CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1847
Family Name Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluoromethyl)benzyl)-4-phenoxybenzamide Family
No. of Seeds 8 No. of Other Members 39
Family Centroid CFAMM00252100 Functional Category Investigative Drug with Human Metabolite
Superfamily Neutrophil elastase and D(2) dopamine receptor Binder Superfamily
Class Class 1766

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Sodium channel protein type 5 subunit alpha Ligand Dyclonine F... 6 174
Sodium channel protein type 5 subunit alpha Ligand Flecainide ... 2 162
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Glycoprotein IIb/IIIa receptor Ligand Tirofiban Family 4 173
Peroxisome proliferator-activated receptor alpha Ligand Bezafi... 2 17
Zucapsacin family 7 177
Cholesteryl ester transfer protein Inhibitor Anacetrapib Family 3 63
Leukotriene B4 receptor 1 Ligand Ltb 019 Family 3 35
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
C-C chemokine receptor type 5 Ligand GW873140 Family 6 78
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Substance-P receptor Ligand DA-5018 Family 14 73
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 23
Microsomal triglyceride transfer protein large subunit Inhibit... 3 103
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Guanylate cyclase soluble subunit beta-1 Inhibitor Cinaciguat ... 7 50
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
5-hydroxytryptamine receptor 1A Ligand Robalzotan Family 9 41
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Histamine H3 receptor Ligand A-317920 Family 9 240
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 3 89
Poly [ADP-ribose] polymerase 1 Inhibitor 3-methoxybenzamide Fa... 2 23
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 16
Voltage-dependent N-type calcium channel subunit alpha-1B Liga... 2 2
Plasmepsin-2 Inhibitor PS-662477 Family 7 55
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Leukotriene B4 receptor 1 Ligand SC-51146 Family 6 315
Peroxisome proliferator-activated receptor gamma and Peroxisom... 2 4
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 4-hy... 2 13
Histamine H3 receptor Ligand A-349821 Family 49 228
Acetylcholinesterase and Cholinesterase Inhibitor 3-[7-(benzyl... 22 303
Interstitial collagenase Inhibitor N-hydroxycarbamoylmethyl-4-... 5 24
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Angiopoietin-1 receptor and Cyclin-dependent kinase 1 Inhibito... 2 10
Caspase-3 Inhibitor 2-(4-methoxy-benzyl)isoquinoline-1,3,4-tri... 2 2
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Acetylcholinesterase and Cholinesterase Inhibitor Caproctamine... 7 17
Neutrophil elastase and Urokinase-type plasminogen activator I... 1 3
Neutrophil elastase Inhibitor N,n-bis(cyanomethyl)-3,4-dimetho... 3 30
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 33
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
Fatty-acid amide hydrolase 1 Inhibitor 4-(cyclohexylmethylcarb... 2 4
Urotensin-2 receptor Ligand SB-436811 Family 6 71
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 10 15
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Arachidonate 5-lipoxygenase Inhibitor 2-(4-butoxy-phenyl)-n-hy... 3 9
D(2) dopamine receptor Ligand Epidepride Family 31 66
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 3
Acetylcholinesterase Inhibitor 6-methyl-4-(4-benzoylpiperazin-... 2 6
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Peroxisome proliferator-activated receptor delta and Peroxisom... 20 8
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 2 0
Matrilysin and 72 kDa type IV collagenase inhibitor (3S,6R,7S)... 2 2
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 55 36
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 8 12
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 6 19
Neutrophil elastase inhibitor (2S)-N-[(3S)-6-benzamido-5,5-dif... 6 10
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[(3... 2 11
Histamine H3 receptor ligand 1-(4-pentan-3-ylpiperazin-1-yl)-2... 1 1
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 3 2
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 10 8
Prothrombin inhibitor N-cyclohexyl-3-[3-(diaminomethylideneami... 3 4
Leukotriene B4 receptor 1 ligand AGN-PC-00GEAR family 2 2
Renin inhibitor N-[(2S,4S,5S,7S)-7-[2-(1-acetylpiperidin-4-yl)... 2 1
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 3 10
Lethal(3)malignant brain tumor-like protein 1 and Lysine-speci... 1 6
Substance-P receptor ligand AGN-PC-075NP5 family 4 8
Mu-type opioid receptor ligand 3-[(3R,4R)-1-[(2,4-dimethoxyphe... 2 4
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 2
Carbonic anhydrase 9 and Carbonic anhydrase 14 inhibitor N-[2-... 6 10
Prelamin-A/C and Retinal dehydrogenase 1 inhibitor CHEMBL15810... 1 1
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 2 13
Prelamin-A/C and Beta-lactamase inhibitor CHEMBL1589265 family 1 0
Rho-associated protein kinase 1 and Rho-associated protein kin... 1 7
Prostaglandin D2 receptor 2 and Prostaglandin D2 receptor liga... 12 0
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Growth hormone secretagogue receptor type 1 ligand 2-(2-acetyl... 2 0
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 2 6
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 3
Orexin receptor type 1 and Orexin receptor type 2 ligand [(2S)... 3 1
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 7 18
Prostaglandin E2 receptor EP4 subtype ligand 4-[(1S)-1-[[2-(tr... 2 1
Collagenase 3 and 72 kDa type IV collagenase inhibitor N-[(3,4... 1 6
Cytochrome P450 1A2 and Cytochrome P450 3A4 inhibitor 4-[4-[2-... 2 3
Prostaglandin D2 receptor 2 and Chemoattractant receptor-homol... 1 1
Integrin beta-3 and Integrin alpha-IIb inhibitor [(1R)-1-(benz... 3 0
Nociceptin receptor and Kappa-type opioid receptor ligand AGN-... 1 3
Bifunctional epoxide hydrolase 2 inhibitor 1-(1-adamantyl)-3-[... 2 0
Potassium voltage-gated channel subfamily H member 2 and Melan... 5 4
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 15 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 3
Estrogen receptor ligand 2-(3-hydroxy-6-oxoxanthen-9-yl)-5-[[4... 1 2
Peroxisome proliferator-activated receptor delta and Peroxisom... 13 0
C-C chemokine receptor type 5 ligand 4-[4-[[4-[(5R)-3-cyclohex... 4 2
Histamine H3 receptor and Sodium-dependent serotonin transport... 4 2
Histamine H3 receptor and Sodium-dependent serotonin transport... 14 3
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 2 6
Histamine H3 receptor and Sodium-dependent serotonin transport... 8 0
Cannabinoid receptor 1 ligand AGN-PC-03RV6L family 10 3
Caspase-1 inhibitor (3S)-3-[2-[3-(naphthalene-1-carbonylamino)... 13 5
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(3... 2 2
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 11
Pol polyprotein inhibitor AC1LA3AI family 5 9
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 15
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 3 1
Pol polyprotein inhibitor (3S)-N-tert-butyl-2-[(2R)-2-[(3S,6S,... 3 1
Coagulation factor X inhibitor 3-[4-[[(E)-3-[3-(diaminomethyli... 4 6
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 2
Melanin-concentrating hormone receptor 1 ligand N-methyl-N-[(3... 2 2
Beta-secretase 1 inhibitor 1-N-[(2S,3R)-1-(3,5-difluorophenyl)... 8 7
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 16 2
C-C chemokine receptor type 5 ligand (4-chlorophenyl) N-[1-[(4... 2 2
Free fatty acid receptor 1 ligand (3R,4R)-3-[4-(3,4-dimethylph... 4 4
Dipeptidyl peptidase 4 inhibitor SureCN5777647 family 1 0
Muscarinic acetylcholine receptor M3 ligand N-[[3-[3-[(3-methy... 5 2
Neuropeptide Y receptor type 1 and Sodium-dependent serotonin ... 2 7
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
D(3) dopamine receptor ligand S33084 family 1 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(2-chlo... 2 4
Arachidonate 5-lipoxygenase inhibitor methyl 5-[1-(2-butyl-1-b... 2 4
Survival motor neuron protein and Muscleblind-like protein 1 i... 1 10
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 4 3
Prostaglandin E synthase inhibitor AGN-PC-09QKN6 family 1 3
Trace amine-associated receptor 1 ligand SureCN13886619 family 1 1
Sodium- and chloride-dependent glycine transporter 1 inhibitor... 1 1
Cathepsin K inhibitor benzyl N-[(2S)-4-methyl-1-oxo-1-[2-[[(4-... 2 0
Arachidonate 5-lipoxygenase and Arachidonate 15-lipoxygenase i... 1 2
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 2 3
Glutamate carboxypeptidase 2 inhibitor 2-(4-hydroxy-3-methoxyp... 1 4
Transient receptor potential cation channel subfamily V member... 1 0
C-C chemokine receptor type 3 ligand SureCN3932025 family 1 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-[(4... 1 0
Putative NP ZINC02127056 Family 4 1
Putative NP ZINC04061066 Family 18 0
Putative NP ZINC20611663 Family 4 0
Putative NP ZINC02099241 Family 12 0
Putative NP ZINC00519603 Family 8 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00252095 CHEMBL249291 Bioactive SureCN5521806
CFAMM00252083 CHEMBL249311 Bioactive SureCN5526168
CFAMM00252096 DNC007804 Investigative Drug 4-(4-((phenethylamino)methyl)phenoxy)benzamide
CFAMM00252103 DNC005983 Investigative Drug N-(3-(trifluoromethoxy)benzyl)-4-phenoxybenzamide
CFAMM00252102 DNC005982 Investigative Drug N-(3-(trifluoromethyl)benzyl)-4-phenoxybenzamide
CFAMM00252101 DNC005985 Investigative Drug N-(4-methyl-benzyl)-4-phenoxy-benzamide
CFAMM00252100 DNC005984 Investigative Drug N-(4-(trifluoromethyl)benzyl)-4-phenoxybenzamide
CFAMM00252104 DNC013450 Investigative Drug N-(3-phenethoxybenzyl)-4-hydroxybenzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27270 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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