CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1850
Family Name Oestrogen receptor and Estrogen receptor beta Ligand 4-(2-phenyl-1h-benzo[d]imidazol-1-yl)phenol Family
No. of Seeds 2 No. of Other Members 9
Family Centroid CFAMM00252168 Functional Category Investigative Drug
Superfamily Oestrogen receptor and Estrogen receptor beta Binder Superfamily 3
Class Class 931

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Astemizole Family 7 240
Platelet-derived growth factor receptor Ligand CP-868596 Family 3 91
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Tyrosine kinase Inhibitor PKI166 Family 17 198
Glucan synthesis regulatory protein Inhibitor Pyridobenzimidaz... 2 12
Nitric oxide synthase, inducible Inhibitor 4-(1h-imidazol-1-yl... 1 7
D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1... 17 100
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 3 23
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-[3-(4-... 7 128
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 8 8
Fatty-acid amide hydrolase 1 Inhibitor BMS-1 Family 5 22
Indoleamine 2,3-dioxygenase 1 Inhibitor 2-(1h-imidazol-4-yl)be... 2 6
Cytochrome P450 11B1, mitochondrial Inhibitor (3-((1h-imidazol... 2 5
Platelet-derived growth factor receptor alpha and Platelet-der... 3 18
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 10 46
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 13 15
Proto-oncogene tyrosine-protein kinase Src and Cyclin-dependen... 2 1
Tyrosine-protein kinase Lck inhibitor AGN-PC-073GX8 family 12 1
Survival motor neuron protein inhibitor CHEMBL1379159 family 1 10
Cellular tumor antigen p53 and Prelamin-A/C inhibitor CHEMBL14... 2 11
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Neuropeptide Y receptor type 1 ligand 1-[3-[1-(cyclohexylmethy... 15 9
Coagulation factor X and Cationic trypsin inhibitor AGN-PC-075... 26 7
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 3
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 0
Hepatocyte growth factor receptor ligand 4-[(6-phenyl-[1,2,4]t... 3 6
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 1 3
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 4 11
Lysine--tRNA ligase inhibitor 4-[[[2-(2-piperazin-1-ylpyridin-... 2 1
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 11 1
Tyrosine-protein kinase Lck inhibitor 3-[[2-(benzimidazol-1-yl... 2 0
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Phosphatidylinositol 4-kinase beta inhibitor (4E)-2-fluoro-4-[... 1 3
Leukotriene A-4 hydrolase inhibitor AGN-PC-00EW8S family 1 2
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 1
Cannabinoid receptor 2 ligand AGN-PC-03LKW5 family 24 5
C-C chemokine receptor type 5 ligand SureCN13543570 family 2 0
Metabotropic glutamate receptor 2 ligand 2-[[(1R,5S)-6-[(2,5-d... 2 3
Nociceptin receptor and Delta-type opioid receptor ligand 2-[3... 2 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Adenosine receptor A2b and Gamma-aminobutyric acid receptor su... 1 1
Thromboxane A2 receptor ligand SureCN9681521 family 1 0
Arachidonate 5-lipoxygenase-activating protein inhibitor 1-[(2... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00252168 DNC005992 Investigative Drug 4-(2-phenyl-1H-benzo[d]imidazol-1-yl)phenol
CFAMM00252165 DNC012129 Investigative Drug 4-(2-Butyl-benzoimidazol-1-ylmethyl)-phenol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27264 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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