CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1883
Family Name Cannabinoid receptor 1 Ligand 1,3,5-triphenylimidazolidine-2,4-dione Family
No. of Seeds 2 No. of Other Members 17
Family Centroid CFAMM00253365 Functional Category Investigative Drug with Natural Product
Superfamily Cannabinoid receptor 1 Ligand 1,3,5-triphenylimidazolidine-2,4-dione Superfamily
Class Class 1613

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 10 157
Alpha adrenergic receptor Ligand Droperidol Family 20 244
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 43 161
Motilin receptor Ligand GSK962040 Family 30 457
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Integrin alpha-4 Inhibitor BIO-1211 Family 16 83
Vasopressin-neurophysin 2-copeptin Inhibitor Niravoline Family 7 45
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
Voltage-dependent T-type calcium channel subunit alpha-1I Liga... 9 19
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 19 88
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Aromatase Inhibitor 3-(4-amino-phenyl)-1-methyl-pyrrolidine-2,... 4 8
Cholecystokinin receptor type A Ligand L-708474 Family 14 82
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... 4 21
Phospholipase D1 Inhibitor Halopemide Family 17 111
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 1 1
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
Induced myeloid leukemia cell differentiation protein Mcl-1 an... 2 7
Cholecystokinin receptor type A Ligand VL-0494 Family 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
Prothrombin and Plasminogen inhibitor [(1R)-5-amino-1-[[2-[N-(... 1 0
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
Substance-P receptor ligand (2S)-2-N-[(2S)-1-[benzyl(methyl)am... 6 3
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 5 2
B2 bradykinin receptor ligand AGN-PC-074WA4 family 2 3
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 5 14
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 4 6
Disintegrin and metalloproteinase domain-containing protein 17... 1 2
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 15 12
Thyroid hormone receptor beta and DNA-(apurinic or apyrimidini... 1 0
Sigma non-opioid intracellular receptor 1 ligand 2-(2-nitrophe... 2 5
Hypoxia-inducible factor 1-alpha and Ubiquitin carboxyl-termin... 1 1
Calcitonin gene-related peptide type 1 receptor and Dual speci... 8 4
Kappa-type opioid receptor ligand N-methyl-N-[(1S)-2-pyrrolidi... 3 17
5-hydroxytryptamine receptor 1A ligand SureCN4244417 family 10 1
Oxytocin receptor ligand (2R)-2-[(2R,5R)-5-(2,3-dihydro-1H-ind... 2 0
C-C chemokine receptor type 1 ligand SureCN3159355 family 7 9
Calcitonin gene-related peptide type 1 receptor and Cytochrome... 2 17
Nociceptin receptor and Mu-type opioid receptor ligand N,N-dim... 5 4
Nociceptin receptor ligand 2-[3-[1-[(1R)-1,2-dihydroacenaphthy... 2 0
Melanin-concentrating hormone receptor 1 ligand 3-chloro-5-[4-... 2 0
Translocator protein inhibitor CHEMBL2332254 family 6 1
Cannabinoid receptor 2 ligand 1-adamantyl-(5-fluoro-2,3-dihydr... 4 7
Transient receptor potential M8 protein ligand 2-(4-bromopheny... 1 0
Melanocortin receptor 4 ligand N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-c... 26 13
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 6
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 1
Nociceptin receptor and Delta-type opioid receptor ligand spir... 25 9
Melanin-concentrating hormone receptor 1 ligand SureCN5517533 ... 2 3
5-hydroxytryptamine receptor 7 ligand 3-ethyl-3-[4-[4-(4-fluor... 3 1
Mu-type opioid receptor and Nociceptin receptor ligand SureCN8... 7 1
5-hydroxytryptamine receptor 7 ligand 2-[4-[4-(2-oxo-1,3,4,5-t... 1 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 7 12
Substance-P receptor ligand N-[[3,5-bis(trifluoromethyl)phenyl... 1 0
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 3 2
Growth hormone secretagogue receptor type 1 ligand SureCN77944... 1 2
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 11 4
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 4 1
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 5
Vascular endothelial growth factor receptor 2 ligand isoindoli... 1 0
Nociceptin receptor and Mu-type opioid receptor ligand spiropi... 1 0
C-C chemokine receptor type 1 ligand (2R)-2-N-[(4-chlorophenyl... 1 1
Transient receptor potential cation channel subfamily V member... 1 1
Phospholipase D1 and Phospholipase D2 inhibitor N-[(2S)-1-[4-(... 3 5
Potassium voltage-gated channel subfamily H member 2 and D(3) ... 3 0
C-C chemokine receptor type 5 ligand AC1MHPA7 family 2 2
Kappa-type opioid receptor ligand 2-[2-[bis(methylsulfonyl)ami... 2 0
Kappa-type opioid receptor and Delta-type opioid receptor liga... 3 1
Integrin alpha-L inhibitor SureCN6314317 family 2 1
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 0
Sodium- and chloride-dependent glycine transporter 1 inhibitor... 7 1
Aldose reductase inhibitor Spiro-cimqat family 6 8
C5a anaphylatoxin chemotactic receptor 1 ligand SureCN12047568... 1 1
Aldose reductase inhibitor (4R)-6-fluoro-3-methylspiro[1H-quin... 4 16
Aldose reductase inhibitor SureCN10775957 family 2 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00253365 DNC006098 Investigative Drug 1,3,5-triphenylimidazolidine-2,4-dione
CFAMM00253373 DNC006100 Investigative Drug 1,3,5-tris(4-chlorophenyl)imidazolidine-2,4-dione

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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