Drug 3-(1,8-naphthyridin-2-yl)benzonitrile
CFAMM00250505 DNC013409 Investigative Drug 2-m-tolyl-1,8-naphthyridine
CFAMM00250498 DNC013389 Investigative Drug 2-phenyl-1,8-naphthyridine
CFAMM00250504 DNC013407 Investigative Drug 2-(3,4-dimethylphenyl)-1,8-naphthyridine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27701 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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