Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.
Cousin Family Names Seeds Members 5-hydroxytryptamine receptor 1B ligand triptan Almotriptan Family 8 438 D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720 5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171 Acetylcholinesterase Inhibitor Tacrine Family 12 515 Prostaglandin G/H synthase 2 Inhibitor Celecoxib Family 3 97 Solute carrier family 12 member 1 Inhibitor Torasemide Family 13 75 Histamine H1 receptor Ligand Triprolidine Family 19 316 Thromboxane A2 receptor Ligand Ramatroban Family 13 49 5-hydroxytryptamine receptor 6 Ligand SB-742457 Family 9 66 Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242 D(1B) dopamine receptor Ligand LE-300 Family 65 452 Rho-associated protein kinase 1 Inhibitor Rho-kinase Inhibitor... 6 39 Histone deacetylase 1 Inhibitor Resminostat Family 2 5 E7820 family 9 56 5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44 5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 6 17 Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70 D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 3 15 D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48 5-hydroxytryptamine receptor 2A Ligand 8-chloro-1,2,3,4-tetrah... 5 4 Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Indisu... 2 14 5-hydroxytryptamine receptor 6 Ligand E-6837 Family 22 44 5-hydroxytryptamine receptor 6 Ligand 4-(1h-indol-1-ylsulfonyl... 7 79 5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2 Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24 Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(thiophen... 9 66 Trypsin Inhibitor 1-benzyl-1h-indole-5-carboxamidine Family 4 3 5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 14 19 Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7 NF-kappa-B Inhibitor 9-chloro-5h-6-thia-4,5-diaza-chrysene 6,6... 3 27 NF-kappa-B Inhibitor 5-bromo-n-(quinolin-8-yl)thiophene-2-sulf... 2 5 NF-kappa-B Inhibitor 2-nitro-n-(quinolin-8-yl)benzenesulfonami... 2 3 Carbonic anhydrase 2 and Carbonic anhydrase 9 Inhibitor Quinol... 4 13 5-hydroxytryptamine receptor 6 Ligand 6-tosyl-1,2,3,4,5,6-hexa... 4 22 Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2 Prostaglandin G/H synthase 1 Inhibitor 1-(4-aminosulfonylpheny... 3 18 Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23 Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10 Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2 Prostaglandin G/H synthase 2 Inhibitor 2-(4-(methylsulfonyl)ph... 7 33 Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27 Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7 Motilin receptor and Cytochrome P450 2D6 ligand 7-[[6-(4-chlor... 2 1 Protein kinase C theta type and Protein kinase C delta type in... 7 17 Protein kinase C theta type and Protein kinase C delta type in... 16 8 Glucocorticoid receptor ligand N-[(3S)-3-[1-(4-fluorophenyl)in... 11 24 5-hydroxytryptamine receptor 6 ligand N-methyl-1-[(1R)-6-(1H-p... 3 0 5-hydroxytryptamine receptor 6 ligand AGN-PC-07ZA0N family 1 3 5-hydroxytryptamine receptor 6 ligand CHEMBL1950756 family 8 8 5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 1 11 Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 6 2 Cathepsin L1 inhibitor Bio2_000267 family 9 1 Cannabinoid receptor 2 ligand AGN-PC-09M5PW family 12 2 Cannabinoid receptor 2 ligand 1,1,1-trifluoro-N-[(2S)-6-(1-pyr... 2 1 Cellular tumor antigen p53 and Microtubule-associated protein ... 1 8 Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-... 5 10 Cellular tumor antigen p53 and Microtubule-associated protein ... 1 3 72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 4 5-hydroxytryptamine receptor 6 ligand AGN-PC-09QKIN family 2 9 Substance-K receptor and Cytochrome P450 2D6 ligand 158848-32-... 4 4 Glucocorticoid receptor ligand 2,4,6-trimethyl-N-[(2S)-1-[[6-m... 16 1 Progesterone receptor and Mineralocorticoid receptor ligand AG... 6 1 Mineralocorticoid receptor and Glucocorticoid receptor ligand ... 5 0 Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor 4-[2-(... 2 6 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 13 1 5-hydroxytryptamine receptor 2A ligand SureCN5215979 family 2 10 Bifunctional epoxide hydrolase 2 and Prostaglandin G/H synthas... 7 20 Bifunctional epoxide hydrolase 2 and Prostaglandin G/H synthas... 2 0 5-hydroxytryptamine receptor 6 ligand SureCN3411879 family 10 3 5-hydroxytryptamine receptor 6 and Muscarinic acetylcholine re... 7 3 5-hydroxytryptamine receptor 6 ligand 1-(4-chlorophenyl)sulfon... 8 4 Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 4 Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 12 0 Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 0 Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 0 Neuropeptide Y receptor type 5 ligand 2-indol-1-yl-N-[4-[(prop... 7 6 5-hydroxytryptamine receptor 6 ligand 9-(benzenesulfonyl)-N,N-... 7 1 5-hydroxytryptamine receptor 6 ligand 9-(benzenesulfonyl)-6-br... 5 1 5-hydroxytryptamine receptor 6 ligand 9-(benzenesulfonyl)-N,N-... 2 0 5-hydroxytryptamine receptor 6 ligand 9-(2-bromophenyl)sulfony... 2 0 Glutamate receptor ionotropic, NMDA 2B ligand N-[3-[2-(4-benzy... 2 0 Progesterone receptor ligand N-[4-(5-cyano-1-methylpyrrol-2-yl... 6 6 D(2) dopamine receptor and 5-hydroxytryptamine receptor 7 liga... 3 11 Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 4 D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 5 2 5-hydroxytryptamine receptor 6 ligand 5-[3-(2-aminoethyl)indol... 1 0 Glucocorticoid receptor ligand 1-[(4aS)-6-(4-tert-butylphenyl)... 27 3 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 2 5-hydroxytryptamine receptor 7 ligand 6-[(2R)-2-[2-(4-methylpi... 1 0 5-hydroxytryptamine receptor 6 ligand 3,4-dichloro-N-[3-[[(2R)... 5 0 Protein kinase C theta type and Protein kinase C delta type in... 4 5 CGMP-dependent protein kinase inhibitor 2-[[4-[5-(4-fluorophen... 1 0 Carbonic anhydrase 2 and Carbonic anhydrase 5A, mitochondrial ... 3 3 5-hydroxytryptamine receptor 6 and Cytochrome P450 3A4 ligand ... 6 0 Cannabinoid receptor 2 ligand 1-(benzenesulfonyl)-N-quinolin-3... 2 2 Prostaglandin G/H synthase 2 inhibitor SureCN6345015 family 6 1 Prostaglandin D2 receptor 2 ligand SureCN2516080 family 1 0 5-hydroxytryptamine receptor 6 ligand 2-[[(1Z)-1-[5-(benzenesu... 1 0 5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 0 5-hydroxytryptamine receptor 6 ligand 4-bromo-N-[3-[[(2S)-1-me... 4 0 Neuropeptide Y receptor type 5 and Neuropeptide Y receptor typ... 1 0
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAMM00251807
CHEMBL1672549
Bioactive
SureCN1630606 CFAMM00251806
CHEMBL1672544
Bioactive
AGN-PC-04QDXB CFAMM00251820
CHEMBL49598
Bioactive
AGN-PC-073Q9G CFAMM00251797
CHEMBL45977
Bioactive
2-(1-naphthalen-2-ylsulfonylindol-6-yl)-1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazine CFAMM00251811
CHEMBL46187
Bioactive
2-(1-naphthalen-1-ylsulfonylindol-6-yl)-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazine CFAMM00251817
CHEMBL298274
Bioactive
2-(1-naphthalen-1-ylsulfonylindol-6-yl)-1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazine CFAMM00251816
CHEMBL299569
Bioactive
2-[1-(4-methylphenyl)sulfonylindol-6-yl]-1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazine CFAMM00251802
CHEMBL45695
Bioactive
2-[1-(benzenesulfonyl)indol-6-yl]-1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazine CFAMM00251808
CHEMBL1672548
Bioactive
N-[1-[(2S)-butan-2-yl]-3-(4-cyanophenyl)indol-6-yl]methanesulfonamide CFAMM00251800
CHEMBL47691
Bioactive
AGN-PC-073Q8E CFAMM00251814
CHEMBL213407
Bioactive
AGN-PC-0763GZ CFAMM00251804
CHEMBL2012565
Bioactive
N-[9-(4-aminobutyl)-1-methylpyrido[3,4-b]indol-7-yl]methanesulfonamide CFAMM00251810
CHEMBL213800
Bioactive
AGN-PC-0763GY CFAMM00251799
CHEMBL1642413
Bioactive
AGN-PC-046DIT CFAMM00251805
CHEMBL1672543
Bioactive
AGN-PC-09QN4S CFAMM00251819
CHEMBL329075
Bioactive
AC1OCFJQ CFAMM00251803
CHEMBL368069
Bioactive
SureCN3156652 CFAMM00251815
CHEMBL362177
Bioactive
AGN-PC-075BVI CFAMM00251809
18789670
Patent Compound
SureCN5204149
Statistics of CFAM Database
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
How to cite our database
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering.
Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
Last update by
2014.08.29
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Dr.
Chen Yuzong
Deputy
Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore
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