CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1862
Family Name Glycogen synthase kinase-3 beta and Mitogen-activated protein kinase 11 Inhibitor L-779450 Family
No. of Seeds 8 No. of Other Members 8
Family Centroid CFAMM00252470 Functional Category Investigative Drug
Superfamily Indoleamine 2,3-dioxygenase 1 and Glycogen synthase kinase-3 beta Binder Superfamily
Class Class 931

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Astemizole Family 7 240
DNA Binder Elliptinium Acetate Family 11 116
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 13
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
Receptor tyrosine-protein kinase erbB-2 Inhibitor TAK-285 Family 16 124
SB1518 family 7 103
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 11 41
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Tyrosine kinase Inhibitor PKI166 Family 17 198
Glucan synthesis regulatory protein Inhibitor Pyridobenzimidaz... 2 12
Heat shock protein HSP 90-alpha Inhibitor 8-benzo[1,3]dioxol-,... 5 83
Peptide deformylase, mitochondrial Inhibitor 8-(2,3,4-trimetho... 8 15
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 3 23
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 7-et... 7 57
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-[3-(4-... 7 128
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
Adenosine receptor A1 and Adenosine receptor A3 Ligand 2-(4-me... 3 23
Oestrogen receptor and Estrogen receptor beta Ligand 4-(3-phen... 5 14
Oestrogen receptor and Estrogen receptor beta Ligand 4-(2-phen... 2 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 50 17
Acetylcholinesterase and Cholinesterase Inhibitor 6-hydroxy-1,... 4 2
TGF-beta receptor type-1 Ligand SB-431542 Family 2 42
Fatty-acid amide hydrolase 1 Inhibitor BMS-1 Family 5 22
Glycogen synthase kinase-3 beta Inhibitor 6-hydroxymanzamine A... 3 0
Indoleamine 2,3-dioxygenase 1 Inhibitor 2-(1h-imidazol-4-yl)be... 2 6
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3,3'-pyrazine-2,5-... 2 14
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 1 0
Serine/threonine-protein kinase mTOR Inhibitor (4-(6-morpholin... 2 11
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 13 15
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Adenosine receptor A1 and Adenosine receptor A2a ligand NSC658... 8 54
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Serine/threonine-protein kinase B-raf inhibitor SureCN1015955 ... 17 18
Vascular endothelial growth factor receptor 2 and Angiopoietin... 2 11
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-072YMN ... 7 11
Serine/threonine-protein kinase B-raf inhibitor 3-[7-[4-[[(3R)... 6 7
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
Proto-oncogene tyrosine-protein kinase Src and Cyclin-dependen... 2 1
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 7 16
Tyrosine-protein kinase Lck inhibitor AGN-PC-073GX8 family 12 1
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 6 7
Epidermal growth factor receptor and Tyrosine-protein kinase A... 4 3
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 7 5
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Su... 2 16
Serine/threonine-protein kinase Chk2 and Serine/threonine-prot... 3 6
Adenosine receptor A3 and Adenosine receptor A2a ligand 4-(5-b... 2 5
Tyrosine-protein kinase HCK and Proto-oncogene tyrosine-protei... 5 9
Proto-oncogene tyrosine-protein kinase Src and Tyrosine-protei... 12 8
Casein kinase I isoform delta and Mitogen-activated protein ki... 3 18
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
Melatonin receptor type 1A ligand N-[2-(5-methoxy-2-phenyl-1H-... 1 2
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 3 20
D(3) dopamine receptor and D(2) dopamine receptor ligand 2-[4-... 2 3
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Epidermal growth factor receptor ligand Pyrimido[4,5-b]indole ... 1 4
Neuropeptide Y receptor type 5 ligand 3-[2-[6-[2-[(2-methylpro... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 5
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 5 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Proto-oncogene tyrosine-protein kinase Src and Epidermal growt... 9 9
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 17
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 3
Calmodulin-domain protein kinase 1 and Tyrosine-protein kinase... 5 5
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Hepatocyte growth factor receptor ligand 4-[(6-phenyl-[1,2,4]t... 3 6
Renin inhibitor [2-(5-fluoro-2-methylphenoxy)-5-hydroxy-1-phen... 2 0
Acyl-CoA desaturase 1 and Acyl-CoA desaturase inhibitor 2-[4-[... 2 6
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 1 6
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 1 3
Receptor tyrosine-protein kinase erbB-2 ligand N-[3-chloro-4-(... 4 3
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 2
Adenosine kinase inhibitor (2R,3R,4R)-2-[4-(2,3-dihydro-1,4-be... 5 2
Macrophage colony-stimulating factor 1 receptor and Ephrin typ... 1 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-075YQ1 fa... 4 0
Serine/threonine-protein kinase B-raf and RAF proto-oncogene s... 1 0
Estrogen receptor beta and Estrogen receptor ligand SureCN6442... 1 2
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 8 6
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 4 11
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 6
Serine/threonine-protein kinase Chk1 inhibitor SureCN6387344 f... 6 11
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Vascular endothelial growth factor receptor 2 and Vascular end... 4 2
Lysine--tRNA ligase inhibitor 4-[[[2-(2-piperazin-1-ylpyridin-... 2 1
Coagulation factor VII inhibitor [3-[(5E)-5-(5-carbamimidoyl-1... 3 2
Serine/threonine-protein kinase Chk1 inhibitor 6-chloro-3-(1,3... 4 2
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 11 1
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 1 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 4 2
Tyrosine-protein kinase Lck inhibitor 3-[[2-(benzimidazol-1-yl... 2 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Neuropeptide Y receptor type 5 ligand 6-ethylsulfonyl-2-(4-phe... 4 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 5
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 5 2
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
Phosphatidylinositol 4-kinase beta inhibitor (4E)-2-fluoro-4-[... 1 3
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Transient receptor potential cation channel subfamily V member... 1 0
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 6 2
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 4-[4-... 1 0
Leukotriene A-4 hydrolase inhibitor AGN-PC-00EW8S family 1 2
Vascular endothelial growth factor receptor 2 and Vascular end... 1 1
Purine nucleoside phosphorylase inhibitor SureCN6345422 family 9 11
Type-1 angiotensin II receptor ligand SureCN7941428 family 2 2
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 16 0
Glucagon receptor ligand SureCN2647807 family 3 7
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 2
Adenosine receptor A1 and Adenosine receptor A2a ligand 7-meth... 2 0
Cyclin-dependent kinase 1 inhibitor AGN-PC-075VQQ family 2 0
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 2 0
G2/mitotic-specific cyclin-B2 and Cyclin-dependent kinase 1 in... 2 1
Rho-associated protein kinase 2 inhibitor SureCN1519463 family 5 1
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 8
Nociceptin receptor and Delta-type opioid receptor ligand 2-[3... 2 1
Epidermal growth factor receptor ligand Pyrido[3,4-d]pyrimidin... 3 1
D(2) dopamine receptor ligand AGN-PC-07C1V6 family 2 3
Glucocorticoid receptor ligand SureCN12238714 family 16 4
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-07CR... 4 0
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-04WWHE family 2 0
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-04WVYY family 1 0
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 7 4
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 1 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 1
Serine/threonine-protein kinase Chk2 inhibitor (6E)-4-fluoro-6... 3 6
Serine/threonine-protein kinase mTOR inhibitor 3-(cyclohexylme... 2 1
Lysosomal Pro-X carboxypeptidase inhibitor 4-[6-[(2S)-2-(5,6-d... 2 2
Angiopoietin-1 receptor ligand 4-[4-(6-methoxynaphthalen-2-yl)... 6 4
Calcitonin gene-related peptide type 1 receptor ligand N-[5-(4... 3 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 5 3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00252469 CHEMBL200320 Bioactive SB-476429-A
CFAMM00252467 CHEMBL381250 Bioactive AGN-PC-075YW8
CFAMM00252475 CHEMBL200889 Bioactive AGN-PC-03LN4H
CFAMM00252465 CHEMBL381447 Bioactive AGN-PC-034IMT
CFAMM00252482 CHEMBL200172 Bioactive AGN-PC-075YXZ
CFAMM00252471 CHEMBL200258 Bioactive AGN-PC-075YYX
CFAMM00252470 DNC006033 Investigative Drug L-779450

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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