CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1819
Family Name Adenosine receptor A3 Ligand 2-(4-nitro-1h-benzo[d]imidazol-2-yl)quinoxaline Family
No. of Seeds 2 No. of Other Members 12
Family Centroid CFAMM00251476 Functional Category Investigative Drug
Superfamily Adenosine receptor A3 and Methionine aminopeptidase 2 Binder Superfamily
Class Class 2100

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1D Ligand Rizatriptan Family 7 460
Alpha-2 adrenergic receptor Ligand Dexmedetomidine Family 32 639
Toll-like receptor 7 Ligand Imiquimod Family 3 237
Alpha-2A adrenergic receptor Ligand Brimonidine Family 3 6
Amiloride-sensitive sodium channel subunit alpha Ligand Triamt... 8 98
Histamine H1 receptor Ligand Mizolastine Family 14 603
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Transient receptor potential cation channel subfamily V member... 15 457
Vascular endothelial growth factor Inhibitor PTC299 Family 6 145
Cyclin-dependent kinase 2 Inhibitor Seliciclib Family 29 292
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Tryptase Inhibitor Babim Family 12 90
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Glutamate receptor AMPA subtype Ligand YM872 Family 2 21
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... 13 14
Vascular endothelial growth factor receptor 2 Ligand 6-(1h-ben... 2 5
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Adenosine receptor A2a and Adenosine receptor A3 Ligand 5-buty... 3 18
Epidermal growth factor receptor Ligand N*4*-(3-bromo-phenyl)-... 7 11
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
Methionine aminopeptidase 2 Inhibitor 2-(pyridin-2-yl)-1h-benz... 6 19
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Telomerase reverse transcriptase Inhibitor HOE-33258 Family 10 33
Adenosine receptor A1 Ligand Phenyl-(9-phenyl-9h-purin-6-yl)-a... 7 12
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 1 9
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Alpha-1A adrenergic receptor Ligand A-315456 Family 7 17
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Adenosine receptor A3 and Dual specificity mitogen-activated p... 5 27
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
Indoleamine 2,3-dioxygenase 1 Inhibitor 3-(4h-imidazol-4-yl)be... 6 3
Aromatase Inhibitor NSC-356781 Family 3 10
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Farnesyl pyrophosphate synthase Inhibitor [2-(benzoimidazol-1-... 2 16
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-bromobenzyl... 3 0
Histamine H3 receptor Ligand 4-(2-(phenylamino)ethyl)-1h-imida... 5 16
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand N-(9h-... 5 2
Sodium-dependent serotonin transporter Inhibitor 6-nitroquipaz... 18 21
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... 3 13
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 7 3
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 9
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 3 12
Histamine H3 receptor ligand SureCN7853275 family 2 5
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 2 1
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 4 3
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 7 4
Vascular endothelial growth factor receptor 2 and Mitogen-acti... 2 2
C-C chemokine receptor type 5 ligand SureCN1573831 family 4 3
D(4) dopamine receptor and D(2) dopamine receptor ligand 4-met... 13 8
Nociceptin receptor and Kappa-type opioid receptor ligand 1-[1... 4 4
Histamine H4 receptor ligand (2Z)-5-chloro-2-[(1-methylpiperid... 2 8
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 5 0
Transient receptor potential M8 protein ligand 2-[(E)-2-(oxan-... 5 3
Lysosomal Pro-X carboxypeptidase inhibitor N-[(1S)-1-(5,6-dich... 3 21
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 1 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 3
Smoothened homolog and Sonic hedgehog protein inhibitor N-cycl... 3 2
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 3 0
Mitogen-activated protein kinase 14 inhibitor 6-[5-(2,4-difluo... 9 3
Histamine H4 receptor and Histamine H3 receptor ligand (E)-[(3... 4 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Cyclin-dependent kinase 1 inhibitor 4-[[4-(3H-benzimidazol-5-y... 1 0
Serine/threonine-protein kinase mTOR inhibitor 5-(2-amino-3H-b... 3 1
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 2 2
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 10 6
Platelet-derived growth factor receptor beta and Vascular endo... 5 12
Mitogen-activated protein kinase 14 inhibitor imidazole 81 family 2 1
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152398 family 16 1
Mitogen-activated protein kinase 14 inhibitor 6-[2-(2,6-difluo... 3 0
Tyrosine-protein kinase JAK1 and Aurora kinase A inhibitor CHE... 2 0
Cyclin-dependent kinase 1 and Proto-oncogene tyrosine-protein ... 5 13
LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-(3-cyanophenyl)-... 4 0
Gonadotropin-releasing hormone receptor ligand SureCN3275214 f... 5 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 4 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Cyclin-dependent kinase 2 inhibitor SureCN3549598 family 3 1
Gonadotropin-releasing hormone receptor ligand AGN-PC-00AWCA f... 1 0
Platelet-derived growth factor receptor beta and Fibroblast gr... 10 0
Melanin-concentrating hormone receptor 1 ligand SureCN3834858 ... 2 1
5-hydroxytryptamine receptor 3A ligand AGN-PC-077D8K family 3 1
5-hydroxytryptamine receptor 2B ligand SureCN1299053 family 1 1
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
Dihydrofolate reductase type 1 and Dihydrofolate reductase inh... 1 0
Histamine H3 receptor ligand AGN-PC-074FFM family 1 2
Nuclear receptor ROR-gamma and Neuropeptide S receptor ligand ... 1 0
Small conductance calcium-activated potassium channel protein ... 1 0
3-hydroxyacyl-CoA dehydrogenase type-2 and Retinal dehydrogena... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00251472 CHEMBL124927 Bioactive T5977978
CFAMM00251476 DNC005884 Investigative Drug 2-(4-nitro-1H-benzo[d]imidazol-2-yl)quinoxaline

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26839 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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