CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1839
Family Name 5-hydroxytryptamine receptor 6 Ligand 4-(1h-indol-1-ylsulfonyl)benzenamine Family
No. of Seeds 7 No. of Other Members 79
Family Centroid CFAMM00251863 Functional Category Investigative Drug
Superfamily 5-hydroxytryptamine receptor 6 and Hepatocyte growth factor receptor Binder Superfamily
Class Class 2264

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B ligand triptan Almotriptan Family 8 438
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
Acetylcholinesterase Inhibitor Tacrine Family 12 515
Prostaglandin G/H synthase 2 Inhibitor Etoricoxib Family 2 99
Solute carrier family 12 member 1 Inhibitor Torasemide Family 13 75
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
Thromboxane A2 receptor Ligand Ramatroban Family 13 49
5-hydroxytryptamine receptor 6 Ligand SB-742457 Family 9 66
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
D(1B) dopamine receptor Ligand LE-300 Family 65 452
Rho-associated protein kinase 1 Inhibitor Rho-kinase Inhibitor... 6 39
Histone deacetylase 1 Inhibitor Resminostat Family 2 5
E7820 family 9 56
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
Nicotinic acetylcholine receptor Ligand Epibatidine Family 36 19
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 6 17
5-hydroxytryptamine receptor 2B Ligand Sb 206553 Family 14 21
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 3 15
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Platelet-derived growth factor receptor alpha and Platelet-der... 5 48
Potassium voltage-gated channel subfamily H member 2 Ligand 5-... 5 14
5-hydroxytryptamine receptor 2A Ligand 8-chloro-1,2,3,4-tetrah... 5 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 19
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Indisu... 2 14
5-hydroxytryptamine receptor 6 Ligand E-6837 Family 22 44
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 16
5-hydroxytryptamine receptor 6 Ligand 4-(4,6-dinitro-1h-indol-... 4 19
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(thiophen... 9 66
D(2) dopamine receptor and D(3) dopamine receptor Ligand 1-(4-... 10 48
Trypsin Inhibitor 1-benzyl-1h-indole-5-carboxamidine Family 4 3
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 14 19
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
NF-kappa-B Inhibitor 9-chloro-5h-6-thia-4,5-diaza-chrysene 6,6... 3 27
NF-kappa-B Inhibitor 5-bromo-n-(quinolin-8-yl)thiophene-2-sulf... 2 5
NF-kappa-B Inhibitor 2-nitro-n-(quinolin-8-yl)benzenesulfonami... 2 3
Corticosteroid 11-beta-dehydrogenase isozyme 1 Inhibitor 2-(4-... 8 25
Carbonic anhydrase 2 and Carbonic anhydrase 9 Inhibitor Quinol... 4 13
5-hydroxytryptamine receptor 6 Ligand 6-tosyl-1,2,3,4,5,6-hexa... 4 22
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Acetylcholinesterase and Cholinesterase Inhibitor 1,9-bis(pyri... 8 38
Prostaglandin G/H synthase 1 Inhibitor 1-(4-aminosulfonylpheny... 3 18
Kinesin-like protein KIF11 Inhibitor 2-(trifluoromethyl)-9h-ca... 5 0
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Cytochrome P450 11B1, mitochondrial Inhibitor 2-methyl-1,2-di-... 8 15
Translocator protein Inhibitor 5-phenyl-6-thia-10b-aza-benzo[e... 1 2
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Metabotropic glutamate receptor 5 Ligand 5-(2-methylquinolin-7... 4 3
Metabotropic glutamate receptor 5 Ligand 7-m-tolyl-1,6-naphthy... 4 2
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Prostaglandin G/H synthase 2 Inhibitor 2-(4-(methylsulfonyl)ph... 7 33
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Prostaglandin G/H synthase 2 Inhibitor 1-(4-(methylsulfonyl)ph... 1 2
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
C-C chemokine receptor type 5 ligand AC1LAJBP family 2 6
Motilin receptor and Cytochrome P450 2D6 ligand 7-[[6-(4-chlor... 2 1
Protein kinase C theta type and Protein kinase C delta type in... 7 17
Glucocorticoid receptor ligand N-[(3S)-3-[1-(4-fluorophenyl)in... 11 24
5-hydroxytryptamine receptor 6 ligand N-methyl-1-[(1R)-6-(1H-p... 3 0
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 3
5-hydroxytryptamine receptor 6 ligand AGN-PC-07ZA0N family 1 3
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 10 2
5-hydroxytryptamine receptor 6 ligand CHEMBL1950756 family 8 8
5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 1 11
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 6 2
Cathepsin L1 inhibitor Bio2_000267 family 9 1
Progesterone receptor and Androgen receptor ligand 5-[4-[(Z)-C... 2 5
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 11 20
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 1
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2C lig... 2 3
Cannabinoid receptor 2 ligand AGN-PC-09M5PW family 12 2
Cannabinoid receptor 2 ligand 1,1,1-trifluoro-N-[(1R)-1-[4-[1-... 2 1
Cannabinoid receptor 2 ligand 1,1,1-trifluoro-N-[(2S)-6-(1-pyr... 2 1
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 8
Survival motor neuron protein and 15-hydroxyprostaglandin dehy... 1 35
Beta-3 adrenergic receptor and Beta-2 adrenergic receptor liga... 4 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-... 5 10
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 8
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 3
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 4
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 1
5-hydroxytryptamine receptor 6 ligand AGN-PC-09QKIN family 2 9
Substance-K receptor and Cytochrome P450 2D6 ligand 158848-32-... 4 4
Glucocorticoid receptor ligand 2,4,6-trimethyl-N-[(2S)-1-[[6-m... 16 1
Progesterone receptor and Mineralocorticoid receptor ligand AG... 6 1
Mineralocorticoid receptor and Glucocorticoid receptor ligand ... 5 0
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor 4-[2-(... 2 6
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 13 1
5-hydroxytryptamine receptor 2A ligand SureCN5215979 family 2 10
5-hydroxytryptamine receptor 6 ligand SureCN3147604 family 7 6
Sigma non-opioid intracellular receptor 1 ligand SureCN7434677... 1 0
5-hydroxytryptamine receptor 6 ligand SureCN3411879 family 10 3
5-hydroxytryptamine receptor 6 and Muscarinic acetylcholine re... 7 3
5-hydroxytryptamine receptor 6 ligand 1-(4-chlorophenyl)sulfon... 8 4
Carbonic anhydrase 12 and Carbonic anhydrase 9 inhibitor 4-(4-... 1 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 4
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 12 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 0
Prostaglandin D2 receptor 2 ligand 2-[5-fluoro-2-methyl-3-[(4-... 3 5
5-hydroxytryptamine receptor 6 ligand 1-(5-bromothiophen-2-yl)... 4 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 0
Metabotropic glutamate receptor 5 ligand AGN-PC-00CRVW family 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 5 5
Neuropeptide Y receptor type 5 ligand 2-indol-1-yl-N-[4-[(prop... 7 6
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 5 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 4 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 4 0
D(4) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 1
5-hydroxytryptamine receptor 6 ligand 9-(benzenesulfonyl)-N,N-... 7 1
5-hydroxytryptamine receptor 6 ligand 9-(benzenesulfonyl)-6-br... 5 1
5-hydroxytryptamine receptor 6 ligand 9-(benzenesulfonyl)-N,N-... 2 0
5-hydroxytryptamine receptor 6 ligand 9-(2-bromophenyl)sulfony... 2 0
Glutamate receptor ionotropic, NMDA 2B ligand N-[3-[2-(4-benzy... 2 0
Progesterone receptor ligand N-[4-(5-cyano-1-methylpyrrol-2-yl... 6 6
D(2) dopamine receptor and 5-hydroxytryptamine receptor 7 liga... 3 11
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 4
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 5 2
5-hydroxytryptamine receptor 6 ligand 5-[3-(2-aminoethyl)indol... 1 0
Prostaglandin G/H synthase 2 inhibitor 1-(3,4-difluorophenyl)-... 1 3
Carbonic anhydrase 2 and Carbonic anhydrase 12 inhibitor 5-[1-... 7 5
Glucocorticoid receptor ligand 1-[(4aS)-6-(4-tert-butylphenyl)... 27 3
Hepatocyte growth factor receptor and Protein-tyrosine kinase ... 2 15
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2C lig... 1 0
Sodium-dependent serotonin transporter and D(2) dopamine recep... 1 0
Tyrosine-protein kinase Yes and Proto-oncogene tyrosine-protei... 7 18
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 2
Carbonic anhydrase 2 and Carbonic anhydrase 1 inhibitor 2-(2,6... 3 10
5-hydroxytryptamine receptor 7 ligand 6-[(2R)-2-[2-(4-methylpi... 1 0
5-hydroxytryptamine receptor 1D ligand AGN-PC-01NTBS family 1 1
5-hydroxytryptamine receptor 6 ligand 3,4-dichloro-N-[3-[[(2R)... 5 0
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 1 1
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 2 0
CGMP-dependent protein kinase inhibitor 2-[[4-[5-(4-fluorophen... 1 0
Carbonic anhydrase 2 and Carbonic anhydrase 5A, mitochondrial ... 3 3
5-hydroxytryptamine receptor 6 and Cytochrome P450 3A4 ligand ... 6 0
Cannabinoid receptor 2 ligand 1-(benzenesulfonyl)-N-quinolin-3... 2 2
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 1,1,1... 12 3
Thromboxane A2 receptor ligand 3-[5-[(4-chlorophenyl)sulfonyla... 1 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor [1-[4... 2 0
Prostaglandin G/H synthase 2 inhibitor AGN-PC-03NCPN family 4 0
Prostaglandin G/H synthase 2 inhibitor SureCN6345015 family 6 1
Prostaglandin G/H synthase 2 inhibitor AGN-PC-03NCPD family 6 2
Thromboxane-A synthase inhibitor AGN-PC-07BYVF family 1 0
Prostaglandin D2 receptor 2 ligand SureCN2516080 family 1 0
Sodium-dependent noradrenaline transporter and Sodium-dependen... 5 7
5-hydroxytryptamine receptor 6 ligand 2-[[(1Z)-1-[5-(benzenesu... 1 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 0
5-hydroxytryptamine receptor 6 ligand 4-bromo-N-[3-[[(2S)-1-me... 4 0
Squalene synthase inhibitor AGN-PC-00ONKT family 1 0
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 1 0
Neuropeptide Y receptor type 5 and Neuropeptide Y receptor typ... 1 0
Cytochrome P450 3A4 inhibitor N-[2-fluoro-4-(4-fluorophenyl)ph... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00251865 CHEMBL94422 Bioactive AGN-PC-00EUD8
CFAMM00251888 CHEMBL94093 Bioactive 4-[3-[2-(dimethylamino)ethyl]indol-1-yl]sulfonylaniline
CFAMM00251900 CHEMBL329739 Bioactive AGN-PC-074QTD
CFAMM00251906 CHEMBL112296 Bioactive AGN-PC-04A0QA
CFAMM00251863 DNC005950 Investigative Drug 4-(1H-indol-1-ylsulfonyl)benzenamine
CFAMM00251871 DNC014441 Investigative Drug 1-(4-(methylsulfonyl)phenyl)-1H-indole

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26388 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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