CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1803
Family Name Metabotropic glutamate receptor 5 Ligand (3-ethoxy-pyridin-2-yl)-pyridin-2-yl-amine Family
No. of Seeds 3 No. of Other Members 12
Family Centroid CFAMM00251092 Functional Category Investigative Drug
Superfamily Metabotropic glutamate receptor 5 Ligand (3-ethoxy-pyridin-2-yl)-pyridin-2-yl-amine Superfamily
Class Class 1037

Cousin Family NamesSeedsMembers
Acetylcholinesterase Inhibitor Pyridostigmine Family 5 197
Histamine H1 receptor Ligand Mepyramine Family 5 65
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Serine/threonine-protein kinase Chk1 and Serine/threonine-prot... 23 121
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
Neuronal acetylcholine receptor subunit alpha-4 Ligand Isproni... 49 172
Epidermal growth factor receptor and Receptor tyrosine-protein... 8 31
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
SB1518 family 7 103
Nicotinic acetylcholine receptor Ligand Dianicline Family 6 13
Tissue-type plasminogen activator Inhibitor N-(7-benzyloxy-iso... 4 37
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Fatty-acid amide hydrolase 1 Inhibitor Pyridin-3-yl 4-butoxybe... 10 5
Reverse transcriptase Inhibitor UK-129485 Family 23 221
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
5-hydroxytryptamine receptor 1A Ligand CP-293019 Family 9 24
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Neuronal acetylcholine receptor subunit beta-2 Ligand ABT-594 ... 4 5
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 3
Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... 2 11
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 4
Neuropeptide Y receptor type 5 ligand 8-[[(5-cyclobutyloxypyri... 1 0
D(2) dopamine receptor and Alpha-1B adrenergic receptor ligand... 2 8
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Dihydrofolate reductase inhibitor AC1L9XPA family 6 5
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 8 8
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 11 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor Sure... 14 8
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 6 12
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Ephrin type-B receptor 4 ligand SureCN5131922 family 4 0
Ephrin type-B receptor 4 and Vascular endothelial growth facto... 2 0
Glucose-dependent insulinotropic receptor ligand propan-2-yl 4... 2 54
cGMP-specific 3',5'-cyclic phosphodiesterase and Rod cGMP-spec... 42 3
cGMP-specific 3',5'-cyclic phosphodiesterase and Rod cGMP-spec... 24 5
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 3 0
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Neuronal acetylcholine receptor subunit alpha-2 and Neuronal a... 6 1
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-07... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 5 0
Beta-secretase 1 and Beta-secretase 2 inhibitor 7-fluoro-3-(5-... 2 7
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 0
TRAF2 and NCK-interacting protein kinase inhibitor 4-methoxy-3... 4 1
Orexin receptor type 1 and Orexin receptor type 2 ligand (1R,2... 6 1
Potassium voltage-gated channel subfamily KQT member 2 ligand ... 3 4
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
Beta-3 adrenergic receptor and Beta-2 adrenergic receptor liga... 5 13
Dihydrofolate reductase inhibitor AGN-PC-001U7R family 3 0
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase inhibitor 1-... 1 3
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 7 5
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 2
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Bifunctional epoxide hydrolase 2 and Voltage-dependent L-type ... 2 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 1
TGF-beta receptor type-1 ligand SureCN373216 family 3 14
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 4 3
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 6 0
Metabotropic glutamate receptor 5 ligand AGN-PC-09QJ1Q family 1 0
Glucokinase inhibitor 4-methyl-N-[3-phenylmethoxy-5-(pyridin-2... 1 8
Corticotropin-releasing factor receptor 1 ligand N-[(1R,2S)-2-... 3 0
Coagulation factor X and Cationic trypsin inhibitor AGN-PC-073... 1 1
TGF-beta receptor type-1 ligand 2wou family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00251084 CHEMBL261673 Bioactive 4-(2,2-dimethylpropylamino)-5-(3-pyridin-3-yloxyprop-1-ynyl)pyrimidine-2-carbonitrile
CFAMM00251092 DNC005825 Investigative Drug (3-Ethoxy-pyridin-2-yl)-pyridin-2-yl-amine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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