CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1804
Family Name Caspase-3 and Caspase-1 Inhibitor Pralnacasan Family
No. of Seeds 6 No. of Other Members 8
Family Centroid CFAMM00251104 Functional Category Investigative Drug
Superfamily Caspase-3 and Caspase-1 Inhibitor Pralnacasan Superfamily
Class Class 137

Cousin Family NamesSeedsMembers
Caspase-1 and Caspase-8 inhibitor (4S,7S,11aS)-2-(benzenesulfo... 3 0
Caspase-1 inhibitor (3S)-3-[[(4S,7S,9Z,11aS)-7-(isoquinoline-1... 2 0


External ID

Functional Category

Molecule Name

CFAMM00251106 CHEMBL196753 Bioactive (4S,7S,11aS)-N-[(3S)-2-hydroxy-5-oxooxolan-3-yl]-7-(isoquinoline-1-carbonylamino)-6-oxo-3,4,7,8,9,10,11,11a-octahydro-1H-[1,4]oxazino[4,3-a]azocine-4-carboxamide
CFAMM00251100 CHEMBL199445 Bioactive (4S,7S,9Z,11aS)-N-[(3S)-2-hydroxy-5-oxooxolan-3-yl]-7-(isoquinoline-1-carbonylamino)-6-oxo-3,4,7,8,11,11a-hexahydro-1H-[1,4]oxazino[4,3-a]azocine-4-carboxamide
CFAMM00251098 CHEMBL437105 Bioactive (3S)-3-[[(4S,7S)-7-(isoquinoline-1-carbonylamino)-6,10-dioxo-2,3,4,7,8,9-hexahydro-1H-pyridazino[1,2-a]diazepine-4-carbonyl]amino]-4-oxobutanoic acid
CFAMM00251103 CHEMBL382090 Bioactive (4S,7S,11aS)-N-[(3S)-2-hydroxy-5-oxooxolan-3-yl]-7-(isoquinoline-1-carbonylamino)-6-oxo-1,2,3,4,7,8,9,10,11,11a-decahydropyrazino[1,2-a]azocine-4-carboxamide
CFAMM00251101 CHEMBL437526 Bioactive Pralnacasan
CFAMM00251104 DNC005826 Investigative Drug PRALNACASAN

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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