CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1882
Family Name Androgen receptor Ligand YM-175735 Family
No. of Seeds 30 No. of Other Members 129
Family Centroid CFAMM00253220 Functional Category Investigative Drug
Superfamily dopamine receptor ligand diphenylbutylpiperidine derivative Pimozide Fluspirilene Superfamily
Class Class 220

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Sodium channel Ligand iminostilbene derivative (tricyclic stru... 2 46
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 10 157
Alpha adrenergic receptor Ligand Droperidol Family 20 244
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 43 161
D(2) dopamine receptor Ligand Nomifensine Family 6 100
Motilin receptor Ligand GSK962040 Family 30 457
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
NMDA receptor Ligand Aptiganel Hcl Family 2 82
Urokinase-type plasminogen activator Inhibitor N-(1-adamantyl)... 2 15
Bifunctional epoxide hydrolase 2 Inhibitor 1-cyclohexyl-3-phen... 5 65
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Glutamate receptor ionotropic, NMDA 2A and Glutamate receptor ... 14 78
Progesterone receptor Ligand 2,2,4-trimethyl-6-phenyl-1,2-dihy... 5 82
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 67
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-chloro-phenyl)... 5 50
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-[2-(... 5 72
Cholecystokinin receptor type A Ligand L-708474 Family 14 82
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 8 32
Androgen receptor Ligand 6-n-propyl -4-trifluoromethylquinolin... 29 13
Cannabinoid receptor 1 Ligand 1-(bis(4-chlorophenyl)methyl)-3-... 4 44
Cannabinoid receptor 1 Ligand 1-[bis(4-iodophenyl)methyl]-3-(4... 4 13
Kinesin-like protein KIF11 Inhibitor N-{4'-[(trifluoromethyl)s... 3 1
Kinesin-like protein KIF11 Inhibitor N-[4'-(trifluoromethyl)-4... 7 134
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 7 13
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 47
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
Induced myeloid leukemia cell differentiation protein Mcl-1 an... 2 7
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 18
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 12 4
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 4 24
Tyrosinase Inhibitor 1-hydroxy-3-(4-(trifluoromethyl)phenyl)ur... 2 3
Trypsin Inhibitor 1,3-di-p-tolyl-[1,3]diazetidine-2,4-dione Fa... 2 16
DNA topoisomerase Inhibitor 6-p-tolylamino-1h-pyrimidine-2,4-d... 3 17
DNA topoisomerase Inhibitor 6-(naphthalen-2-ylamino)-1h-pyrimi... 2 1
Substance-P receptor ligand (2S)-2-N-[(2S)-1-[benzyl(methyl)am... 6 3
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 5 5
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-(3-... 6 12
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 3 1
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 5 14
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 4 6
C-C chemokine receptor type 3 ligand 4-[(3-acetylphenyl)carbam... 3 4
Melanin-concentrating hormone receptor 1 ligand 1-[(6S)-6-(3-c... 7 18
Melanin-concentrating hormone receptor 1 ligand 3-(3-chloro-4-... 8 24
Melanin-concentrating hormone receptor 1 ligand 3-(3-chloro-4-... 13 6
Melanin-concentrating hormone receptor 1 ligand 1-[(6S)-6-(3-c... 2 3
Melanin-concentrating hormone receptor 1 ligand 3-(3-bromophen... 4 0
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 11 8
C-C chemokine receptor type 3 ligand SureCN6703027 family 2 1
D(3) dopamine receptor and D(2) dopamine receptor ligand 3-[4-... 4 23
Melanin-concentrating hormone receptor 1 ligand 1-[[4-[4-(3-cy... 14 23
Melanin-concentrating hormone receptor 1 ligand 1-[2-[4-(3-cya... 3 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 6
Bifunctional epoxide hydrolase 2 inhibitor 1-(2,3,4-trifluorop... 2 2
Bifunctional epoxide hydrolase 2 inhibitor 1-(2-adamantyl)-3-(... 2 4
D(4) dopamine receptor ligand 1-Piperidineacetamide, 4-(2-cyan... 3 7
Melanin-concentrating hormone receptor 1 ligand SureCN3845324 ... 7 4
Melanin-concentrating hormone receptor 1 ligand 1-[4-(3-cyanop... 4 9
Melanin-concentrating hormone receptor 1 ligand SureCN14265737... 2 0
Melanin-concentrating hormone receptor 1 ligand N-[2-[4-(3-cya... 3 9
D(3) dopamine receptor and D(2) dopamine receptor ligand RGH-1... 8 0
Melanin-concentrating hormone receptor 1 ligand SureCN14265866... 11 2
C-C chemokine receptor type 3 ligand 4-(5-amino-2-oxo-3H-benzi... 1 0
Melanin-concentrating hormone receptor 1 ligand 3-(3-chloro-4-... 2 1
Melanin-concentrating hormone receptor 1 ligand SureCN14101999... 3 0
Nociceptin receptor ligand 2-[3-[1-[(1R)-1,2-dihydroacenaphthy... 2 0
Melanin-concentrating hormone receptor 1 ligand SureCN13655018... 6 23
Melanin-concentrating hormone receptor 1 ligand AGN-PC-0762XZ ... 3 1
Melanin-concentrating hormone receptor 1 ligand methyl 4-[(1S,... 1 0
Melanin-concentrating hormone receptor 1 ligand AGN-PC-00CYMY ... 1 0
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor 1-(3,5... 2 0
Histamine H3 receptor and Histamine receptor H3 ligand 1-cyclo... 3 4
Progesterone receptor ligand 3-(3-cyclobutyl-2-sulfanylidene-1... 2 3
C-X-C chemokine receptor type 3 and Muscarinic acetylcholine r... 1 0
Substance-P receptor ligand N-[[3,5-bis(trifluoromethyl)phenyl... 1 0
C-C chemokine receptor type 3 ligand AGN-PC-073RIP family 2 4
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 11 4
Melanin-concentrating hormone receptor 1 ligand SureCN13451707... 3 1
Melanin-concentrating hormone receptor 1 ligand 1-[4-chloro-3-... 1 1
C-C chemokine receptor type 5 ligand AC1L9YPM family 3 6
Sodium-dependent noradrenaline transporter inhibitor SureCN408... 5 12
Transient receptor potential cation channel subfamily V member... 1 1
Neuropeptide Y receptor type 5 ligand AGN-PC-01NRYI family 2 0
Phospholipase D1 and Phospholipase D2 inhibitor N-[(2S)-1-[4-(... 3 5
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand SureC... 3 5
Melanin-concentrating hormone receptor 1 and Alpha-1A adrenerg... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-[2-... 3 1
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 0
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-(3-... 4 3
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-(3-... 1 0
DNA polymerase III PolC-type inhibitor HB-EMAU family 17 7
DNA polymerase III PolC-type inhibitor SureCN3473660 family 2 0
DNA polymerase III PolC-type inhibitor SureCN3471150 family 1 0
Sterol O-acyltransferase 1 inhibitor SureCN7565101 family 2 10
Mu-type opioid receptor ligand 1-[[(3S)-2-[[(2R)-1-[(4-cyanoph... 1 0
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN9352718 f... 2 3
Reverse transcriptase/RNaseH inhibitor (4S)-6-fluoro-4-(3-meth... 7 1
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN13328411 ... 4 2
Acyl-CoA:cholesterol acyltransferase inhibitor 1-[2,6-di(propa... 7 2
Acyl-CoA:cholesterol acyltransferase inhibitor 1-[2,6-di(propa... 2 0
Extracellular calcium-sensing receptor ligand 478963-46-1 family 2 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00253281 CHEMBL382668 Bioactive SureCN14265854
CFAMM00253320 CHEMBL187996 Bioactive AGN-PC-005HWS
CFAMM00253333 CHEMBL1254326 Bioactive 1-[(6S)-6-(3-cyanophenyl)-3-bicyclo[4.1.0]heptanyl]-1-[2-[di(propan-2-yl)amino]ethyl]-3-(3-fluorophenyl)urea
CFAMM00253287 CHEMBL1254479 Bioactive 1-[(6S)-6-(3-cyanophenyl)-3-bicyclo[4.1.0]heptanyl]-3-(3,4-difluorophenyl)-1-[2-[di(propan-2-yl)amino]ethyl]urea
CFAMM00253360 CHEMBL382140 Bioactive SureCN14102202
CFAMM00253239 CHEMBL190401 Bioactive SureCN3839114
CFAMM00253306 CHEMBL229769 Bioactive 1-[(3R,6S)-6-(3-cyanophenyl)-3-bicyclo[4.1.0]heptanyl]-3-(3,4-difluorophenyl)-1-[2-[di(propan-2-yl)amino]ethyl]urea
CFAMM00253346 CHEMBL205285 Bioactive SureCN14102066
CFAMM00253231 CHEMBL2096696 Bioactive 1-(3-cyanophenyl)-3-[(1R,2S)-2-[[(3R)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]cyclohexyl]urea
CFAMM00253244 CHEMBL206831 Bioactive 1-[(1S,4R,5S)-1-(4-cyanophenyl)-4-bicyclo[3.1.0]hexanyl]-3-[4-fluoro-3-(trifluoromethyl)phenyl]-1-(3-piperazin-1-ylpropyl)urea
CFAMM00253358 CHEMBL190780 Bioactive AGN-PC-00FFWK
CFAMM00253311 CHEMBL426369 Bioactive SureCN14266150
CFAMM00253224 CHEMBL191409 Bioactive AGN-PC-007V0I
CFAMM00253330 CHEMBL206616 Bioactive 1-[(1S,4R,5S)-1-(3-fluorophenyl)-4-bicyclo[3.1.0]hexanyl]-3-[4-fluoro-3-(trifluoromethyl)phenyl]-1-[3-(4-methylpiperazin-1-yl)propyl]urea
CFAMM00253236 CHEMBL1254399 Bioactive 1-[(6S)-6-(3-cyanophenyl)-3-bicyclo[4.1.0]heptanyl]-3-(3,5-difluorophenyl)-1-[2-[di(propan-2-yl)amino]ethyl]urea
CFAMM00253337 CHEMBL363044 Bioactive 1-[4-(3-cyanophenyl)phenyl]-1-(1-cyclopentylpiperidin-4-yl)-3-[4-fluoro-3-(trifluoromethyl)phenyl]urea
CFAMM00253262 CHEMBL378019 Bioactive SureCN14102140
CFAMM00253303 CHEMBL205838 Bioactive 1-[(1S,4R,5S)-1-(4-cyano-3-fluorophenyl)-4-bicyclo[3.1.0]hexanyl]-3-[4-fluoro-3-(trifluoromethyl)phenyl]-1-[3-(4-methylpiperazin-1-yl)propyl]urea
CFAMM00253203 CHEMBL2096764 Bioactive 1-(3-cyanophenyl)-3-[(1R,2S)-2-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]cyclohexyl]urea
CFAMM00253216 CHEMBL380509 Bioactive 1-[(1S,4R,5S)-1-(4-fluorophenyl)-4-bicyclo[3.1.0]hexanyl]-3-[4-fluoro-3-(trifluoromethyl)phenyl]-1-[3-(4-methylpiperazin-1-yl)propyl]urea
CFAMM00253209 CHEMBL1818409 Bioactive 1-[2-fluoro-3-(trifluoromethyl)phenyl]-3-(4-phenylbutan-2-yl)urea
CFAMM00253283 CHEMBL554073 Bioactive 2-fluoro-5-[2-oxo-3-[2-[4-(trifluoromethyl)piperidin-1-yl]ethyl]imidazolidin-1-yl]benzonitrile
CFAMM00253235 CHEMBL1254398 Bioactive SureCN14266124
CFAMM00253309 CHEMBL229768 Bioactive 3-(3-cyanophenyl)-1-[(3R,6S)-6-(3-cyanophenyl)-3-bicyclo[4.1.0]heptanyl]-1-[2-[di(propan-2-yl)amino]ethyl]urea
CFAMM00253315 CHEMBL1289614 Bioactive SureCN136046
CFAMM00253328 CHEMBL387962 Bioactive SureCN14266131
CFAMM00253321 CHEMBL191079 Bioactive AGN-PC-00FG3A
CFAMM00253227 CHEMBL190842 Bioactive SureCN14101930
CFAMM00253314 CHEMBL204407 Bioactive 1-[(1S,4R,5S)-1-(3-cyano-4-fluorophenyl)-4-bicyclo[3.1.0]hexanyl]-3-[4-fluoro-3-(trifluoromethyl)phenyl]-1-[3-(4-methylpiperazin-1-yl)propyl]urea
CFAMM00253220 DNC006097 Investigative Drug YM-175735

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24631 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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