CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1870
Family Name Delta-type opioid receptor and Kappa-type opioid receptor Ligand N-benzyl-17-(cyclopropylmethyl)morphinan-3-amine Family
No. of Seeds 8 No. of Other Members 32
Family Centroid CFAMM00252903 Functional Category Investigative Drug
Superfamily Kappa-type opioid receptor and Delta-type opioid receptor Binder Superfamily 3
Class Class 2121

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
5-hydroxytryptamine 2 receptor Ligand tricyclic antidepressant... 29 680
Noradrenergic re-uptake inhibitor Dibenzazepine Imipramine Family 8 178
Histamine H1 receptor ligand piperazine derivative Cyclizine F... 16 140
Squalene monooxygenase Inhibitor Naftifine Family 8 32
Calmodulin Inhibitor Aprindine Family 1 4
D(2) dopamine receptor Ligand Nomifensine Family 6 100
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
Sigma non-opioid intracellular receptor 1 Ligand Dimemorfan Fa... 5 15
Potassium voltage-gated channel subfamily A member 3 Ligand CP... 4 26
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Progesterone receptor Ligand 2,2,4-trimethyl-6-phenyl-1,2-dihy... 5 82
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 67
Alpha-2A adrenergic receptor Ligand 7-nitro-1,2,3,4-tetrahydro... 6 31
Adenosine receptor A3 and Glutamate receptor ionotropic, NMDA ... 4 30
Androgen receptor Ligand YM-175735 Family 30 129
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 7 13
Dipeptidyl peptidase 4 Inhibitor (3s,4r)-3-butyl-1-phenylpiper... 2 40
Histamine H3 receptor Ligand (r)-1-(4-nitrophenethyl)-2-methyl... 16 38
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 47
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 42
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 18
Sigma non-opioid intracellular receptor 1 ligand CHEMBL101300 ... 2 1
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 4
D(4) dopamine receptor and Alpha-1B adrenergic receptor ligand... 7 27
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
5-hydroxytryptamine receptor 7 and Sodium-dependent serotonin ... 5 1
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 0
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 2 5
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 7 ligand 5-methyl-6-(6-methyl-5,6... 2 0
Sigma non-opioid intracellular receptor 1 ligand 1-[4-[1-adama... 4 23
Testosterone 17-beta-dehydrogenase 3 inhibitor SureCN4802053 f... 2 2
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 4
Substance-P receptor ligand (2R,3R)-2-benzhydryl-N-(2-iodophen... 2 0
Androgen receptor ligand 4-[(1R,5R)-3-hydroxy-3-methyl-8-azabi... 8 7
Acetylcholinesterase and Butyrylcholinesterase inhibitor AGN-P... 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 4
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 1 3
Lysosomal Pro-X carboxypeptidase and Glutamate receptor ionotr... 1 0
Cholinesterase inhibitor 10-[[(1R,9aR)-2,3,4,6,7,8,9,9a-octahy... 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 3 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00252903 DNC010080 Investigative Drug N-Benzyl-17-(cyclopropylmethyl)morphinan-3-amine
CFAMM00252902 DNC010081 Investigative Drug 17-(Cyclopropylmethyl)-N-phenylmorphinan-3-amine
CFAMM00252868 DNC007684 Investigative Drug MCL-149
CFAMM00252891 DNC006049 Investigative Drug MCL-182
CFAMM00252905 DNC010082 Investigative Drug N-Benzyl-17-(cyclobutylmethyl)morphinan-3-amine
CFAMM00252904 DNC010083 Investigative Drug 17-(Cyclobutylmethyl)-N-phenylmorphinan-3-amine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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