CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1794
Family Name Mitogen-activated protein kinase 14 Inhibitor 4-(2-ethyl-4-m-tolyl-thiazol-5-yl)-pyridine Family
No. of Seeds 14 No. of Other Members 41
Family Centroid CFAMM00250850 Functional Category Investigative Drug with Human Metabolite
Superfamily Metabotropic glutamate receptor 5 and Mitogen-activated protein kinase 14 Binder Superfamily
Class Class 1981

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B ligand triptan Almotriptan Family 8 438
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
Prostaglandin G/H synthase 2 Inhibitor Etoricoxib Family 2 99
Histamine H1 receptor Ligand Pheniramine Family 10 380
D(1B) dopamine receptor Ligand LE-300 Family 65 452
5-hydroxytryptamine receptor Ligand Sl65.0472 Family 2 16
Urokinase-type plasminogen activator Inhibitor Thieno[2,3-b]py... 1 12
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Platelet-derived growth factor receptor alpha and Platelet-der... 5 48
Cytochrome P450 3A4 Inhibitor 3-(3-methylthiophen-2-yl)pyridin... 5 27
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 16
Metabotropic glutamate receptor 5 Ligand 2-methyl-4-(pyridin-3... 10 35
TGF-beta receptor type-1 Ligand 4-pyridin-2-yl-5-quinolin-4-yl... 4 23
Metabotropic glutamate receptor 5 Ligand N-[4-(3-pyridylethyny... 2 10
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(thiophen... 9 66
Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibi... 6 64
C-C chemokine receptor type 4 Ligand N-(4-tert-butylthiazol-2-... 3 9
Vascular endothelial growth factor receptor 2 Ligand 3-(4-amin... 2 5
Sodium-dependent dopamine transporter and Sodium-dependent nor... 3 12
Cyclin-dependent kinase 5 Inhibitor 1-phenyl-3-(2-(pyridin-4-y... 3 53
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 14 19
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 4 23
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-264... 6 32
Acetylcholinesterase and Cholinesterase Inhibitor 1,9-bis(pyri... 8 38
Amine oxidase [flavin-containing] B Inhibitor 2-(2-cyclohexyli... 6 44
Histamine H3 receptor Ligand ST-1025 Family 2 22
Translocator protein Inhibitor 5-phenyl-6-thia-10b-aza-benzo[e... 1 2
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
C-C chemokine receptor type 5 ligand AC1LAJBP family 2 6
RAC-alpha serine/threonine-protein kinase and Cyclin-dependent... 2 7
Histamine H3 receptor and Potassium voltage-gated channel subf... 6 20
Potassium voltage-gated channel subfamily H member 2 and Neuro... 2 3
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(4-acet... 4 12
Histamine H3 receptor and Potassium voltage-gated channel subf... 6 14
Histamine H1 receptor and Cytochrome P450 2D6 ligand 2-[3-[(1R... 1 10
Mitogen-activated protein kinase 14 inhibitor 4-[4-(4-fluoroph... 2 0
Neuropeptide Y receptor type 5 ligand N-[[(1S,5R)-3-(1-phenyle... 5 1
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 1
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 2 4
Amine oxidase [flavin-containing] B inhibitor 4-(4-fluoropheny... 3 4
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 3 7
Platelet-activating factor receptor ligand Foropafant family 2 0
Substance-K receptor and Cytochrome P450 2D6 ligand 158848-32-... 4 4
Histamine H1 receptor and Cytochrome P450 2D6 ligand N-methyl-... 1 0
Sodium-dependent serotonin transporter inhibitor SureCN9171444... 2 0
5-hydroxytryptamine receptor 2A and Alpha-1B adrenergic recept... 8 6
Sigma non-opioid intracellular receptor 1 ligand SureCN7434677... 1 0
Sodium-dependent serotonin transporter inhibitor 3-[[(3S)-1-az... 1 1
Metabotropic glutamate receptor 4 and Potassium voltage-gated ... 2 15
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 7 21
Mitogen-activated protein kinase 14 inhibitor N-[4-[2-ETHYL-4-... 4 5
Amyloid beta A4 protein and Luciferin 4-monooxygenase inhibito... 11 46
D(4) dopamine receptor ligand SureCN8706945 family 4 10
Aromatase inhibitor 2-(2-chloropyridin-4-yl)-4-pyridin-3-yl-1,... 1 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 0
Adenosine receptor A2b and Adenosine receptor A3 ligand 3-[5-(... 4 2
Serine/threonine-protein kinase Chk1 inhibitor 5-[5-(1-methylp... 3 2
Vascular endothelial growth factor receptor 2 ligand N-(1,3-Th... 4 4
Sodium-dependent dopamine transporter and Sodium-dependent ser... 3 2
Metabotropic glutamate receptor 5 ligand 3-methyl-1-(2-thiophe... 2 1
Prostaglandin G/H synthase 2 inhibitor AGN-PC-03VWQ9 family 3 5
5-hydroxytryptamine receptor 1A and Alpha-2C adrenergic recept... 2 2
Epidermal growth factor receptor and Vascular endothelial grow... 14 19
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 3 4
Amyloid beta A4 protein inhibitor SureCN2465837 family 4 2
Mitogen-activated protein kinase 14 inhibitor 303163-37-3 family 1 2
Protein kinase C theta type and Protein kinase C delta type in... 4 5
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 1 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 1 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 4 1
5-hydroxytryptamine receptor 6 and Cytochrome P450 3A4 ligand ... 1 0
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 2 4
Sodium/hydrogen exchanger 1 inhibitor 2-[(E)-[2-(1,3-benzothia... 1 3
Vascular endothelial growth factor receptor 2 and Vascular end... 1 1
Metabotropic glutamate receptor 5 and Cytochrome P450 1A2 liga... 2 1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 5 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 1 0
5-phenyl-1,3-thiazole NP 5-phenylthiazole Family 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00250839 CHEMBL564144 Bioactive 873693-47-1
CFAMM00250812 CHEMBL190180 Bioactive AGN-PC-075INF
CFAMM00250857 CHEMBL1957214 Bioactive 4-pyridin-3-yl-2-pyridin-4-yl-1,3-thiazole
CFAMM00250834 CHEMBL369310 Bioactive SureCN3458329
CFAMM00250855 CHEMBL1957218 Bioactive 2-(3-methylpyridin-4-yl)-4-pyridin-3-yl-1,3-thiazole
CFAMM00250847 CHEMBL183864 Bioactive SureCN7425347
CFAMM00250829 CHEMBL511603 Bioactive 4-[2-(3-fluoro-5-pyridin-3-ylphenyl)ethynyl]-2-methyl-1,3-thiazole
CFAMM00250861 CHEMBL1091774 Bioactive SureCN4847863
CFAMM00250820 DNC014066 Investigative Drug 2-Phenyl-5-(2-methylthiazol-4ylethynyl)pyridine
CFAMM00250850 DNC005794 Investigative Drug 4-(2-Ethyl-4-m-tolyl-thiazol-5-yl)-pyridine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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