CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1811
Family Name 5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine receptor 2B Ligand 3-(2-dimethylamino-ethyl)-1-methyl-1h-indol-4-ol Family
No. of Seeds 11 No. of Other Members 12
Family Centroid CFAMM00251230 Functional Category Investigative Drug
Superfamily Beta adrenergic receptor ligand monosubstituted indole derivative Pindolol Superfamily
Class Class 24

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
DNA Binder Primaquine Family 3 245
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Somatostatin receptor type 2 ligand octapeptide Lanreotide Family 93 156
DNA Binder Elliptinium Acetate Family 11 116
Citric Acid family 2 58
D(1B) dopamine receptor Ligand LE-300 Family 65 452
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 11 49
Apricoxib family 8 77
Indeglitazar family 3 39
Nicotinic acetylcholine receptor alpha2 / alpha3 Ligand Ibogai... 3 21
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 11 41
Tyrosine kinase Inhibitor PKI166 Family 17 198
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Plasminogen and Prothrombin Inhibitor 2-(2-hydroxy-phenyl)-1h-... 3 69
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor alpha and Platelet-der... 2 14
D(2) dopamine receptor and D(3) dopamine receptor Ligand L-741... 9 73
5-hydroxytryptamine receptor 2A Ligand [2-(6-methoxy-indol-1-y... 2 10
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Oestrogen receptor and Estrogen receptor beta Ligand ZK-119010... 2 16
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 2 0
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
Adenosine receptor A3 Ligand 4-methoxy-2-phenyl-2h-pyrazolo[4,... 9 49
D(2) dopamine receptor Ligand SLV-314 Family 19 69
Oestrogen receptor and Estrogen receptor beta Ligand 4-(3-phen... 5 14
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Acetylcholinesterase and Cholinesterase Inhibitor 6-hydroxy-1,... 4 2
Glycogen synthase kinase-3 beta Inhibitor 6-hydroxymanzamine A... 3 0
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-366... 5 75
DNA topoisomerase 1 Inhibitor 3-(4-phenyl-2,4'-bipyridin-6-yl)... 4 13
5-hydroxytryptamine receptor 2A and Alpha-2A adrenergic recept... 4 29
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand (6-ben... 2 5
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 38 35
Androgen receptor Ligand 11-methyl-6,11-dihydro-5h-benzo[a]car... 7 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 1
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 17 69
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 7 1
Kinesin-like protein KIF11 inhibitor AGN-PC-080PZM family 1 11
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 2 10
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 8 10
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 2 10
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 2 0
5-hydroxytryptamine receptor 6 ligand SureCN5502542 family 4 2
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-3-... 8 3
Glucagon receptor and Mitogen-activated protein kinase 14 liga... 6 5
5-hydroxytryptamine receptor 6 ligand 1-[9-(benzenesulfonyl)-6... 11 2
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 0
Glucocorticoid receptor ligand AGN-PC-0A9RHA family 1 2
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-00CFYH ... 2 1
5-hydroxytryptamine receptor 6 ligand SureCN5498885 family 5 4
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-09Q7W... 7 3
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 9 10
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 2 0
Retinoic acid receptor RXR-alpha ligand (E)-3-[3-(3,5-ditert-b... 5 5
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
Sodium-dependent serotonin transporter inhibitor SureCN6575591... 2 0
Sodium-dependent serotonin transporter inhibitor AGN-PC-075G9A... 3 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 10
Integrase inhibitor (Z)-4-[1-[(4-fluorophenyl)methyl]-5-methox... 1 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 1
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 1 1
Transient receptor potential cation channel subfamily V member... 1 5
Estrogen receptor beta and Estrogen receptor ligand 2-fluoro-4... 1 0
5-hydroxytryptamine receptor 2A ligand (3R,4R)-3-(2-phenyl-1H-... 1 18
Proto-oncogene tyrosine-protein kinase receptor Ret ligand Sur... 1 1
D(2) dopamine receptor and D(4) dopamine receptor ligand AGN-P... 1 0
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 1 2
Beta-3 adrenergic receptor ligand 3-[2-[[(2R)-2-(3-chloropheny... 1 1
Gonadotropin-releasing hormone receptor ligand SureCN7905635 f... 2 2
5-hydroxytryptamine receptor 6 ligand 1-[9-(2,5-dimethoxypheny... 2 0
Protein kinase C theta type and Protein kinase C delta type in... 10 7
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 7 1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 2 4
Androgen receptor ligand SureCN1990713 family 1 0
Coagulation factor VII and Tissue factor inhibitor 5-azaindole... 4 3
cAMP-dependent protein kinase catalytic subunit beta and cAMP-... 1 0
Carbonic anhydrase 2 inhibitor 6-hydroxy-1H-indole-2-sulfonami... 2 0
Kinesin-like protein KIF11 inhibitor AGN-PC-07R5ZC family 1 5
Estrogen receptor and Estrogen receptor beta ligand AGN-PC-074... 1 0
Aldose reductase and Aldo-keto reductase family 1 member B10 i... 1 2
Gamma-aminobutyric acid receptor subunit beta-3 and Gamma-amin... 2 0
Carbonic anhydrase 4 and Carbonic anhydrase 2 inhibitor 5,10-d... 3 1
Proto-oncogene tyrosine-protein kinase Src and cAMP-dependent ... 2 0
Indoles Metabolite 7-Hydroxyheptaphylline Family 4 0
Indoles Metabolite 6-Methoxy-3-(2-thiazolyl)-1H-indole Family 1 0
NP N-(1h-indol-6-yl)-3-(4-methoxy-1h-indol-1-yl)propanamide Fa... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00251229 DNC005857 Investigative Drug 3-(2-Pyrrolidin-1-yl-ethyl)-1H-indol-4-ol
CFAMM00251228 DNC005855 Investigative Drug 3-(2-Dimethylamino-ethyl)-2-methyl-1H-indol-4-ol
CFAMM00251227 DNC005854 Investigative Drug 3-(2-Dimethylamino-ethyl)-1H-indol-6-ol
CFAMM00251233 DNC005859 Investigative Drug 3-Dimethylaminomethyl-1-methyl-1H-indol-4-ol
CFAMM00251232 DNC005858 Investigative Drug 3-Dimethylaminomethyl-1H-indol-4-ol
CFAMM00251231 DNC005853 Investigative Drug 1-Butyl-3-(2-dimethylamino-ethyl)-1H-indol-4-ol
CFAMM00251230 DNC005852 Investigative Drug 3-(2-Dimethylamino-ethyl)-1-methyl-1H-indol-4-ol
CFAMM00251244 DNC005862 Investigative Drug 1-(2-Dimethylamino-ethyl)-1H-indol-4-ol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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