CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1849
Family Name Oestrogen receptor and Estrogen receptor beta Ligand 4-(3-phenyl-1h-indol-2-yl)phenol Family
No. of Seeds 5 No. of Other Members 14
Family Centroid CFAMM00252146 Functional Category Investigative Drug with Natural Product
Superfamily Androgen receptor and Oestrogen receptor Binder Superfamily
Class Class 1404

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Phospholipase A2 Inhibitor Quinacrine Family 13 95
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Temoporfin family 1 3
DNA Binder Elliptinium Acetate Family 11 116
Citric Acid family 2 58
Apricoxib family 8 77
Indeglitazar family 3 39
Nicotinic acetylcholine receptor alpha2 / alpha3 Ligand Ibogai... 3 21
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 11 41
Cytochrome b Inhibitor 2-nonyl-4-hydroxyquinoline N-OXIDE Family 2 22
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Acetylcholinesterase Inhibitor Velnacrine Family 2 29
Plasminogen and Prothrombin Inhibitor 2-(2-hydroxy-phenyl)-1h-... 3 69
D(2) dopamine receptor and D(3) dopamine receptor Ligand L-741... 9 73
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Oestrogen receptor and Estrogen receptor beta Ligand ZK-119010... 2 16
Adenosine receptor A3 Ligand 4-methoxy-2-phenyl-2h-pyrazolo[4,... 9 49
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 11 12
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 8 8
Platelet-derived growth factor receptor alpha and Platelet-der... 2 13
Acetylcholinesterase and Cholinesterase Inhibitor 6-hydroxy-1,... 4 2
Glycogen synthase kinase-3 beta Inhibitor 6-hydroxymanzamine A... 3 0
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3,3'-pyrazine-2,5-... 2 14
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-366... 5 75
Indoleamine 2,3-dioxygenase 1 Inhibitor 5-aminoquinolin-8-ol F... 3 16
DNA topoisomerase 1 Inhibitor 3-(4-phenyl-2,4'-bipyridin-6-yl)... 4 13
5-hydroxytryptamine receptor 2A and Alpha-2A adrenergic recept... 4 29
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 38 35
Androgen receptor Ligand 11-methyl-6,11-dihydro-5h-benzo[a]car... 7 9
Metabotropic glutamate receptor 5 Ligand 3-hydroxy-5-(2-methyl... 2 1
Prostaglandin G/H synthase 2 Inhibitor 5-methoxy-2-(4-(methyls... 3 12
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 1
Kinesin-like protein KIF11 inhibitor AGN-PC-080PZM family 1 11
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 2 10
Vascular endothelial growth factor receptor 2 ligand indolyl q... 4 3
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 8 10
Renin inhibitor SureCN1144364 family 3 15
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 2 10
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 2 0
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 2 21
Prelamin-A/C inhibitor 1-[(3,4-dimethoxyphenethyl)amino]-3-(1H... 1 2
Hypoxia-inducible factor 1-alpha and Lethal factor inhibitor C... 1 1
Gonadotropin-releasing hormone receptor ligand AGN-PC-075RJQ f... 3 0
Androgen receptor ligand (6R,7S)-6-ethyl-7-methyl-4-(trifluoro... 22 29
5-hydroxytryptamine receptor 6 ligand 1-[9-(benzenesulfonyl)-6... 11 2
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 2 1
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-09Q7W... 7 3
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 10
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 5
Coagulation factor VII inhibitor AGN-PC-0763KB family 1 1
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 11 1
Estrogen receptor ligand 4-[3,5-bis(4-hydroxyphenyl)-1-propylp... 1 0
Transient receptor potential cation channel subfamily V member... 1 5
Estrogen receptor beta and Estrogen receptor ligand 2-fluoro-4... 1 0
Beta-2 adrenergic receptor ligand SureCN5346426 family 8 0
5-hydroxytryptamine receptor 2A ligand (3R,4R)-3-(2-phenyl-1H-... 1 18
Proto-oncogene tyrosine-protein kinase receptor Ret ligand Sur... 1 1
5-hydroxytryptamine receptor 6 ligand 2-methyl-5-(2-nitropheno... 1 6
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
D(2) dopamine receptor and D(4) dopamine receptor ligand AGN-P... 1 0
D(1A) dopamine receptor and D(2) dopamine receptor ligand (6aR... 3 6
Gonadotropin-releasing hormone receptor ligand SureCN7905635 f... 2 2
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Coagulation factor X and Urokinase-type plasminogen activator ... 8 10
Coagulation factor VII and Tissue factor inhibitor 2-[3-(5-car... 3 2
Coagulation factor X and Prothrombin inhibitor SureCN6434488 f... 3 13
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 2
Estrogen receptor and Estrogen receptor beta ligand SureCN6841... 2 5
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-077PJ... 4 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 23 5
Coagulation factor X and Prothrombin inhibitor SureCN6292901 f... 2 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 7 1
Urokinase-type plasminogen activator and Tissue-type plasminog... 1 4
D(1A) dopamine receptor and D(2) dopamine receptor ligand (6aS... 2 1
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 2 8
Carbonic anhydrase 2 inhibitor 6-hydroxy-1H-indole-2-sulfonami... 2 0
Kinesin-like protein KIF11 inhibitor AGN-PC-07R5ZC family 1 5
Androgen receptor ligand AGN-PC-09M5YY family 1 2
Aldose reductase and Aldo-keto reductase family 1 member B10 i... 1 2
Carbonic anhydrase 4 and Carbonic anhydrase 2 inhibitor 5,10-d... 3 1
Proto-oncogene tyrosine-protein kinase Src and cAMP-dependent ... 2 0
Indoles Metabolite 7-Hydroxyheptaphylline Family 4 0
6-bromo-2,3,4,9-tetrahydro-1H-carbazol-1-ol NP 6-bromo-2,3,4,9... 2 0
2-[2-(4-hydroxyphenyl)ethyl]-6-methylpyridin-1-ium-3-ol NP 2-(... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00252161 DNC005990 Investigative Drug 4-(3-(4-hydroxyphenyl)-1H-indol-2-yl)phenol
CFAMM00252147 DNC005989 Investigative Drug 4-(2-phenyl-1H-indol-3-yl)phenol
CFAMM00252146 DNC005988 Investigative Drug 4-(3-phenyl-1H-indol-2-yl)phenol
CFAMM00252150 DNC013193 Investigative Drug 2-(4-benzyl-piperidin-1-ylmethyl)-1H-indol-6-ol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27513 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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