CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1877
Family Name 3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-steroid 4-dehydrogenase 2 Inhibitor (3-methyl-4-(4-phenoxybenzoyl)phenyl)acetic Acid Family
No. of Seeds 2 No. of Other Members 56
Family Centroid CFAMM00253061 Functional Category Investigative Drug with Human Metabolite & Natural Product
Superfamily 3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-steroid 4-dehydrogenase 2 Binder Superfamily
Class Class 197

Cousin Family NamesSeedsMembers
Thyroid hormone receptor alpha ligand thyroid hormone analog L... 10 61
Retinoic acid receptor Ligand naphthoic acid derivative Adapal... 2 264
Prostaglandin G/H synthase 2 Inhibitor Diflunisal Family 7 421
Histamine H1 receptor Ligand Doxepin Family 8 89
Peroxisome proliferator-activated receptor alpha Ligand Fenofi... 3 127
Sodium channel protein type 5 subunit alpha Ligand Dyclonine F... 6 174
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Cyclooxygenase Inhibitor Fenoprofen Family 4 1077
Cyclooxygenase inhibitor salicylate derivative Aspirin family 3 234
Prostaglandin G/H synthase 2 Inhibitor Nabumetone Family 4 267
Signal transducer and activator of transcription 3 Inhibitor A... 5 249
Solute carrier family 12 member 1 Inhibitor Ethacrynic Acid Fa... 3 42
Vitamin K epoxide reductase complex subunit 1 Inhibitor Warfar... 9 508
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor Mycophenola... 4 353
Heat shock protein 90, putative Inhibitor Cromoglicate Family 14 2827
DNA Binder Methoxsalen Family 10 1638
Vitamin K-dependent gamma-carboxylase Inhibitor Anisindione Fa... 3 243
D-alanyl-D-alanine carboxypeptidase Inhibitor B-lactams Family 59 1364
Aldehyde oxidase Inhibitor Isovanillin Family 6 429
Ipriflavone family 62 2480
Rotenone family 16 107
Danthron family 11 141
Agrimophol family 10 22
Leukotriene B4 receptor 1 Ligand LY293111 Family 24 79
Sphingosine kinase 2 Inhibitor Phenoxodiol Family 24 682
Steryl-sulfatase Inhibitor Stx 64 Family 7 160
Muscarinic acetylcholine receptor M1 Ligand GSK1034702 Family 7 148
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 9 123
Free fatty acid receptor 1 Ligand TAK-875 Family 2 54
Interleukin-1 beta Inhibitor Diacerein Family 3 77
Integrase Inhibitor L-708,906 Family 1 8
Glucose-6-phosphate translocase Inhibitor Mumbaistatin Family 3 11
Endothelin-1 receptor Ligand PD156707 Family 41 211
Estrogen receptor beta Ligand 2-(4-hydroxy-phenyl)benzofuran-5... 5 82
Phospholipase A2 Inhibitor P-anisic Acid Family 2 178
Peroxisome proliferator-activated receptor gamma Ligand (2s)-2... 10 126
Cytosolic phospholipase A2 Inhibitor 1,1,1-trifluoro-6-(4-hexy... 9 86
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 Ligand... 4 26
Steryl-sulfatase Inhibitor Sulfamic Acid 4-(3-methoxy-benzoyl)... 5 24
Steryl-sulfatase Inhibitor 3-{4-[(aminosulfonyl)oxy]benzoyl}ph... 5 3
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 2,5-... 2 96
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor (2,5... 1 9
Steryl-sulfatase Inhibitor Sulfamic Acid 2-nonyl-4-oxo-4h-chro... 4 68
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 8 66
Aromatase and DNA-dependent protein kinase catalytic subunit I... 6 19
Oestrogen receptor and Estrogen receptor beta Ligand 7-chloro-... 2 27
Phospholipase A2 Inhibitor 3,9-dihydroxy-2,10-diprenylpterocap... 9 25
Interstitial collagenase Inhibitor N-hydroxy-4-(4-methoxy-phen... 6 4
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 9 81
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 3
4-aminobutyrate aminotransferase, mitochondrial and Succinate-... 4 22
Oestrogen receptor and Estrogen receptor beta Ligand 3,8-dihyd... 20 57
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Ellagi... 1 11
Thyroid hormone receptor beta Ligand 2-hexylphenyl Acrylate Fa... 4 83
Cytosolic phospholipase A2 Inhibitor [6,3''']biflavone Family 5 5
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 4 37
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3-(6-hydroxy-2-nap... 7 9
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 2 12
MO15-related protein kinase Pfmrk Inhibitor WR-289012 Family 2 17
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 3-ben... 4 74
Cannabinoid receptor 2 Ligand 2-(2-methoxybenzyl)-3h-benzo[f]c... 6 32
Arachidonate 12-lipoxygenase, 12S-type and Arachidonate 15-lip... 3 7
Protein kinase C gamma type and Protein kinase C alpha type In... 2 1
Indoleamine 2,3-dioxygenase 1 Inhibitor 2-hydroxygarvin A Family 2 2
Cytochrome P450 3A4 Inhibitor (-)-cubebininolide Family 4 28
Interleukin-8 Inhibitor 2-(2-(2-fluorophenoxy)phenyl)acetic Ac... 2 4
Amine oxidase [flavin-containing] B Inhibitor (s)(+)-7-fluoro-... 11 11
NAD(P)H dehydrogenase [quinone] 1 Inhibitor 4-hydroxy-3-(2-nap... 12 1
Amine oxidase [flavin-containing] B Inhibitor 3-(4-methoxyphen... 3 29
Aromatase Inhibitor 3,4-bis(3,4-dimethoxyphenyl)furan-2(5h)-on... 4 86
Amine oxidase [flavin-containing] B Inhibitor 4-oxo-4h-chromen... 2 3
Amine oxidase [flavin-containing] B Inhibitor 8-bromo-6-methyl... 5 44
Tyrosine-protein phosphatase non-receptor type 1 Ligand Formyl... 1 1
Cytochrome P450 3A4 Inhibitor Diethoxyflourescein Family 3 9
Arachidonate 5-lipoxygenase Inhibitor 4,5-dimethoxy-10h-anthra... 1 4
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 2-(3-c... 5 72
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 2-(3-b... 6 21
Epidermal growth factor receptor Ligand 3-(3-chloro-phenyl)-5,... 10 64
Protein farnesyltransferase subunit beta Inhibitor Cylindrol A... 3 43
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 3 0
Prostaglandin G/H synthase 2 Inhibitor 3,4-dibenzyloxy-2'-hydr... 7 40
Fatty-acid amide hydrolase 1 Inhibitor Benzofuran-2-ylboronic ... 1 14
Androgen receptor Ligand Palodesangren E Family 12 43
CGMP-dependent protein kinase Inhibitor Tenellone A Family 1 7
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
Creatine kinase Inhibitor 5-(4'-benzoylbiphenyl-4-yl)-2-furoic... 2 66
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 6 6
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 6 19
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 10 8
Retinoic acid receptor RXR-alpha and Peroxisome proliferator-a... 3 17
Survival motor neuron protein and Retinal dehydrogenase 1 inhi... 1 11
Acetylcholinesterase inhibitor AGN-PC-003A5N family 3 9
Amine oxidase [flavin-containing] B inhibitor 5-(4,4,4-trifluo... 2 9
Arachidonate 5-lipoxygenase inhibitor 7-[[3-fluoro-5-(3-hydrox... 2 10
Free fatty acid receptor 1 ligand 3-[4-[[3-[2,6-dimethyl-4-[3-... 1 0
Free fatty acid receptor 1 ligand 3-[4-[[3-[4-(1,1-dioxothian-... 3 0
Arachidonate 5-lipoxygenase inhibitor methyl (2S)-2-[3-fluoro-... 2 0
Peroxisome proliferator-activated receptor delta ligand SureCN... 1 0
Protein kinase C alpha type inhibitor [2-(hydroxymethyl)-5-oxo... 2 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 14
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 7 13
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 7
Androgen receptor and Estrogen receptor ligand estradiol benzo... 1 29
Protein kinase C beta type and Protein kinase C eta type inhib... 1 0
3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (4R)... 1 4
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 2
Estrogen receptor beta and Estrogen receptor ligand 7-bromo-3-... 1 0
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 7
Thromboxane A2 receptor ligand AGN-PC-003UTI family 1 0
Arachidonate 5-lipoxygenase and Prostaglandin G/H synthase 1 i... 1 12
Sterol 26-hydroxylase, mitochondrial and 1,25-dihydroxyvitamin... 1 2
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 2 7
Sodium-dependent serotonin transporter and Sodium-dependent do... 3 78
Free fatty acid receptor 1 ligand 3-[4-[2-[2-(cyanomethoxy)phe... 1 2
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 1 1
Acetylcholinesterase inhibitor SureCN10041451 family 1 1
Thioredoxin glutathione reductase and Beta-lactamase inhibitor... 1 0
M-phase inducer phosphatase 2 and Dual specificity protein pho... 1 0
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 18
Steryl-sulfatase inhibitor [(8R,9S,13S,14S)-13-methyl-17-oxo-7... 1 9
Reverse transcriptase/RNaseH inhibitor AC1O5CPP family 1 5
Transient receptor potential M8 protein ligand 2-[1-diethoxyph... 1 0
Glutamate carboxypeptidase 2 inhibitor 2-phenylmethoxy-6-(2-su... 2 3
Vasopressin V2 receptor and C-C chemokine receptor type 4 liga... 1 1
Multidrug resistance protein 1 inhibitor 1-[4-[(2R)-2-hydroxy-... 1 0
Indoleamine 2,3-dioxygenase 1 inhibitor AGN-PC-04S2CP family 1 3
Arachidonate 5-lipoxygenase inhibitor AGN-PC-00OPWJ family 1 1
Corticosteroid 11-beta-dehydrogenase isozyme 2 and Corticoster... 1 2
Cannabinoid receptor 1 and Cytochrome P450 3A4 ligand LY320135... 1 0
Prelamin-A/C and Inositol monophosphatase 1 inhibitor MLS00053... 1 1
Benzoic Acid and Derivatives Metabolite Methyl 3-(2,3-dihydrox... 1 3
Acenes Metabolite Lacinilene C Family 2 3
Acenes Metabolite 3-Hydroxy-9-(4-hydroxyphenyl)-1H,3H-naphtho[... 1 0
Benzopyrans Metabolite Pergillin Family 1 1
Benzofurans Metabolite (R)-Bitalin A Family 1 9
Acenes Metabolite Musanolone D Family 2 1
Naphthofurans Metabolite Pyrocurzerenone Family 1 9
Putative NP ZINC31165975 Family 4 0
Putative NP ZINC31158464 Family 3 5
NP 6-(4-ethoxyphenyl)-1,3-dimethyl-4-oxo-4h-cyclohepta[c]furan... 13 3
NP Ethyl 5-(tert-butyl)-3-oxo-8,9,10,11-tetrahydro-3h-benzofur... 1 0
NP 4-(((3-(4-chlorophenyl)-2-methyl-4-oxo-4h-chromen-7-yl)oxy)... 14 0
NP 4-(5-fluoro-3-methylbenzofuran-2-yl)-7,8-dihydrocyclopenta[... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00253061 DNC006082 Investigative Drug (3-methyl-4-(4-phenoxybenzoyl)phenyl)acetic acid
CFAMM00253043 DNC014103 Investigative Drug (3,4-dimethylphenyl)(4-phenoxyphenyl)methanone

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26823 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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