Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database. Cousin Family Names Seeds Members 5-hydroxytryptamine receptor 1B ligand triptan Almotriptan Family 8 438 D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720 5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171 Acetylcholinesterase Inhibitor Tacrine Family 12 515 Prostaglandin G/H synthase 2 Inhibitor Celecoxib Family 3 97 Solute carrier family 12 member 1 Inhibitor Torasemide Family 13 75 Histamine H1 receptor Ligand Triprolidine Family 19 316 Thromboxane A2 receptor Ligand Ramatroban Family 13 49 5-hydroxytryptamine receptor 6 Ligand SB-742457 Family 9 66 Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242 D(1B) dopamine receptor Ligand LE-300 Family 65 452 Rho-associated protein kinase 1 Inhibitor Rho-kinase Inhibitor... 6 39 Histone deacetylase 1 Inhibitor Resminostat Family 2 5 E7820 family 9 56 5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44 5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 6 17 Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70 D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 3 15 D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48 5-hydroxytryptamine receptor 2A Ligand 8-chloro-1,2,3,4-tetrah... 5 4 Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Indisu... 2 14 5-hydroxytryptamine receptor 6 Ligand E-6837 Family 22 44 5-hydroxytryptamine receptor 6 Ligand 4-(1h-indol-1-ylsulfonyl... 7 79 5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2 Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24 Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(thiophen... 9 66 Trypsin Inhibitor 1-benzyl-1h-indole-5-carboxamidine Family 4 3 5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 14 19 Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7 NF-kappa-B Inhibitor 9-chloro-5h-6-thia-4,5-diaza-chrysene 6,6... 3 27 NF-kappa-B Inhibitor 5-bromo-n-(quinolin-8-yl)thiophene-2-sulf... 2 5 NF-kappa-B Inhibitor 2-nitro-n-(quinolin-8-yl)benzenesulfonami... 2 3 Carbonic anhydrase 2 and Carbonic anhydrase 9 Inhibitor Quinol... 4 13 5-hydroxytryptamine receptor 6 Ligand 6-tosyl-1,2,3,4,5,6-hexa... 4 22 Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2 Prostaglandin G/H synthase 1 Inhibitor 1-(4-aminosulfonylpheny... 3 18 Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23 Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10 Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2 Prostaglandin G/H synthase 2 Inhibitor 2-(4-(methylsulfonyl)ph... 7 33 Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27 Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7 Motilin receptor and Cytochrome P450 2D6 ligand 7-[[6-(4-chlor... 2 1 Protein kinase C theta type and Protein kinase C delta type in... 7 17 Protein kinase C theta type and Protein kinase C delta type in... 16 8 Glucocorticoid receptor ligand N-[(3S)-3-[1-(4-fluorophenyl)in... 11 24 5-hydroxytryptamine receptor 6 ligand N-methyl-1-[(1R)-6-(1H-p... 3 0 5-hydroxytryptamine receptor 6 ligand AGN-PC-07ZA0N family 1 3 5-hydroxytryptamine receptor 6 ligand CHEMBL1950756 family 8 8 5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 1 11 Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 6 2 Cathepsin L1 inhibitor Bio2_000267 family 9 1 Cannabinoid receptor 2 ligand AGN-PC-09M5PW family 12 2 Cannabinoid receptor 2 ligand 1,1,1-trifluoro-N-[(2S)-6-(1-pyr... 2 1 Cellular tumor antigen p53 and Microtubule-associated protein ... 1 8 Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-... 5 10 Cellular tumor antigen p53 and Microtubule-associated protein ... 1 3 72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 4 5-hydroxytryptamine receptor 6 ligand AGN-PC-09QKIN family 2 9 Substance-K receptor and Cytochrome P450 2D6 ligand 158848-32-... 4 4 Glucocorticoid receptor ligand 2,4,6-trimethyl-N-[(2S)-1-[[6-m... 16 1 Progesterone receptor and Mineralocorticoid receptor ligand AG... 6 1 Mineralocorticoid receptor and Glucocorticoid receptor ligand ... 5 0 Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor 4-[2-(... 2 6 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 13 1 5-hydroxytryptamine receptor 2A ligand SureCN5215979 family 2 10 Bifunctional epoxide hydrolase 2 and Prostaglandin G/H synthas... 7 20 Bifunctional epoxide hydrolase 2 and Prostaglandin G/H synthas... 2 0 5-hydroxytryptamine receptor 6 ligand SureCN3411879 family 10 3 5-hydroxytryptamine receptor 6 and Muscarinic acetylcholine re... 7 3 5-hydroxytryptamine receptor 6 ligand 1-(4-chlorophenyl)sulfon... 8 4 Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 4 Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 12 0 Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 0 Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 0 Neuropeptide Y receptor type 5 ligand 2-indol-1-yl-N-[4-[(prop... 7 6 5-hydroxytryptamine receptor 6 ligand 9-(benzenesulfonyl)-N,N-... 7 1 5-hydroxytryptamine receptor 6 ligand 9-(benzenesulfonyl)-6-br... 5 1 5-hydroxytryptamine receptor 6 ligand 9-(benzenesulfonyl)-N,N-... 2 0 5-hydroxytryptamine receptor 6 ligand 9-(2-bromophenyl)sulfony... 2 0 Glutamate receptor ionotropic, NMDA 2B ligand N-[3-[2-(4-benzy... 2 0 Progesterone receptor ligand N-[4-(5-cyano-1-methylpyrrol-2-yl... 6 6 D(2) dopamine receptor and 5-hydroxytryptamine receptor 7 liga... 3 11 Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 4 D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 5 2 5-hydroxytryptamine receptor 6 ligand 5-[3-(2-aminoethyl)indol... 1 0 Glucocorticoid receptor ligand 1-[(4aS)-6-(4-tert-butylphenyl)... 27 3 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 2 5-hydroxytryptamine receptor 7 ligand 6-[(2R)-2-[2-(4-methylpi... 1 0 5-hydroxytryptamine receptor 6 ligand 3,4-dichloro-N-[3-[[(2R)... 5 0 Protein kinase C theta type and Protein kinase C delta type in... 4 5 CGMP-dependent protein kinase inhibitor 2-[[4-[5-(4-fluorophen... 1 0 Carbonic anhydrase 2 and Carbonic anhydrase 5A, mitochondrial ... 3 3 5-hydroxytryptamine receptor 6 and Cytochrome P450 3A4 ligand ... 6 0 Cannabinoid receptor 2 ligand 1-(benzenesulfonyl)-N-quinolin-3... 2 2 Prostaglandin G/H synthase 2 inhibitor SureCN6345015 family 6 1 Prostaglandin D2 receptor 2 ligand SureCN2516080 family 1 0 5-hydroxytryptamine receptor 6 ligand 2-[[(1Z)-1-[5-(benzenesu... 1 0 5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 0 5-hydroxytryptamine receptor 6 ligand 4-bromo-N-[3-[[(2S)-1-me... 4 0 Neuropeptide Y receptor type 5 and Neuropeptide Y receptor typ... 1 0
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAMM00251806 CHEMBL1672544 Bioactive
AGN-PC-04QDXB CFAMM00251816 CHEMBL299569 Bioactive
2-[1-(4-methylphenyl)sulfonylindol-6-yl]-1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazine CFAMM00251808 CHEMBL1672548 Bioactive
N-[1-[(2S)-butan-2-yl]-3-(4-cyanophenyl)indol-6-yl]methanesulfonamide CFAMM00251797 CHEMBL45977 Bioactive
2-(1-naphthalen-2-ylsulfonylindol-6-yl)-1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazine CFAMM00251807 CHEMBL1672549 Bioactive
SureCN1630606 CFAMM00251820 CHEMBL49598 Bioactive
AGN-PC-073Q9G CFAMM00251802 CHEMBL45695 Bioactive
2-[1-(benzenesulfonyl)indol-6-yl]-1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazine CFAMM00251811 CHEMBL46187 Bioactive
2-(1-naphthalen-1-ylsulfonylindol-6-yl)-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazine CFAMM00251800 CHEMBL47691 Bioactive
AGN-PC-073Q8E CFAMM00251817 CHEMBL298274 Bioactive
2-(1-naphthalen-1-ylsulfonylindol-6-yl)-1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazine CFAMM00251810 CHEMBL213800 Bioactive
AGN-PC-0763GY CFAMM00251814 CHEMBL213407 Bioactive
AGN-PC-0763GZ CFAMM00251804 CHEMBL2012565 Bioactive
N-[9-(4-aminobutyl)-1-methylpyrido[3,4-b]indol-7-yl]methanesulfonamide CFAMM00251799 CHEMBL1642413 Bioactive
AGN-PC-046DIT CFAMM00251815 CHEMBL362177 Bioactive
AGN-PC-075BVI CFAMM00251805 CHEMBL1672543 Bioactive
AGN-PC-09QN4S CFAMM00251803 CHEMBL368069 Bioactive
SureCN3156652 CFAMM00251819 CHEMBL329075 Bioactive
AC1OCFJQ CFAMM00251809 18789670 Patent Compound
SureCN5204149
Statistics of CFAM Database
490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
How to cite our database
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering.
Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
Last update by
2014.08.29
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Dr.
Chen Yuzong Deputy
Director of Center for Computational Science and Engineering All rights reserved.
