CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1808
Family Name Interstitial collagenase Inhibitor N-hydroxycarbamoylmethyl-4-methoxy-benzamide Family
No. of Seeds 5 No. of Other Members 24
Family Centroid CFAMM00251137 Functional Category Investigative Drug with Natural Product
Superfamily Histone deacetylase 2 and Histone deacetylase 1 Binder Superfamily 4
Class Class 36

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Dyclonine F... 6 174
Sodium channel protein type 5 subunit alpha Ligand Flecainide ... 2 162
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Glycoprotein IIb/IIIa receptor Ligand Tirofiban Family 4 173
Zucapsacin family 7 177
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
C-C chemokine receptor type 5 Ligand GW873140 Family 6 78
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Substance-P receptor Ligand DA-5018 Family 14 73
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
Guanylate cyclase soluble subunit beta-1 Inhibitor Cinaciguat ... 7 50
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
5-hydroxytryptamine receptor 1A Ligand Robalzotan Family 9 41
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Histamine H3 receptor Ligand A-317920 Family 9 240
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 3 89
Galectin-3 Inhibitor 2,3,5,6-tetrafluoro-4-methoxy-benzamide F... 1 0
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Poly [ADP-ribose] polymerase 1 Inhibitor 3-methoxybenzamide Fa... 2 23
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 16
Voltage-dependent N-type calcium channel subunit alpha-1B Liga... 2 2
Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13
Plasmepsin-2 Inhibitor PS-662477 Family 7 55
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Peroxisome proliferator-activated receptor gamma and Peroxisom... 2 4
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 4-hy... 2 13
Histamine H3 receptor Ligand A-349821 Family 49 228
Interstitial collagenase Inhibitor N-hydroxy-4-(4-methoxy-phen... 6 4
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Angiopoietin-1 receptor and Cyclin-dependent kinase 1 Inhibito... 2 10
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Acetylcholinesterase and Cholinesterase Inhibitor Caproctamine... 7 17
Neutrophil elastase and Urokinase-type plasminogen activator I... 1 3
Neutrophil elastase Inhibitor N,n-bis(cyanomethyl)-3,4-dimetho... 3 30
Oxytocin receptor Ligand [mpa1, D-tyr(et)2, D-tic7]ot Family 43 26
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
Fatty-acid amide hydrolase 1 Inhibitor 4-(cyclohexylmethylcarb... 2 4
Urotensin-2 receptor Ligand SB-436811 Family 6 71
Histone deacetylase 1 Inhibitor N-hydroxy-8-(2-methoxyphenyl)-... 2 14
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Arachidonate 5-lipoxygenase Inhibitor 2-(4-butoxy-phenyl)-n-hy... 3 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 49 19
D(2) dopamine receptor Ligand Epidepride Family 31 66
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
Acetylcholinesterase Inhibitor 6-methyl-4-(4-benzoylpiperazin-... 2 6
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Peroxisome proliferator-activated receptor delta and Peroxisom... 20 8
Disintegrin and metalloproteinase domain-containing protein 17... 28 10
Neutrophil elastase inhibitor phenyl N-[(2S)-1-[(2S)-2-[[(3S)-... 10 4
Matrilysin and 72 kDa type IV collagenase inhibitor (3S,6R,7S)... 2 2
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 55 36
Neutrophil elastase inhibitor (2S)-N-[(3S)-6-benzamido-5,5-dif... 6 10
Integrin beta-3 and Integrin alpha-IIb inhibitor (2R)-2-(benze... 4 13
Leukotriene B4 receptor 1 ligand AGN-PC-00GEAR family 2 2
Renin inhibitor N-[(2S,4S,5S,7S)-7-[2-(1-acetylpiperidin-4-yl)... 2 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Disintegrin and metalloproteinase domain-containing protein 17... 2 0
Carbonic anhydrase 9 and Carbonic anhydrase 14 inhibitor N-[2-... 6 10
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 2 13
Prelamin-A/C and Beta-lactamase inhibitor CHEMBL1589265 family 1 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(4S)-3... 3 24
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Growth hormone secretagogue receptor type 1 ligand tert-butyl ... 5 4
Growth hormone secretagogue receptor type 1 ligand 2-(2-acetyl... 2 0
Growth hormone secretagogue receptor type 1 ligand 2-benzylsul... 2 0
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 2 6
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 3
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 7 18
Cytochrome P450 1A2 and Cytochrome P450 3A4 inhibitor 4-[4-[2-... 2 3
Integrin beta-3 and Integrin alpha-IIb inhibitor [(1R)-1-(benz... 3 0
Growth hormone secretagogue receptor type 1 ligand 2-[(2S)-1-[... 2 0
Bifunctional epoxide hydrolase 2 inhibitor 1-(1-adamantyl)-3-[... 2 0
Potassium voltage-gated channel subfamily H member 2 and Melan... 5 4
C-C chemokine receptor type 5 ligand 4-[4-[[4-[(5R)-3-cyclohex... 4 2
Histamine H3 receptor and Sodium-dependent serotonin transport... 4 2
Histamine H3 receptor and Sodium-dependent serotonin transport... 14 3
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 11
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 15
Disintegrin and metalloproteinase domain-containing protein 17... 2 0
Follicle-stimulating hormone receptor ligand SureCN6140614 family 2 8
Cathepsin S and Cathepsin L1 inhibitor benzyl N-[(2S)-1-oxo-1-... 2 2
Pol polyprotein inhibitor (3S)-N-tert-butyl-2-[(2R)-2-[(3S,6S,... 3 1
Stromelysin-1 and Interstitial collagenase inhibitor (2R)-2-[4... 4 1
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 0
C-C chemokine receptor type 5 ligand (4-chlorophenyl) N-[1-[(4... 2 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
D(3) dopamine receptor ligand S33084 family 1 1
72 kDa type IV collagenase and Interstitial collagenase inhibi... 2 0
Capsid scaffolding protein inhibitor AC1LAC52 family 1 0
Sodium- and chloride-dependent glycine transporter 1 inhibitor... 1 1
Caspase-3 inhibitor N-[(2-methoxyphenyl)methyl]-3-oxo-1,2-benz... 3 0
Transient receptor potential cation channel subfamily V member... 1 0
C-C chemokine receptor type 3 ligand SureCN3932025 family 1 1
Calpain-1 catalytic subunit inhibitor (3S)-3-[[4-[2-(methoxyme... 2 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00251136 CHEMBL197931 Bioactive AGN-PC-075XOP
CFAMM00251157 DNC005840 Investigative Drug 4-Butoxy-N-hydroxycarbamoylmethyl-benzamide
CFAMM00251165 DNC005842 Investigative Drug N-Hydroxycarbamoylmethyl-4-phenoxy-benzamide
CFAMM00251137 DNC005838 Investigative Drug N-Hydroxycarbamoylmethyl-4-methoxy-benzamide
CFAMM00251142 DNC014564 Investigative Drug N-(5-Hydroxycarbamoyl-pentyl)-4-methoxy-benzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27526 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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