CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1813
Family Name Histamine H1 receptor Ligand MDL-105212 Family
No. of Seeds 16 No. of Other Members 56
Family Centroid CFAMM00251312 Functional Category Investigative Drug with Natural Product
Superfamily Neuromedin-K receptor and Substance-K receptor Ligand CS-003 Superfamily
Class Class 1077

Cousin Family NamesSeedsMembers
Leukotriene B4 receptor 1 Ligand Ltb 019 Family 3 35
Neuromedin-K receptor and Substance-K receptor Ligand CS-003 F... 2 14
Kappa-type opioid receptor Ligand Fedotozine Family 1 11
Histamine H3 receptor Ligand A-349821 Family 49 228
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Neutrophil elastase Inhibitor N,n-bis(cyanomethyl)-3,4-dimetho... 3 30
Urotensin-2 receptor Ligand SB-436811 Family 6 71
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 2 6
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor 2-[3-[(1R... 9 46
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL14038... 1 9
Prelamin-A/C and Retinal dehydrogenase 1 inhibitor CHEMBL15810... 1 1
Neuromedin-K receptor ligand AGN-PC-09QL9U family 1 3
Substance-K receptor and Substance-P receptor ligand AGN-PC-07... 1 0
Melanocortin receptor 4 ligand [(3R,4S)-4-(4-chlorophenyl)-1-p... 5 8
Kappa-type opioid receptor and Delta-type opioid receptor liga... 1 3
Cannabinoid receptor 1 ligand AGN-PC-03RV6L family 10 3
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 15
Substance-P receptor and Substance-K receptor ligand 4-bromo-N... 2 3
Substance-P receptor ligand 1-[3-(3,4-dichlorophenyl)-3-[2-(1'... 5 4
Substance-K receptor ligand AGN-PC-074GE0 family 1 0
Substance-P receptor and Substance-K receptor ligand AGN-PC-07... 1 1
Cholinesterase and Acetylcholinesterase inhibitor 3,4,5-trimet... 1 0
Substance-P receptor ligand AGN-PC-073LX9 family 1 0
Substance-K receptor and Substance-P receptor ligand N-[(2Z)-3... 1 0
Muscarinic acetylcholine receptor M3 ligand N-[[3-[3-[(3-methy... 5 2
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor AGN-PC-00... 5 14
Potassium voltage-gated channel subfamily H member 2 ligand 1-... 2 1
cGMP-specific 3',5'-cyclic phosphodiesterase and Calcium/calmo... 1 5
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor Tetracycl... 1 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN7... 1 1
NP (e)-4-methoxy-6,6-dimethyl-5-(2-oxo-4-(2,6,6-trimethylcyclo... 131 0
NP ((1r,4as,8as)-4a-hydroxy-1-(3,4,5-trimethoxyphenyl)octahydr... 3 3
(1R,5S)-3-(2-(3,4,5-trimethoxyphenyl)acetyl)-3,4,5,6-tetrahydr... 2 0
Putative NP ZINC08791780 Family 3 0
2-(2,4-dimethoxyphenyl)-2,3,6,7,11,12-hexahydro-[1,4]dioxepino... 3 0


External ID

Functional Category

Molecule Name

CFAMM00251279 CHEMBL36462 Bioactive N-[(2Z)-3-(3,4-dichlorophenyl)-5-(4-hydroxy-4-phenylpiperidin-1-yl)-2-methoxyiminopentyl]-3,4,5-trimethoxy-N-methylbenzamide
CFAMM00251291 CHEMBL176951 Bioactive AGN-PC-075ADI
CFAMM00251318 CHEMBL312173 Bioactive AGN-PC-074LOT
CFAMM00251311 CHEMBL553617 Bioactive [(3R)-3-(3,4-dichlorophenyl)-3-[2-[4-(4-methylpiperazine-1-carbonyl)-4-phenylpiperidin-1-yl]ethyl]pyrrolidin-1-yl]-(3,4,5-trimethoxyphenyl)methanone;hydrochloride
CFAMM00251304 CHEMBL310173 Bioactive AGN-PC-074LOU
CFAMM00251296 CHEMBL315814 Bioactive AGN-PC-074LJQ
CFAMM00251316 CHEMBL313931 Bioactive AGN-PC-074LNT
CFAMM00251321 CHEMBL540553 Bioactive [(3R)-3-(3,4-dichlorophenyl)-3-[2-[4-(morpholine-4-carbonyl)-4-phenylpiperidin-1-yl]ethyl]pyrrolidin-1-yl]-(3,4,5-trimethoxyphenyl)methanone;hydrochloride
CFAMM00251314 CHEMBL372587 Bioactive SureCN4208412
CFAMM00251293 CHEMBL539021 Bioactive AC1L4BI3
CFAMM00251312 DNC005873 Investigative Drug MDL-105212

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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